Michael S. Kramer, Ritsuko Kakuma
BACKGROUND: Although the health benefits of breastfeeding are widely acknowledged, opinions and recommendations are strongly divided on the optimal duration of exclusive breastfeeding. Since 2001, the World Health Organization has recommended exclusive breastfeeding for six months. Much of the recen...
K Zaman, Dang Duc Anh, John C. Victor, Sunheang Shin et al.
Background Rotavirus vaccine has proved effective for prevention of severe rotavirus gastroenteritis in infants in developed countries, but no efficacy studies have been done in developing countries in Asia. We assessed the clinical efficacy of live oral pentavalent rotavirus vaccine for prevention ...
Mercedes de Onís, Adelheid W. Onyango, Elaine Borghi, Cutberto Garza et al.
OBJECTIVES: To compare growth patterns and estimates of malnutrition based on the World Health Organization (WHO) Child Growth Standards ('the WHO standards') and the National Center for Health Statistics (NCHS)/WHO international growth reference ('the NCHS reference'), and discuss implications for ...
Shams El Arifeen, Robert E. Black, Gretchen Antelman, Abdullah H Baqui et al.
OBJECTIVES: To describe breastfeeding practices and investigate the influence of exclusive breastfeeding in early infancy on the risk of infant deaths, especially those attributable to respiratory infections (ARI) and diarrhea. METHODS: A prospective observational study was conducted on a birth coho...
Md. Abul Kalam Azad, Manobendro Sarker, Dan Wan
Probiotics confer immunological protection to the host through the regulation, stimulation, and modulation of immune responses. Researchers have shifted their attention to better understand the immunomodulatory effects of probiotics, which have the potential to prevent or alleviate certain pathologi...
M. Nazmul Huda, Zachery T. Lewis, Karen M. Kalanetra, Mamunur Rashid et al.
OBJECTIVE: Oral vaccine efficacy is low in less-developed countries, perhaps due to intestinal dysbiosis. This study determined if stool microbiota composition predicted infant oral and parenteral vaccine responses. METHODS: The stool microbiota of 48 Bangladeshi infants was characterized at 6, 11, ...
Amy M. Ehrlich, Alline R. Pacheco, Bethany M. Henrick, Diana H. Taft et al.
BACKGROUND: Bifidobacterium longum subsp. infantis (B. infantis) is a commensal bacterium that colonizes the gastrointestinal tract of breast-fed infants. B. infantis can efficiently utilize the abundant supply of oligosaccharides found in human milk (HMO) to help establish residence. We hypothesize...
Margaret Kosek, Tahmeed Ahmed, Zulfiqar A Bhutta, Laura E. Caulfield et al.
BACKGROUND: Environmental enteropathy (EE), the adverse impact of frequent and numerous enteric infections on the gut resulting in a state of persistent immune activation and altered permeability, has been proposed as a key determinant of growth failure in children in low- and middle-income populati...
Karen L. Kotloff, Dilruba Nasrin, William C. Blackwelder, Yukun Wu et al.
BACKGROUND: Diarrheal diseases remain a leading cause of illness and death among children younger than 5 years in low-income and middle-income countries. The Global Enteric Multicenter Study (GEMS) has described the incidence, aetiology, and sequelae of medically attended moderate-to-severe diarrhoe...
Victor Owino, Tahmeed Ahmed, Michael Freemark, Paul Kelly et al.
Approximately 25% of the world’s children aged <5 years have stunted growth, which is associated with increased mortality, cognitive dysfunction, and loss of productivity. Reducing by 40% the number of stunted children is a global target for 2030. The pathogenesis of stunting is poorly unders...
Indu Sharma, Abbey Byrne
BACKGROUND: Early or timely initiation of breastfeeding is crucial in preventing newborn deaths and influences childhood nutrition however remains low in South Asia and the factors and barriers warrant greater consideration for improved action. This review synthesises the evidence on factors and bar...
Shafiqul Alam Sarker, Thomas Casswall, Dilip Mahalanabis, NUR H. ALAM et al.
BACKGROUND: Oral ingestion of immunoglobulins in humans has been shown to be effective as prophylaxis against enteric infections. However, its therapeutic effect in children with infectious diarrhea has hitherto not been proven. We treated children with rotavirus diarrhea with immunoglobulins extrac...
Kenneth H. Brown, Naheed Ahmed Akhtar, Alastair D. Robertson, Mohammad Wahid Ahmed
Longitudinal studies of the nutritional status of 60 lactating Bangladeshi mothers from an underprivileged, periurban community and of the quantity and composition of their milk were completed to determine the relationships between maternal nutritional status and lactational capacity. Daily milk pro...
M. Nazmul Huda, Shaikh Meshbahuddin Ahmad, Jahangir Alam, Afsana Khanam et al.
BACKGROUND: The intestinal microbiome in early infancy affects immunologic development and thus may affect vaccine memory, though few prospective studies have examined such associations. We examined the association of Bifidobacterium levels in early infancy with memory responses to early vaccination...
Rubhana Raqib, Dewan S Alam, Protim Sarker, Shaikh Meshbahuddin Ahmad et al.
Background Low birth weight is generally an outcome of a fetal insult or nutritional insufficiency. Recent studies have shown that such exposure early in life may have long-term implications for later immunocompetence and susceptibility to infectious diseases. Objective We aimed to investigate the e...