Paul Hoskins, Elizabeth A. Eisenhauer, Sandra Beare, Manas Pratim Roy et al.
PURPOSE: As topotecan is S-phase-specific, its efficacy is likely schedule-dependent. Therefore, a randomized study using a "pick the winner" design was undertaken to compare two schedules in patients with recurrent ovarian cancer. PATIENTS AND METHODS: Patients with recurrent epithelial ovarian can...
Asima Mukhopadhyay, Elizabeth Ruth Plummer, Ahmed Elattar, San Soohoo et al.
Up to 50% of epithelial ovarian cancers (EOC) display defects in the homologous recombination (HR) pathway. We sought to determine the ramifications of the homologous recombination-deficient (HRD) status on the clinicopathologic features, chemotherapy response, and survival outcomes of patients with...
Sayma Alam Suha, Muhammad Nazrul Islam
Polycystic ovary syndrome (PCOS) is the most prevalent endocrinological abnormality and one of the primary causes of anovulatory infertility in women globally. The detection of multiple cysts using ovary ultrasonograpgy (USG) scans is one of the most reliable approach for making an accurate diagnosi...
Salima Akter, Md. Ataur Rahman, Mohammad Nazmul Hasan, Hajara Akhter et al.
Aggressive and recurrent gynecological cancers are associated with worse prognosis and a lack of effective therapeutic response. Ovarian cancer (OC) patients are often diagnosed in advanced stages, when drug resistance, angiogenesis, relapse, and metastasis impact survival outcomes. Currently, surgi...
Saikat Mitra, Mashia Subha Lami, Avoy Ghosh, Rajib Das et al.
In recent years, hormone therapy has been shown to be a remarkable treatment option for cancer. Hormone treatment for gynecological cancers involves the use of medications that reduce the level of hormones or inhibit their biological activity, thereby stopping or slowing cancer growth. Hormone treat...
Md. Martuza Ahamad, Sakifa Aktar, Md. Jamal Uddin, Tasnia Rahman et al.
One of the common types of cancer for women is ovarian cancer. Still, at present, there are no drug therapies that can properly cure this deadly disease. However, early-stage detection could boost the life expectancy of the patients. The main aim of this work is to apply machine learning models alon...
Hiya Islam, Jaasia Masud, Yushe Nazrul Islam, Fahim Kabir Monjurul Haque
Polycystic ovary syndrome is the most common endocrine disorder in women of reproductive age, which is still incurable. However, the symptoms can be successfully managed with proper medication and lifestyle interventions. Despite its prevalence, little is known about its etiology. In this review art...
A.K.M. Salman Hosain, Md Humaion Kabir Mehedi, Irteza Enan Kabir
Polycystic Ovary Syndrome (PCOS) is an endrocrinological dysfunction prevalent among women of reproductive age. PCOS is a combination of syndromes caused by an excess of androgens — a group of sex hormones — in women. Syndromes including acne, alopecia, hirsutism, hyperandrogenaemia, oligoovulation,...
Atif A Hashmi, Samreen Naz, Muhammad Muzzammil Edhi, Naveen Faridi et al.
BACKGROUND: Ovarian neoplasms are a heterogeneous group of tumors including surface epithelial, germ cell and sex cord stromal tumors with a subset having low malignant potential (borderline tumors). While the surgical management plan differs in different categories of tumors, preoperative diagnosis...
James Liu, Kristine Zanotti
Adnexal masses are commonly encountered in gynecologic practice and often present both diagnostic and management challenges. This is partly because of the fact that the majority of adnexal masses that are identified represent benign entities that do not necessarily require active intervention, yet a...
Hee Seung Kim, Yong Sang Song
The International Federation of Gynecology and Obstetrics (FIGO), the first organization to develop a staging system of gynecologic cancer, became the official patron of the Annual Report for the development and changes of gynecologic cancer classification and staging since 1958.1 Thereafter, FIGO s...
John R. van Nagell, Rachel W. Miller
Data from screening trials indicate that a significant percent of asymptomatic women older than 50 years of age will develop ovarian abnormalities that are detectable by ultrasonography. Most of these abnormalities are benign, and many will resolve spontaneously. However, the risk of ovarian cancer,...
Damian McManus, Eric P.H. Yap, P Maxwell, S.E. Hilary Russell et al.
The aim of this investigation was to study the prevalence of p53 gene mutations and allelic deletions in ovarian cancer and the relationship between these events and p53 expression. Genomic p53 was amplified by the polymerase chain reaction (PCR) from paraffin-embedded sections of tumour and non-tum...
Jan Hauspy, Mario Beiner, Ian Harley, Barry P. Rosen et al.
Purpose To review the role of adjuvant radiotherapy (RT) in the outcome and recurrence patterns of granulosa cell tumors (GCTs) of the ovary. Methods and materials The records of all patients with GCTs referred to the Princess Margaret Hospital University Health Network between 1961 and 2006 were re...
Bruce R. Parker, Ronald A. Castellino, Zvi Fuks, Malcolm A. Bagshaw
Although therapeutic options in ovarian carcinoma depend upon the extent of disease little attention has been paid to lymphography for pretreatment staging. From 1967 through 1972, 69 patients with previously untreated ovarian malignancy underwent lymphography. Prior to lymphography, 19% of the pati...