Farhadul Islam, Vinod Gopalan, Simon Law, Johnny Tang et al.
Family with sequence similarity 134, member B (FAM134B) is an autophagy regulator of endoplasmic reticulum first discovered to be involved in the pathogenesis of esophageal squamous cell carcinoma (ESCC). The present study examined the functional behavior of FAM134B in cancer cells and the associati...
Lina Zgaga, Fiona O’Sullivan, Marie M. Cantwell, Liam Murray et al.
Vitamin D has been associated with reduced risk of many cancers, but evidence for esophageal cancer is mixed. To clarify the role of vitamin D, we performed a systematic review and meta-analysis to evaluate the association of vitamin D exposures and esophageal neoplasia, including adenocarcinoma, sq...
Kaichao Liu, Shunrong Ji, Yang Xu, Qingchun Diao et al.
The aims of this pilot study are to evaluate the feasibility, safety, and effectiveness of conducting an enhanced nutritional support pathway including extended preoperative nutritional support and one month home enteral nutrition (HEN) for patients who underwent enhanced recovery after esophagectom...
Adalberto Miranda‐Filho, Saman Warnakulasuriya
INTRODUCTION: This study provides an epidemiological description of cancer in the lip, oral cavity, and oropharynx in the South and South-East Asia region. METHODS: The number of new cases and deaths was extracted from the GLOBOCAN 2020 and the CI5 series. We present age-standardized incidence and m...
Kaiyan Li, Wenxuan Liang, Jessica Mavadia‐Shukla, Hyeon‐Cheol Park et al.
Endoscopic optical coherence tomography (OCT) is a noninvasive technology allowing for imaging of tissue microanatomies of luminal organs in real time. Conventional endoscopic OCT operates at 1300 nm wavelength region with a suboptimal axial resolution limited to 8-20 μm. In this paper, we present t...
Victoria H. Coupland, Jesper Lagergren, Julie Konfortion, William Allum et al.
BACKGROUND: This study investigated the variation in incidence of all, and six subgroups of, oesophageal and gastric cancer between ethnic groups. METHODS: Data on all oesophageal and gastric cancer patients diagnosed between 2001 and 2007 in England were analysed. Self-assigned ethnicity from the H...
Menghan Zhou, Yi‐Ping Li, Shaofeng Lin, Yanping Chen et al.
Background Histone methylation, as an essential pattern of posttranslational modifications, contributes to multiple cancer-related biological processes. Dysregulation of histone methylation is now considered a biomarker for cancer prognosis. Aims This study investigated and evaluated the potential r...
Pamela Cairns, B. G. McClure, Henry L. Halliday, M M Reid
Unlabelled A male infant born at 26 weeks gestation became unwell at 10 days of age with blood-stained pharyngeal aspirates. The chest radiograph revealed a feeding tube in the right pleural cavity, indicating a perforation of the thoracic oesophagus. The infant had had a chest drain inserted on the...
Weitao Shen, Derong Tang, Ping Wan, Zhenyan Peng et al.
It was previously believed that the microbial community in the esophagus was relatively stable, but it has been reported that different esophageal diseases have different microbial community characteristics. In this study, we recruited patients with esophageal squamous cell carcinoma (ESCC) and coll...
Mark G. O’Doherty, Neal D. Freedman, Albert R. Hollenbeck, Arthur Schatzkin et al.
The aim of our study was to investigate whether intakes of total fat and fat subtypes were associated with esophageal adenocarcinoma (EAC), esophageal squamous cell carcinoma (ESCC), gastric cardia or gastric noncardia adenocarcinoma. From 1995-1996, dietary intake data was reported by 494,978 parti...
Ahmad Sadeghi, Shahla Behmard, Hamid Shafiepoor, Elaine Zeighmani
The minimal yearly incidence of cancer of the esophagus in Fars Province in Southern Iran, based on hospital records in the capital city, is five to 10 times as high as the yearly incidence in Connecticut for the age group 15-44. Since these represent only a portion of cases among residents of the P...
Jessica L. Petrick, Nan Li, Lesley Anderson, Leslie Bernstein et al.
Background Diabetes is positively associated with various cancers, but its relationship with tumors of the esophagus/esophagogastric junction remains unclear. Methods Data were harmonized across 13 studies in the International Barrett’s and Esophageal Adenocarcinoma Consortium, comprising 2309 esoph...
Mosammat Suchana Nazrin, Nur E Jannatul Ferdous, Madhusudan Saha, Fahmi Iqbal Rabbi
Background: Diseases of gastrointestinal tract are a major cause of morbidity and mortality. Objective: This study was carried out to determine the spectrum of histopathological lesions of upper gastrointestinal tract.
 Methodology: This retrospective study was conducted in the Department of Pa...
Farhadul Islam, Vinod Gopalan, Simon Law, Alfred K. Lam et al.
Endothelial PAS domain-containing protein 1 (EPAS1) is an angiogenic factor and its implications have been reported in many cancers but not in esophageal squamous cell carcinoma (ESCC). Herein, we aim to examine the genetic and molecular alterations, clinical implications, and functional roles of EP...
Shaofeng Lin, Menghan Zhou, Yi‐Ping Li, Yanping Chen et al.
BACKGROUND: Esophageal cancer (EC) is the fourth most commonly diagnosed cancer in males and the fifth in females in China. Dysregulation methylation of histone is now considered a biomarker for cancer prognosis. METHODS: In this study, we focused on exploring the expression patterns of two represso...
Farhadul Islam, Johnny Tang, Vinod Gopalan, Alfred K. Lam
The aberrant DNA methylation has been noted to occur at promoter of tumor suppressor, cell adhesion, DNA repair, and other growth regulating genes during the progression of nonneoplastic esophageal mucosa to Barrett esophagus to esophageal adenocarcinoma. Methylation-mediated silencing of individual...
Mohammad Shariful Islam, Mohammad Abu Tareq Rony, Tipu Sultan
The accurate classification of endoscopic images is a challenging yet critical task in medical diagnostics, which directly affects the treatment and management of Gastrointestinal diseases. Misclassification can lead to incorrect treatment plans, adversely affecting patient outcomes. To address this...
Michael B. Cook, Shannon N. Wood, Paula L. Hyland, Patrick Caron et al.
Summary Previously, we observed strong positive associations between circulating concentrations of free testosterone and free dihydrotestosterone ( DHT ) in relation to Barrett's esophagus in a US male military population. To replicate these findings, we conducted a second study of sex steroid hormo...
Peter C. Black, Nimira Alimohamed, David M. Berman, Normand Blais et al.
INTRODUCTION: Advanced urothelial carcinoma has been challenging to treat due to limited treatment options, poor response rates, and poor long-term survival. New treatment options hold the promise of improved outcomes for these patients. METHODS: A multidisciplinary working group drafted a managemen...
Ye Zhu, Sachin Mulmi Shrestha, Ting Yu, Ruihua Shi
Background Refractory esophageal stricture is difficult to deal with. Some refractory stricture shows little response to now-existing endoscopic techniques. We assessed the efficacy of modified endoscopic radial incision and cutting method (M-RIC) for the treatment of refractory esophageal stricture...