Ian Gilron
Neuropathic pain, caused by various central and peripheral nerve disorders, is especially problematic because of its severity, chronicity and resistance to simple analgesics. The condition affects 2%-3% of the population, is costly to the health care system and is personally devastating to the peopl...
Alok Kumar Paul, Craig M. Smith, Mohammed Rahmatullah, Veeranoot Nissapatorn et al.
Opioids are widely used as therapeutic agents against moderate to severe acute and chronic pain. Still, these classes of analgesic drugs have many potential limitations as they induce analgesic tolerance, addiction and numerous behavioural adverse effects that often result in patient non-compliance....
Shannon M. Smith, Robert H. Dworkin, Dennis C. Turk, Ralf Baron et al.
Valid and reliable biomarkers can play an important role in clinical trials as indicators of biological or pathogenic processes or as a signal of treatment response. Currently, there are no biomarkers for pain qualified by the US Food and Drug Administration or the European Medicines Agency for use ...
Kjersti Mørkrid, Liaquat Ali, Akhtar Hussain
Aims/Hypothesis: The purpose of the study is to estimate the prevalence and risk factors for diabetic peripheral neuropathy (DPN) in type 2 diabetic outpatients at the BIRDEM hospital, Bangladesh. Materials and Methods: Type 2 diabetic outpatients, diagnosed 5-11 years prior to the investigation wer...
Raymond D. Hubbard, Beth A. Winkelstein
STUDY DESIGN: An in vivo rat model of transient cervical nerve root compression. OBJECTIVES: To investigate the potential for cervical nerve root compression to produce behavioral hypersensitivity and examine its dependence on compression. SUMMARY OF BACKGROUND DATA: Clinically, nerve root injury ha...
Jens Schouenborg, B.H. Sjo¨lund
An antagonist to amino acid evoked excitation, gamma-D-glutamylglycine (gamma-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) ...
Keith Murray, R. C. L. FENELEY
A single blind trial of the effect of opioid blockade on lower urinary tract function, assessed urodynamically, is reported. Twenty patients (10 male, 10 female) were studied by filling and voiding cystometry and urethral pressure profilometry before and after the administration of a potent opioid a...
Hideo Kobayashi, Takuya Kitamura, Miho Sekiguchi, Yoshimi Homma et al.
STUDY DESIGN: We investigated involvement of EphB/ephrinB system in neuropathic pain. OBJECTIVE: Using immunoblotting, immunohistochemistry, and RNA interference techniques, we examined the expression levels of EphB receptors and ephrinB ligands in neuropathic pain. We also explored the effect of ep...
Ambia Khatun, Mohammad Zafar Imam, Md. Sohel Rana
BACKGROUND: Persicaria hydropiper (Linn.) Delarbre is a common plant of Polygonaceae family commonly called Bishkatali in Bangladesh. Leaves of the plant are traditionally used in the treatment of rheumatic pain, gout, and skin diseases such as ringworms, scabies, boils, abscesses, carbuncles, bites...
Akira Onda, Shoji Yabuki, Shinichi Kikuchi
STUDY DESIGN: The effect of an anti-tumor necrosis factor alpha (anti-TNFalpha) antibody on abnormal discharges caused by application of nucleus pulposus to the nerve root was investigated in an electrophysiologic study. OBJECTIVES: To assess whether inhibition of TNFalpha can reduce nucleus pulposu...
Elizabeth G. VanDenKerkhof, Larry Stitt, Alexander J. Clark, Allan Gordon et al.
OBJECTIVES: Several tools have been developed to screen for neuropathic pain. This study examined the sensitivity of the Douleur Neuropathique en 4 Questions (DN4) in screening for various neuropathic pain syndromes. MATERIALS AND METHODS: This prospective observational study was conducted in 7 Cana...
Aki Hietaharju, Richard Croft, Rezaul Alam, Paul Birch et al.
The existence of chronic neuropathic pain in treated leprosy has received scant attention. We describe the clinical findings of 16 patients with multibacillary leprosy who had chronic stimulus-independent pain despite finishing their treatment. With confirmation, our results could be of importance i...
Md. Sahab Uddin, Abdullah Al Mamun, Md. Ataur Rahman, Md. Tanvir Kabir et al.
Neuropathic pain (NP) is the result of irregular processing in the central or peripheral nervous system, which is generally caused by neuronal injury. The management of NP represents a great challenge owing to its heterogeneous profile and the significant undesirable side effects of the frequently p...
P. James B. Dyck, James W. Albers, James Wolfe, Charles F. Bolton et al.
INTRODUCTION: The aim of this study was to test the proficiency (accuracy among evaluators) of measured attributes of nerve conduction (NC). METHODS: Expert clinical neurophysiologists, without instruction or consensus development, from 4 different medical centers, independently assessed 8 attribute...
Nestor N. Jiménez-Vargas, Yang Yu, Dane D. Jensen, Diana Bok et al.
OBJECTIVE: The effectiveness of µ-opioid receptor (MOPr) agonists for treatment of visceral pain is compromised by constipation, respiratory depression, sedation and addiction. We investigated whether a fentanyl analogue, (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), whi...