James Perry, Normand Laperrière, Christopher J. O’Callaghan, Alba A. Brandes et al.
BACKGROUND: Glioblastoma is associated with a poor prognosis in the elderly. Survival has been shown to increase among patients 70 years of age or younger when temozolomide chemotherapy is added to standard radiotherapy (60 Gy over a period of 6 weeks). In elderly patients, more convenient shorter c...
Tadeusz Stadnik, C. Chaskis, Alex Michotte, Wael Shabana et al.
BACKGROUND AND PURPOSE: The purposes of this study were to find the role of diffusion-weighted MR imaging in characterizing intracerebral masses and to find a correlation, if any, between the different parameters of diffusion-weighted imaging and histologic analysis of tumors. The usefulness of diff...
Satya Siva Kishan Yalamarty, Nina Filipczak, Xiang Li, Md Abdus Subhan et al.
Glioblastoma multiforme (GBM) is a highly aggressive form of brain cancer that is difficult to treat due to its resistance to both radiation and chemotherapy. This resistance is largely due to the unique biology of GBM cells, which can evade the effects of conventional treatments through mechanisms ...
Md. Sahab Uddin, Abdullah Al Mamun, Badrah S. Alghamdi, Devesh Tewari et al.
Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be mild and slowly aggravated, although other symptoms might demonstrate it as an acute ailment. However, the precise mechanisms of ...
Md. Yousuf Ali, Claudia R. Oliva, Abu Shadat Mohammod Noman, Bryan G. Allen et al.
Ionizing radiation is a common and effective therapeutic option for the treatment of glioblastoma (GBM). Unfortunately, some GBMs are relatively radioresistant and patients have worse outcomes after radiation treatment. The mechanisms underlying intrinsic radioresistance in GBM has been rigorously i...
Gerald W. Marsa, Don R. Goffinet, Lucien J. Rubinstein, Malcolm A. Bagshaw
Curative radiotherapy was attempted in treating 256 patients with unresected or partially excised gliomas of the brain and spinal cord. Survival decreased with increasing age, reflecting the different incidences of tumor types in various age groups. Actuarial 5-year survival ranged from 85% for cere...
Andreas A. Argyriou, Susanna B. Park, Badrul Islam, Stefano Tamburin et al.
Chemotherapy-induced peripheral neurotoxicity (CIPN) is a common dose-limiting side effect of several anticancer medications. CIPN may involve multiple areas of the peripheral nervous system from the autonomic and dorsal root ganglia (DRG) to the axon and any peripheral nerve fibre type. Large diame...
Abhishta Bhandari, Rebecca Liong, Jarrad Koppen, Shashidhar Venkatesh Murthy et al.
<h3>BACKGROUND:</h3> Determination of <i>isocitrate dehydrogenase</i> (<i>IDH</i>) status and, if <i>IDH</i>-mutant, assessing 1p19q codeletion are an important component of diagnosis of World Health Organization grades II/III or lower-grade gliomas. This has led to research into noninvasively corre...
Aysha Ferdoushi, Nathan Griffin, Mark Marsland, Xiaoyue Xu et al.
Pancreatic cancer is a highly aggressive malignancy characterized by poor survival, recurrence after surgery and resistance to therapy. Nerves infiltrate the microenvironment of pancreatic cancers and contribute to tumor progression, however the clinicopathological significance of tumor innervation ...
Md. Abu Bakr Siddique, Shadman Sakib, Mohammad Mahmudur Rahman Khan, Abyaz Kader Tanzeem et al.
Diagnosing Brain Tumor with the aid of Magnetic Resonance Imaging (MRI) has gained enormous prominence over the years primarily in the field of medical science. Detection and/or partitioning of brain tumors solely with the aid of MR imaging is achieved at the cost of immense time and effort and dema...
Rajesh Balakrishnan, Rokeya Porag, Dewan Shamsul Asif, A. M. Rejaus Satter et al.
Primary CNS melanomas are rare and they constitute about 1% of all cases of melanomas and 0.07% of all brain tumors. These tumors are aggressive in nature and may metastasise to other organs. Till date less than 25 cases have been reported in the literature. The primary treatment for local intrapare...
Fabliha Ahmed Chowdhury, Md Kamal Hossain, AGM Mostofa, Maruf Mohammad Akbor et al.
Glioblastoma multiforme (GBM) is one of the most devastating brain tumors with median survival of one year and presents unique challenges to therapy because of its aggressive behavior. Current treatment strategy involves surgery, radiotherapy, immunotherapy, and adjuvant chemotherapy even though opt...
Geoffroy Andrieux, Tonmoy Das, Michaela Griffin, Jakob Straehle et al.
BACKGROUND: Spatiotemporal heterogeneity originating from genomic and transcriptional variation was found to contribute to subtype switching in isocitrate dehydrogenase-1 wild-type glioblastoma (GBM) prior to and upon recurrence. Fluorescence-guided neurosurgical resection utilizing 5-aminolevulinic...
S. M. Nuruzzaman Nobel, S M Masfequier Rahman Swapno, Md Babul Islam, AKM Azad et al.
Glioblastoma is the most common adult brain tumor, significantly impacts disability and mortality. Early and accurate diagnosis of glioma subtypes is essential, but manual categorization is challenging due to their complexity, prompting the need for automated solutions. We developed an innovative mi...
Mariyam Akter, Naoko Kaneko, Kazunobu Sawamoto
The ventricular-subventricular zone (V-SVZ) is located in the walls of the lateral ventricles and produces new neurons in the postnatal brain of mammals, including humans. Immature new neurons called "neuroblasts" generated by neural stem cells in the V-SVZ migrate toward their final destinations an...