James Perry, Normand Laperrière, Christopher J. O’Callaghan, Alba A. Brandes et al.
BACKGROUND: Glioblastoma is associated with a poor prognosis in the elderly. Survival has been shown to increase among patients 70 years of age or younger when temozolomide chemotherapy is added to standard radiotherapy (60 Gy over a period of 6 weeks). In elderly patients, more convenient shorter c...
Samuel A.J. Trammell, Mark S. Schmidt, Benjamin J. Weidemann, Philip Redpath et al.
Abstract Nicotinamide riboside (NR) is in wide use as an NAD + precursor vitamin. Here we determine the time and dose-dependent effects of NR on blood NAD + metabolism in humans. We report that human blood NAD + can rise as much as 2.7-fold with a single oral dose of NR in a pilot study of one indiv...
Joana M. Senra, Brian A. Telfer, Kim E. Cherry, Cian M. McCrudden et al.
PARP-1 is a critical enzyme in the repair of DNA strand breaks. Inhibition of PARP-1 increases the effectiveness of radiation in killing tumor cells. However, although the mechanism(s) are well understood for these radiosensitizing effects in vitro, the underlying mechanism(s) in vivo are less clear...
Paul Hoskins, Elizabeth A. Eisenhauer, Sandra Beare, Manas Pratim Roy et al.
PURPOSE: As topotecan is S-phase-specific, its efficacy is likely schedule-dependent. Therefore, a randomized study using a "pick the winner" design was undertaken to compare two schedules in patients with recurrent ovarian cancer. PATIENTS AND METHODS: Patients with recurrent epithelial ovarian can...
Asima Mukhopadhyay, Elizabeth Ruth Plummer, Ahmed Elattar, San Soohoo et al.
Up to 50% of epithelial ovarian cancers (EOC) display defects in the homologous recombination (HR) pathway. We sought to determine the ramifications of the homologous recombination-deficient (HRD) status on the clinicopathologic features, chemotherapy response, and survival outcomes of patients with...
Salima Akter, Md. Ataur Rahman, Mohammad Nazmul Hasan, Hajara Akhter et al.
Aggressive and recurrent gynecological cancers are associated with worse prognosis and a lack of effective therapeutic response. Ovarian cancer (OC) patients are often diagnosed in advanced stages, when drug resistance, angiogenesis, relapse, and metastasis impact survival outcomes. Currently, surgi...
Catherine Wilson, Timothy R. Wilson, Patrick G. Johnston, Daniel B. Longley et al.
Chemotherapy-induced interleukin-8 (IL-8) signaling reduces the sensitivity of prostate cancer cells to undergo apoptosis. In this study, we investigated how endogenous and drug-induced IL-8 signaling altered the extrinsic apoptosis pathway by determining the sensitivity of LNCaP and PC3 cells to ad...
Lei Wang, Changyong Yang, Chengying Xie, Jiahua Jiang et al.
Poly( ADP ‐ribose) polymerase ( PARP ) enzymes play an important role in repairing DNA damage and maintaining genomic stability. Olaparib, the first‐in‐class PARP inhibitor, has shown remarkable clinical benefits in the treatment of BRCA ‐mutated ovarian or breast cancer. However, the undesirable he...
Md. Mominur Rahman, Tapan Behl, Md. Rezaul Islam, Md Noor A Alam et al.
Immunotherapy, which stimulates the body's immune system, has received a considerable amount of press in recent years because of its powerful benefits. Cancer immunotherapy has shown long-term results in patients with advanced disease that are not seen with traditional chemotherapy. Immune checkpoin...
Fahad Imtiaz Rahman, Sadia Afruz Ether, Md. Rabiul Islam
Article The “Delta Plus” COVID-19 variant has evolved to become the next potential variant of concern: mutation history and measures of prevention was published on January 1, 2022 in the journal Journal of Basic and Clinical Physiology and Pharmacology (volume 33, issue 1).
Saria Farheen, Yusha Araf, Yan‐Dong Tang, Chunfu Zheng
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), since its outbreak in December 2019, has been capable of continuing the pandemic by mutating itself into different variants. Mass vaccinations, antibiotic treatment therapy, herd immunity, and preventive measures have reduced the disease'...
Alex Thomas, Elizabeth Rajesh, Dharmendra Kumar
Tinospora crispa is a medicinal plant belonging to the botanical family Menispermiaceae. The plant is widely distributed in Southeast Asia and the northeastern region of India. A related species Tinospora cordifolia is used in Ayurveda for treating a large spectrum of diseases. Traditional healers o...
Eileen E. Parkes, Richard D. Kennedy
UNLABELLED: : High-grade serous ovarian cancer is characterized by genomic instability, with one half of all tumors displaying defects in the important DNA repair pathway of homologous recombination. Given the action of poly(ADP-ribose) polymerase (PARP) inhibitors in targeting tumors with deficienc...
Salma Parvin, Md. Siddiqul Islam, Mir Md. Abdullah Al-Mamun, Mohammad Safiqul Islam et al.
Purpose Breast cancer is considered as the most frequent female malignancy. Altered gene expressions due to genetic polymorphisms in the BRCA1, BRCA2, RAD51, and HER2 contribute toward the development of breast cancer, and yet, no such type of study has been conducted in the Bangladeshi population. ...
Dapinder Kaur, Tapan Behl, Aayush Sehgal, Sukhbir Singh et al.
During the last three decades, recombinant DNA technology has produced a wide range of hematopoietic and neurotrophic growth factors, including erythropoietin (EPO), which has emerged as a promising protein drug in the treatment of several diseases. Cumulative studies have recently indicated the neu...