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Field: Clinical Biochemistry

Limitations and requirements for quality control of sputum smear microscopy for acid-fast bacilli.

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Armand Van Deun, F. Portaels

Journal: PubMedYear: 1998
Citations: 52

Sputum microscopy for acid-fast bacilli (AFB) is considered to be the most appropriate method for case-finding in a tuberculosis (TB) control programme. It is usually carried out by general technicians, often after minimal training. Quality control of their results therefore seems indispensable. The...

Life SciencesBiochemistry, Genetics and Molecular BiologyClinical Biochemistry
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In vitro and in vivo inhibition of maillard reaction products using amino acids, modified proteins, vitamins, and genistein: A review

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Md. Anisur Rahman Mazumder, Parichat Hongsprabhas, Ranganathan Thottiam Vasudevan

Journal: Journal of Food BiochemistryYear: 2019Citations: 48

Maillard reaction is known to result in loss of nutrients, particularly that of essential amino acids; decrease in digestibility and safety issues due to the development of toxic compounds. Maillard reaction products are also known to cause oxidation of tissues and inflammation, thus increasing the ...

Life SciencesBiochemistry, Genetics and Molecular BiologyClinical Biochemistry
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Ginsenoside derivatives inhibit advanced glycation end-product formation and glucose–fructose mediated protein glycation in vitro via a specific structure–activity relationship

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Md Yousof Ali, Susoma Jannat, Mizanur Rahman

Journal: Bioorganic ChemistryYear: 2021Citations: 43

Ginseng (Panax ginseng and red ginseng) extract has been reported to inhibit the formation of advanced glycation end-products (AGEs); however, the potential inhibitory activity of its major constituents (ginsenosides) against AGE formation is still unknown. In the present study, we investigated the ...

Life SciencesBiochemistry, Genetics and Molecular BiologyClinical Biochemistry
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DNA damage and plasma antioxidant indices in Bangladeshi type 2 diabetic patients

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M. Arif, Md. Reazul Islam, T.M. Zaved Waise, F M Nazmul Hassan et al.

Journal: Diabetes & MetabolismYear: 2009Citations: 42

Background and aim Diabetes mellitus is a complex metabolic disorder characterized by a disturbance in glucose metabolism. Recent evidence suggests that increased oxidative stress as well as alteration of antioxidant capacity may be related to the complications seen in patients with type 2 diabetes....

Life SciencesBiochemistry, Genetics and Molecular BiologyClinical Biochemistry
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Biochemical findings in common inborn errors of metabolism

Verified

Marzia Pasquali, Gavin Monsen, Leah D’Aurora Richardson, Martha Alston et al.

Journal: American Journal of Medical Genetics Part C Seminars in Medical GeneticsYear: 2006Citations: 38

The application of tandem mass spectrometry (MS/MS) to newborn screening has led to the detection of patients with a wider spectrum of inborn errors of metabolism. A definitive diagnosis can often be established early enough to start treatment before symptoms appear. Here, we review common biochemic...

Life SciencesBiochemistry, Genetics and Molecular BiologyClinical Biochemistry
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HMGB1 is secreted by 3T3‐L1 adipocytes through JNK signaling and the secretion is partially inhibited by adiponectin

Verified

Toshiaki Shimizu, Munekazu Yamakuchi, Kamal Krishna Biswas, Bibek Aryal et al.

Journal: ObesityYear: 2016Citations: 36

OBJECTIVE: Obesity is a chronic inflammatory disease, and adipocytes contribute to obesity-associated inflammation by releasing inflammatory mediators. High mobility group box 1 (HMGB1), a highly conserved DNA-binding protein, mainly localized to cell nuclei, has been recently recognized as an innat...

Life SciencesBiochemistry, Genetics and Molecular BiologyClinical BiochemistryOpen Access
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Osteopenia and phenylketonuria

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D. J. Carson, L. G. Greeves, L Sweeney, Michael Crone

Journal: Pediatric RadiologyYear: 1990Citations: 36

Trabecular bone mineral content was assessed by quantitative computed tomography in eleven young adults with phenylketonuria who had been treated from early childhood with a diet restricted in natural protein and supplemented with amino acids, minerals and vitamins. There was a significant reduction...

Life SciencesBiochemistry, Genetics and Molecular BiologyClinical Biochemistry
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Age-Specific Cut-off Values of Amino Acids and Acylcarnitines for Diagnosis of Inborn Errors of Metabolism Using Liquid Chromatography Tandem Mass Spectrometry

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Suprovath Kumar Sarker, Md Tarikul Islam, Aparna Biswas, Golam Sarower Bhuyan et al.

Journal: BioMed Research InternationalYear: 2019Citations: 34

Liquid Chromatography tandem mass spectrometry (LC-MS/MS) is used for the diagnosis of more than 30 inborn errors of metabolisms (IEMs). Accurate and reliable diagnosis of IEMs by quantifying amino acids (AAs) and acylcarnitines (ACs) using LC-MS/MS systems depend on the establishment of age-specifi...

Life SciencesBiochemistry, Genetics and Molecular BiologyClinical BiochemistryOpen Access
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Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells

Verified

Changjun Chen, Songgang Wang, Jiying Chen, Xiaolin Liu et al.

Journal: FEBS Open BioYear: 2019Citations: 32

Escin, a natural triterpene saponin mixture obtained from the horse chestnut tree (Aesculus hippocastanum), has been used for the treatment of chronic venous insufficiency (CVI), hemorrhoids, and edema. However, it is unclear how escin protects against endothelial barrier dysfunction induced by pro-...

Life SciencesBiochemistry, Genetics and Molecular BiologyClinical BiochemistryOpen Access
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The effect of a liver protein synthesis inhibitor on plasma SAA levels in a model of accelerated amyloid deposition.

Verified

Robert Kisilevsky, Benson, Axelrad Ma, L Boudreau

Journal: PubMedYear: 1979Citations: 32

Animals treated with AgNO3 and amyloid-enhancing factor deposit large quantities of splenic amyloid in 48 hours. The kinetics of SAA production was examined in such a model in the presence and absence of an inhibitor of liver protein synthesis (ethionine). Ethionine had little effect on splenic prot...

Life SciencesBiochemistry, Genetics and Molecular BiologyClinical Biochemistry
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The association of oxidative stress biomarkers with type 2 diabetes mellitus: A systematic review and meta‐analysis

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Sujan Banik, Antara Ghosh

Journal: Health Science ReportsYear: 2021Citations: 31

BACKGROUND AND AIMS: Oxidative stress plays a major role in the development of type 2 diabetes mellitus (T2DM). However, there were controversial outcomes in the literature between the association of oxidative stress biomarkers and T2DM. The purpose of this systematic review and meta-analysis was to...

Life SciencesBiochemistry, Genetics and Molecular BiologyClinical BiochemistryOpen Access
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Poncirin, an orally active flavonoid exerts antidiabetic complications and improves glucose uptake activating PI3K/Akt signaling pathway in insulin resistant C2C12 cells with anti-glycation capacities

Verified

Md Yousof Ali, Sumera Zaib, Mizanur Rahman, Susoma Jannat et al.

Journal: Bioorganic ChemistryYear: 2020Citations: 29

Poncirin, a natural flavanone glycoside present abundantly in many citrus fruits, contains an extensive range of biological activities. However, the antidiabetic mechanism of poncirin is unexplored yet. In this study, we examined the anti-diabetic prospective of poncirin by evaluating its ability to...

Life SciencesBiochemistry, Genetics and Molecular BiologyClinical Biochemistry
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Relationship of Soluble RAGE with Insulin Resistance and Beta Cell Function during Development of Type 2 Diabetes Mellitus

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Subrata Kumar Biswas, Sabreena Mohtarin, Sonchita R. Mudi, Taznuva Anwar et al.

Journal: Journal of Diabetes ResearchYear: 2015Citations: 29

This study examined whether circulating levels of soluble receptor for advanced glycation end products (sRAGE) alter in prediabetes and correlate with insulin resistance (IR) and beta cell function in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM). Subjects without previous history ...

Life SciencesBiochemistry, Genetics and Molecular BiologyClinical BiochemistryOpen Access
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Renal Clearance of Essential Amino Acids: Threonine and Phenylalanine

Verified

Horace F. Russo, L. D. Wright, H. R. Skegs, Elizabeth K. Tillson et al.

Journal: Experimental Biology and MedicineYear: 1947Citations: 29

Renal clearance studies of threonine and phenylalanine in dogs have shown that the maximal rate of tubular re-absorption of these amino acids could not be exceeded by the administration of an amount of each amino acid sufficient to raise the plasma level to a value over 10 times that of the postabso...

Life SciencesBiochemistry, Genetics and Molecular BiologyClinical Biochemistry
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Serum soluble receptor for advanced glycation end products (sRAGE) is independently associated with cigarette smoking in non-diabetic healthy subjects

Verified

Subrata Kumar Biswas, Sonchita R. Mudi, Forhadul Hoque Mollah, Angelika Bierhaus et al.

Journal: Diabetes and Vascular Disease ResearchYear: 2013Citations: 28

This study was designed to explore the relationship between serum levels of soluble receptor for advanced glycation end products (sRAGE) and cigarette smoking in non-diabetic healthy subjects. A total of 98 non-diabetic, otherwise healthy male subjects were recruited. A fasting blood sample and medi...

Life SciencesBiochemistry, Genetics and Molecular BiologyClinical Biochemistry
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