Akram Pourshams, Sadaf G Sepanlou, Kevin S Ikuta, Catherine Bisignano et al.
BACKGROUND: Worldwide, both the incidence and death rates of pancreatic cancer are increasing. Evaluation of pancreatic cancer burden and its global, regional, and national patterns is crucial to policy making and better resource allocation for controlling pancreatic cancer risk factors, developing ...
Nurshad Ali
The outbreak of coronavirus disease-2019 (COVID-19) is an emerging global health threat. The healthcare workers are facing challenges in reducing the severity and mortality of COVID-19 across the world. Severe patients with COVID-19 are generally treated in the intensive care unit, while mild or non...
Alexander Schneider, Amitabh Suman, Livio Rossi, M. Michael Barmada et al.
Background & aims Tropical pancreatitis, including tropical calcific pancreatitis and fibrocalculous pancreatic diabetes, is endemic in parts of Asia and Africa. In a preliminary study, we found serine protease inhibitor, Kazal type 1 (SPINK1) mutations in 6 of 8 patients with fibrocalculous pancrea...
Zahid Hassan, Viswanathan Mohan, Liaquat Ali, Rebecca Allotey et al.
Fibrocalculous pancreatic diabetes (FCPD) is a secondary cause of diabetes due to chronic pancreatitis. Since the N34S variant of the SPINK1 trypsin inhibitor gene has been found to partially account for genetic susceptibility to chronic pancreatitis, we used a family-based and case-control approach...
Raquibul Hasan, Shoumen Lasker, Ahasanul Hasan, Farzana Zerin et al.
Diabetes is a leading cause of chronic kidney disease, and the high prevalence of sympathetic nervous system (SNS) hyperactivity in diabetic patients makes them further susceptible to SNS-mediated oxidative stress and accelerated kidney damage. Here, we investigated if canagliflozin can reverse isop...
Rahanuma Raihanu Kathak, Abu Hasan Sumon, Noyan Hossain Molla, Mahmudul Hasan et al.
Dyslipidemia, a major contributor to cardiovascular diseases, is rapidly increasing in Asian countries including Bangladesh. In addition to the cardiovascular system, abnormal lipid levels are also known to cause complications in renal and hepatic systems. The data regarding dyslipidemia and its rel...
Livio Rossi, Roland H. Pfützer, Shahana Parvin, Liaquat Ali et al.
Background/aims Tropical pancreatitis (TP) refers to a severe type of idiopathic chronic pancreatitis that develops in children in tropical regions of Africa and southern Asia. Phenotypically TP is subdivided into fibrocalculous pancreatic diabetes (FCPD) and tropical calcific pancreatitis without d...
Madhu S. Malo
Mice deficient in intestinal alkaline phosphatase (IAP) develop type 2 diabetes mellitus (T2DM). We hypothesized that a high level of IAP might be protective against T2DM in humans. We determined IAP levels in the stools of 202 diabetic patients and 445 healthy non-diabetic control people. We found ...
Kôji Watanabe, Carol A. Gilchrist, Md. Jashim Uddin, Stacey L. Burgess et al.
The disease severity of Entamoeba histolytica infection ranges from asymptomatic to life-threatening. Recent human and animal data implicate the gut microbiome as a modifier of E. histolytica virulence. Here we have explored the association of the microbiome with susceptibility to amebiasis in infan...
Shahinul Alam, Jhumur Ghosh, Golam Mustafa, Mohammad Amjad Kamal et al.
Background/purpose: Dipeptidyl peptidase 4 (DPP-4) expression is directly associated with hepatic lipogenesis and liver injury in nonalcoholic steatohepatitis (NASH). This study has been designed to elucidate the histological improvement of NASH with the DPP-4 inhibitor sitagliptin. Materials and me...
Abdullah Al Mamun, Suzia Aktar Suchi, Md. Abdul Aziz, Muhammad Zaeem et al.
Pyroptosis defines a new type of GSDMs-mediated programmed cell death, distinguishes from the classical concepts of apoptosis and necrosis-mediated cell death and is prescribed by cell swelling and membrane denaturation, leading to the extensive secretion of cellular components and low-grade inflamm...
David A. Sack, Sirajul Islam, Kenneth H. Brown, Asma Islam et al.
We performed a double-blind trial comparing sucrose electrolyte oral solution with glucose electrolyte oral solution in children less than 5 years of age with severe cholera-like diarrhea. Of 111 patients studied (102 with bacteriologically confirmed cholera), 55 received sucrose solution and 56 rec...
Md Borhanuddin, Md. Shamsuzzoha, Asif Hussain
So far known Andrographis paniculata Nees (AP) is a hepatoprotective, antiplatelet and antithrombotic drug. In this experiment its hypoglycaemic effect has been tried in various way. Water extract of AP 10 mg/kg body weight can prevent induction of hyperglycaemia significantly (P < 0.001) induced by...
Sohel Bin Azad, Prawej Ansari, Shofiul Azam, Saad Mosharraf Hossain et al.
Moringa oleifera has potential anti-hyperglycaemic effects that have been reported earlier by different scientific groups using animal models of diabetes. We aimed to explore the possible mechanisms of action of M. oleifera extract through different methods. Primarily, we measured fasting blood gluc...
Kristine M. Peterson, Xiaoti Guo, Abdel Elkahloun, Dinesh Mondal et al.
Entamoeba histolytica, a protozoan parasite, is an important cause of diarrhea and colitis in the developing world. Amebic colitis is characterized by ulceration of the intestinal mucosa. We performed microarray analysis of intestinal biopsies during acute and convalescent amebiasis in order to iden...