BACKGROUND: Vitamin-D deficiency and vitamin-D receptor genotype (VDR) are risk factors for several disorders with inflammatory components, including coronary heart disease (CHD) and diabetes, though the mechanisms involved are unclear. AIM: To examine the hypothesis that vitamin D status modulates ...
Zhengyuan Cheng, Manoj Hang Limbu, Zhi Wang, Jing Liu et al.
Gelatinases are members of the matrix metalloproteinase (MMPs) family; they play an important role in the degradation of the extracellular matrix (ECM). This effect is also crucial in the development and progression of chronic kidney disease (CKD). Its expression, as well as its activity regulation ...
Guy L. Reed, Gary R. Matsueda, Eldad Haber
Recent experiments in vitro have shown that inhibition of human alpha 2-antiplasmin by a monoclonal antibody (MAb RWR) markedly enhances clot lysis by plasminogen activators. To extend these studies in vivo, we tested whether inhibition of clot or fibrin-bound alpha 2-antiplasmin by MAb RWR could en...
Nicola Montgomery, A Hill, Suzanne McFarlane, Jessica Neisen et al.
INTRODUCTION: Basal-like breast cancers (BL-BCa) have the worst prognosis of all subgroups of this disease. Hyaluronan (HA) and the HA receptor CD44 have a long-standing association with cell invasion and metastasis of breast cancer. The purpose of this study was to establish the relation of CD44 to...
Chenbo Ding, Wendong Tang, Xiaobo Fan, Xiyong Wang et al.
Pseudopodium-enriched atypical kinase 1 (PEAK1), a novel non-receptor tyrosine kinase, has been demonstrated to act as an oncogenic regulator in breast and pancreatic cancers. However, the role of PEAK1 in the progression and metastasis of lung cancer is still unknown. Here, we observed that ectopic...
Joanna Fraczek, Tamara Vanhaecke, Vera Rogiers
INTRODUCTION: Vorinostat and romidepsin were the first histone deacetylase (HDAC) inhibitors (HDi) that fulfilled the preclinical promise of anticancer potential in clinical trials. Nevertheless, they merely opened a new chapter in the history of cancer therapy. Demonstration of their antitumor acti...
S. M. Zahid Hosen, Md. Nazim Uddin, Zhihong Xu, Benjamin J. Buckley et al.
Background Previous studies have revealed the role of dysregulated urokinase plasminogen activator (encoded by PLAU ) expression and activity in several pathways associated with cancer progression. However, systematic investigation into the association of PLAU expression with factors that modulate P...
R. B. Cole, N. C. Nevin, Gillian Blundell, J. D. Merrett et al.
Individuals with severe alpha-1-antitrypsin (alpha1AT) deficiency (phenotype Pi ZZ) are abnormally liable to develop emphysema, but it is uncertain whether those with partial alpha1AT deficiency (phenotypes Pi MS and MZ) are similarly susceptible. This study was undertaken to determine the frequency...
Rajnee Hasan, Md. Nazmul Haq Rony, Rasel Ahmed
BACKGROUND: The M4 family of metalloproteases is comprised of a large number of zinc-containing metalloproteases. A large number of these enzymes are important virulence factors of pathogenic bacteria and therefore potential drug targets. Whereas some enzymes have potential for biotechnological appl...
Satoshi Yoshino, Rebecca Cilluffo, Patricia J.M. Best, Elizabeth J. Atkinson et al.
BACKGROUND: Single nucleotide polymorphisms (SNPs) are the most common source of genetic variation. Although microvascular pathology is associated with cardiovascular events, genetic phenotypes causing microvascular disease remain largely unknown. This study identifies sex-specific SNPs associated w...
Anisul Haque Chowdhury, Akira Yokoyama, Yoshihiro Kokubo, Mohammad Mostafa Zaman et al.
The association between apolipoprotein E (apoE) genetic polymorphism and stroke has not been concordant in different racial populations. We investigated the association between apoE genotypes and stroke subtypes by a case-control study in Bangladesh for the first time among south Asian countries. Fi...
Ri-Zhen Huang, Gui-Bin Liang, Xiaochao Huang, Bin Zhang et al.
A series of dehydroabietic acid (DHAA) dipeptide derivatives containing the sulfonamide moiety were designed, synthesized and evaluated for inhibition of MMPs as well as the effects of in vitro cell migration. These compounds exhibited relatively good inhibition activity against MMPs with IC 50 valu...
Zannat Urbi, Nina Suhaity Azmi, Long Chiau Ming, Md. Sanower Hossain
Chondroitin sulphate (CS) is one of the most predominant glycosaminoglycans (GAGs) available in the extracellular matrix of tissues. It has many health benefits, including relief from osteoarthritis, antiviral properties, tissue engineering applications, and use in skin care, which have increased it...
John Gregson, Daniel F. Freitag, Praveen Surendran, Nathan O. Stitziel et al.
is unlikely to be a causal risk factor.
Chunxia Qin, Yangmeihui Song, Yongkang Gai, Weiwei Ruan et al.
Purpose Gallium-68-labeled fibroblast activation protein inhibitor ( 68 Ga-FAPI) is an emerging promising tumor tracer. This study aims to evaluate the diagnostic efficiency of 68 Ga-FAPI PET in gastrointestinal cancer, and to determine its potential impact on clinical management. Methods Patients w...