Premature ovarian failure is the term usually used to describe women aged younger than 40 years who present with amenorrhea, hypergonadotropinism, and hypoestrogenism. Such women may ovulate and even conceive after the diagnosis is made, so it may be more appropriate to refer to these patients as ha...
Mohammad Nurul Amin, Shafayet Ahmed Siddiqui, Md Ibrahim, Md Lukman Hakim et al.
Inflammatory cytokines are highly inducible small glycoproteins or regulatory proteins of low molecular weight secreted by different cell types. They regulate intercellular communication and mediate a number of physiological functions in the human immune system. Numerous prospective studies report t...
Md. Sahab Uddin, Md. Tanvir Kabir, Abdullah Al Mamun, Mohamed M. Abdel‐Daim et al.
Alzheimer's disease (AD) is an immutable neurodegenerative disease featured by the two hallmark brain pathologies that are the extracellular amyloid ß (Aß) and intraneuronal tau protein. People carrying the APOE4 allele are at high risk of AD concerning the ones carrying the ε3 allele, while the ε2 ...
Zhi Wang, Daozhan Yu, Mengqiao Wang, Qilong Wang et al.
Elabela (ELA) or Toddler is a recently discovered hormone which is required for normal development of heart and vasculature through activation of apelin receptor (APJ), a G protein-coupled receptor (GPCR), in zebrafish. The present study explores whether the ELA-APJ signaling pathway is functional i...
Abdur Rauf, Ahmed Olatunde, Muhammad Imran, Fahad A. Alhumaydhi et al.
Background Honokiol is a pleiotropic compound which been isolated from Magnolia species such as Magnolia grandiflora and Magnolia dealbata. Magnolia species Magnolia grandiflora is used in traditional medicine for the treatment of various diseases. Purpose The objective of this review is to summariz...
Lars Verschuren, Teake Kooistra, Jürgen Bernhagen, Peter J. Voshol et al.
Chronic inflammation in white adipose tissue (WAT) is positively associated with obesity, insulin resistance (IR) and the development of type 2 diabetes. The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is an essential, upstream component of the inflammatory cascade. This st...
Md Habibur Rahman, Silong Peng, Xiyuan Hu, Chen Chen et al.
Neurological diseases (NDs) are progressive disorders, the progression of which can be significantly affected by a range of common diseases that present as comorbidities. Clinical studies, including epidemiological and neuropathological analyses, indicate that patients with type 2 diabetes (T2D) hav...
Chandan Kumar Sarkar, Cristina Quispe, Sarmin Jamaddar, Rajib Hossain et al.
Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. It is known for its inflammatory and immunological potentials. This review aims to sketch a current scenario on its therapeutic activities on the basis of sc...
Julia Kim, Daniel S. Roberts, Yinghui Hu, Garrick C. Lau et al.
Regulation of gene expression via brain-derived neurotrophic factor (BDNF) is critical to the development of the nervous system and may well underlie cognitive performance throughout life. We now describe a mechanism by which BDNF can exert its effects on postsynaptic receptor populations that may h...
Abdullah Al Mamun, Md. Sahab Uddin, Md. Fahim Bin Bashar, Sonia Zaman et al.
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that causes chronic cognitive dysfunction. Most of the AD cases are late onset, and the apolipoprotein E ( APOE ) isoform is a key genetic risk factor. The APOE gene has 3 key alleles in humans including APOE2 , APOE3 , and APOE4 . ...
Md. Mominur Rahman, Xiaoyan Wang, Md. Rezaul Islam, Shopnil Akash et al.
Natural substances originating from plants have long been used to treat neurodegenerative disorders (NDs). Parkinson's disease (PD) is a ND. The deterioration and subsequent cognitive impairments of the midbrain nigral dopaminergic neurons distinguish by this characteristic. Various pathogenic mecha...
Elizabeth Thompson, M Pembrey
Five children in whom a diagnosis of Seckel syndrome had previously been made were re-examined in the genetic unit. One child had classical Seckel syndrome, a sib pair had the features of the syndrome with less severe short stature, and in two children the diagnosis was not confirmed. Seckel syndrom...
Zhinian Lei, Yu Jiang, Tao Li, Jianbao Zhu et al.
Glial cell line-derived neurotrophic factor (GDNF) and its receptor GFRα1 have been implicated in the survival of ventral midbrain dopaminergic (DA) neurons, but the molecular mechanisms bywhich GDNF generates DA neurons in grafted midbrain-derived neural stem cells (mNSCs) are not understood. Midbr...
Rakesh Arya, A. K. M. Ariful Haque, Hemlata Shakya, Md. Masum Billah et al.
Parkinson's disease (PD) is a progressive neurological disease that causes both motor and nonmotor symptoms. While our understanding of putative mechanisms has advanced significantly, it remains challenging to verify biomarkers with sufficient evidence for regular clinical use. Clinical symptoms are...
Md. Sahab Uddin, Sharifa Hasana, Md. Farhad Hossain, Md. Siddiqul Islam et al.
Alzheimer's disease (AD) is the most common form of dementia in the elderly and this complex disorder is associated with environmental as well as genetic factors. Early-onset AD (EOAD) and late-onset AD (LOAD, more common) are major identified types of AD. The genetics of EOAD is extensively underst...