Daniel J. Klionsky, Amal Kamal Abdel‐Aziz, Sara Abdelfatah, Mahmoud Abdellatif et al.
autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
Emanuel Fleige, Mohiuddin Quadir, Rainer Haag
The use of polymeric nanocarriers to transport active compounds like small-molecular drugs, peptides, or genes found an increased attention throughout the different fields of natural sciences. Not only that these nanocarriers enhance the properties of already existing drugs in terms of solubility, b...
Talha Bin Emran, Asif Shahriar, Aar Rafi Mahmud, Tanjilur Rahman et al.
Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. ...
Rongrong Huang, Lei He, Yanyan Xia, Hongpan Xu et al.
Abstract Emerging evidence indicates that exosomes derived from gastric cancer cells enhance tumor migration and invasion through the modulation of the tumor microenvironment. However, it remains a major problem to detect cancer‐specific exosomes due to technical and biological challenges. Most of t...
Eunüs S. Ali, Shazid Md. Sharker, Muhammad Torequl Islam, Ishaq Khan et al.
Nanotechnology is reshaping health care strategies and is expected to exert a tremendous impact in the coming years offering better healthcare facilities. It has led to not only therapeutic drug delivery feasibility but also to diagnostics. Materials in the size of nano range (1-100 mm) used in the ...
Pooja Mittal, Anjali Saharan, Ravinder Verma, Farag M. A. Altalbawy et al.
Dendrimers are nanosized, symmetrical molecules in which a small atom or group of atoms is surrounded by the symmetric branches known as dendrons. The structure of dendrimers possesses the greatest impact on their physical and chemical properties. They grow outwards from the core-shell which further...
Muhammad Hammad Butt, Muhammad Zaman, Abrar Ahmad, Rahima Khan et al.
Over the past few decades, gene therapy has gained immense importance in medical research as a promising treatment strategy for diseases such as cancer, AIDS, Alzheimer's disease, and many genetic disorders. When a gene needs to be delivered to a target cell inside the human body, it has to pass a l...
Md Abdus Subhan, V. P. Torchilin
Nanocarriers as drug delivery systems are promising and becoming popular, especially for cancer treatment. In addition to improving the pharmacokinetics of poorly soluble hydrophobic drugs by solubilizing them in a hydrophobic core, nanocarriers allow cancer-specific combination drug deliveries by i...
Rongrong Huang, Lei He, Song Li, Hongna Liu et al.
exosomes per mL. Moreover, plasma from gastric cancer patients was tested to verify the clinical applicability of this assay. Our results demonstrated that this aptamer-based biosensor may show potential for the early diagnosis of gastric cancer.
Amit Biswas, Md. Reazul Islam, Zahid Sadek Choudhury, Asif Mostafa et al.
The current decades are marked not by the development of new molecules for the cure of various diseases but rather the development of new delivery methods for optimum treatment outcome. Nanomedicine is perhaps playing the biggest role in this concern. Nanomedicine offers numerous advantages over con...
Md Abdus Subhan, Torchilin Vp
Gene silencing by RNA interference represents a promising therapeutic approach. The development of carriers, e.g., polymers, lipids, peptides, antibodies, aptamers, small molecules, exosome and red blood cells is crucial for the systemic delivery of siRNA. Cell-specific targeting ligands in the nano...
Saikat Kumar Poddar, Ali Ehsan Sifat, Sanjana Haque, Noor Ahmed Nahid et al.
Nicotinamide mononucleotide (NMN) is a nucleotide that is most recognized for its role as an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis. Although the biosynthetic pathway of NMN varies between eukaryote and prokaryote, two pathways are mainly followed in case of eukaryotic...
Michael Lim, Abu Zayed Md Badruddoza, Jannatul Firdous, Mohammad Azad et al.
DNA vaccines offer a flexible and versatile platform to treat innumerable diseases due to the ease of manipulating vaccine targets simply by altering the gene sequences encoded in the plasmid DNA delivered. The DNA vaccines elicit potent humoral and cell-mediated responses and provide a promising me...
Shayna Sharma, Mostafa Kamal Masud, Yusuf Valentino Kaneti, Prarthana Rewatkar et al.
Extracellular vesicles (EVs) can transfer intercellular messages in various (patho)physiological processes and transport biomolecules to recipient cells. EVs possess the capacity to evade the immune system and remain stable over long periods, identifying them as natural carriers for drugs and biolog...
Md. Matiur Rahman, Kaori Shimizu, Marika Yamauchi, Hiroshi Takase et al.
Bovine milk extracellular vesicles (EVs) attract research interest as carriers of biologically active cargo including miRNA from donor to recipient cells to facilitate intercellular communication. Since toxicity of edible milk seems to be negligible, milk EVs are applicable to use for therapeutics i...