Shiv Kumar Sarin, Chandan Kumar Kedarisetty, Zaigham Abbas, Deepak Amarapurkar et al.
The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set up in 2004 on acute-on-chronic liver failure (ACLF) was published in 2009. Due to the rapid advancements in the knowledge and available information, a consortium of members from co...
Shiv Kumar Sarin, Ashok Choudhury, Manoj K. Sharma, Rakhi Maiwall et al.
The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set up in 2004 on acute-on-chronic liver failure (ACLF) was published in 2009. With international groups volunteering to join, the “APASL ACLF Research Consortium (AARC)” was formed in...
Shiv Kumar Sarin, Ashish Kumar, John Almeida, Yogesh Chawla et al.
The Asian Pacific Association for the Study of the Liver (APASL) set up a working party on acute-on-chronic liver failure (ACLF) in 2004, with a mandate to develop consensus guidelines on various aspects of ACLF relevant to disease patterns and clinical practice in the Asia-Pacific region. Experts p...
Li Pei Ang, Pit Wei Ng, Yen Loong Lean, Vijay Kotra et al.
Herbal products are used globally for their perceived health benefits, and as a complement to alternative therapy to Western medicines. Herbal products can be beneficial, although they can also be harmful in several circumstances. Aristolochic acids (AA) are a compound that is abundant in Aristoloch...
APASL ACLF Working Party, Ashok Choudhury, Ankur Jindal, Rakhi Maiwall et al.
Background and aims Acute-on-chronic liver failure (ACLF) is a progressive disease associated with rapid clinical worsening and high mortality. Early prediction of mortality and intervention can improve patient outcomes. We aimed to develop a dynamic prognostic model and compare it with the existing...
Samir Kumar Sadhu, Emi Okuyama, Haruhiro Fujimoto, Masami Ishibashi
According to the traditional usage of the plant for antiinflammation and analgesia, Leucas aspera was tested for its prostaglandin (PG) inhibitory and antioxidant activities. The extract showed both activities, i.e., inhibition at 3 x 10(-4) g/ml against PGE(1)- and PGE(2)-induced contractions in gu...
Rajib Ahsan, K.M. Monirul Islam, Israt Jahan Bulbul, Ashik Musaddik et al.
2 Abstract: The methanol extracts of plant materials of some plants like Casuarina equisetifolia, Cajanus cajan, Glycosmis pentaphylla, Bixa orellana, Argemone mexicana, Physalis minima, Caesalpinia bonduc, belonging to the different family were studied for hepatoprotective activity against Swiss al...
Mohammed Hanif, Mahmoud Mobarak, Anne Ronan, Md. Anisur Rahman et al.
OBJECTIVE: To determine the cause of a large increase in the number of children with unexplained renal failure. DESIGN: Case-control study. SETTING: Children's hospital in Dhaka, Bangladesh. SUBJECTS: Cases were all 339 children with initially unexplained renal failure; controls were 90 children wit...
Tapan Behl, Gabriele Rocchetti, Swati Chadha, Gökhan Zengin et al.
To date, the leading causes of mortality and morbidity worldwide include viral infections, such as Ebola, influenza virus, acquired immunodeficiency syndrome (AIDS), severe acute respiratory syndrome (SARS) and recently COVID-19 disease, caused by the SARS-CoV-2 virus. Currently, we can count on a n...
Wiebke Albrecht, Franziska Kappenberg, Tim Brecklinghaus, Regina Stoeber et al.
Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In addition, currently available in vitro methods do not allow for the estimation of hepatotoxic doses or the determination of an acceptable daily intake (ADI). To overcome this limitation, an in vitro/in silico method...
MJ Haskell, GJ Handelman, JM Peerson, A. Daniel Jones et al.
Hepatic stores of vitamin A were estimated in 31 Bangladeshi surgical patients (15 males and 16 females) by the deuterated-retinol-dilution (DRD) technique and by analysis of the vitamin A concentration of a liver biopsy specimen obtained during previously scheduled abdominal surgery. Patients range...
Abdullah Al Nahain, Rownak Jahan, Mohammed Rahmatullah
Rheumatoid arthritis (RA) is an autoimmune disease particularly affecting elderly people which leads to massive bone destruction with consequent inflammation, pain, and debility. Allopathic medicine can provide only symptomatic relief. However, Zingiber officinale is a plant belonging to the Zingibe...
Tian Lan, Shuo Jiang, Jing Zhang, Qiqing Weng et al.
BACKGROUND AND AIMS: NAFLD is a key component of metabolic syndrome, ranging from nonalcoholic fatty liver to NASH, and is now becoming the leading cause of cirrhosis and HCC worldwide. However, due to the complex and unclear pathophysiological mechanism, there are no specific approved agents for tr...
Sabrina Afroz, M Alamgir, Majid Khan, S. Jabbar et al.
Paederia foetida L. is used as a remedy for diarrhoea and dysentery in Asia, but has not been investigated for its antidiarrhoeal properties. Antidiarrhoeal activity of 90% ethanol extract of Paederia foetida was investigated in this study using castor oil and magnesium sulphate-induced diarrhoea mo...
G. Deepa, Hans‐Peter Fuehrer, Peter Starzengrüber, Paul Swoboda et al.
Malaria is still a major threat in many parts of the world with resistance spreading to almost all classes of antimalarials. The limited arsenal of available antimalarial drugs emphasizes the urgent need for novel antimalarial compounds. Owing to the fact that novel leads from nature have traditiona...