Nga Thi Thuy, Huong T L Vu, Chuc T K Nguyen, Sureeporn Punpuing et al.
BACKGROUND: Antimicrobial misuse is common in low-income and middle-income countries (LMICs), and this practice is a driver of antibiotic resistance. We compared community-based antibiotic access and use practices across communities in LMICs to identify contextually specific targets for intervention...
Silke Reinartz, Tim Schumann, Florian Finkernagel, Annika Wortmann et al.
Ovarian cancer is typically accompanied by the occurrence of malignant ascites containing large number of macrophages. It has been suggested that these tumor-associated macrophages (TAMs) are skewed to alternative polarization (M2) and thereby play an essential role in therapy resistance and metasta...
Iftekhar Ahmed, Md. Bodiuzzaman Rabbi, Sakina Sultana
BACKGROUND: Antibiotic resistance (ABR) is a worldwide problem and Bangladesh is a major contributor to this owing to its poor healthcare standards, along with the misuse and overuse of antibiotics. This systematic review was conducted to summarize the present scenario of ABR in Bangladesh, to ident...
Ray Borrow, Pedro Alarcón, Josefina Carlos, Dominique A. Caugant et al.
INTRODUCTION: The 2015 Global Meningococcal Initiative (GMI) meeting discussed the global importance of meningococcal disease (MD) and its continually changing epidemiology. Areas covered: Although recent vaccination programs have been successful in reducing incidence in many countries (e.g. Neisser...
Samba O. Sow, Khitam Muhsen, Dilruba Nasrin, William C. Blackwelder et al.
BACKGROUND: The importance of Cryptosporidium as a pediatric enteropathogen in developing countries is recognized. METHODS: Data from the Global Enteric Multicenter Study (GEMS), a 3-year, 7-site, case-control study of moderate-to-severe diarrhea (MSD) and GEMS-1A (1-year study of MSD and less-sever...
Kelly Thornber, David W. Verner–Jeffreys, Steve Hinchliffe, Muhammad Meezanur Rahman et al.
Antimicrobial resistance (AMR) is a growing threat to global public health, and the overuse of antibiotics in animals has been identified as a major risk factor. With high levels of international trade and direct connectivity to the aquatic environment, shrimp aquaculture may play a role in global A...
M. JOHN ALBERT, M. Ansaruzzaman, Kaisar A. Talukder, Ashok K. Chopra et al.
Aeromonads are causative agents of a number of human infections. Even though aeromonads have been isolated from patients suffering from diarrhea, their etiological role in gastroenteritis is unclear. In spite of a number of virulence factors produced by Aeromonas species, their association with diar...
Felicia M. T. Lewis, Kyle T. Bernstein, Sevgi O. Aral
The vaginal microbiota has great significance in maintaining vaginal health and protecting the host from disease. Recent advances in molecular techniques and informatics allow researchers to explore microbial composition in detail and to compare the structure of vaginal microbial communities with be...
T. K. Goswami, Mithilesh Singh, Manish Dhawan, Saikat Mitra et al.
Autoimmune diseases are caused when immune cells act against self-protein. This biological self-non-self-discrimination phenomenon is controlled by a distinct group of lymphocytes known as regulatory T cells (Tregs), which are key inflammatory response regulators and play a pivotal role in immune to...
Brian Godman, Abiodun Egwuenu, Mainul Haque, Oliver Ombeva Malande et al.
Antimicrobial resistance (AMR) is a high priority across countries as it increases morbidity, mortality and costs. Concerns with AMR have resulted in multiple initiatives internationally, nationally and regionally to enhance appropriate antibiotic utilization across sectors to reduce AMR, with the o...
Elizabeth T. Rogawski McQuade, James A Platts-Mills, Jessica C. Seidman, Sushil John et al.
Antibiotics can be a lifesaving treatment for children with bacterial infections and are the most commonly prescribed therapy among all medications given to children. Furthermore, both at the individual and population levels, antibiotic overuse drives the development and transmission of antimicrobia...
Motohiro Iseki, Ibne Karim M. Ali, Momammad B. Hossain, Viqar Zaman et al.
Since the genotype of human Blastocystis hominis isolates is highly polymorphic, PCR-based genotype classification using known sequenced-tagged site (STS) primers would allow the identification or classification of different genotypes. Five populations of human B. hominis isolates obtained from Japa...
Mohammad Nurul Amin, Shafayet Ahmed Siddiqui, Md Ibrahim, Md Lukman Hakim et al.
Inflammatory cytokines are highly inducible small glycoproteins or regulatory proteins of low molecular weight secreted by different cell types. They regulate intercellular communication and mediate a number of physiological functions in the human immune system. Numerous prospective studies report t...
Robert F. Massung, Li‐Ing Liu, Jin Qi, Janice C. Knight et al.
We analyzed the 186,102 base pairs (bp) that constitute the entire DNA genome of a highly virulent variola virus isolated from Bangladesh in 1975. The linear, double-stranded molecule has relatively small (725 bp) inverted terminal repeat (ITR) sequences containing three 69-bp direct repeat elements...
Christine D. Palmer, Amy Rappaport, Matthew J. Davis, Meghan G. Hart et al.
Checkpoint inhibitor (CPI) therapies provide limited benefit to patients with tumors of low immune reactivity. T cell-inducing vaccines hold promise to exert long-lasting disease control in combination with CPI therapy. Safety, tolerability and recommended phase 2 dose (RP2D) of an individualized, h...