Shoumen Lasker, Md Mizanur Rahman, Faisal Parvez, Mushfera Zamila et al.
The main objective of this experiment was to determine the effects of yogurt supplementation on fat deposition, oxidative stress, inflammation and fibrosis in the liver of rats with high-fat (HF) diet-induced obesity. Male Wistar rats were used in this study and were separated into the following fou...
Tetsuya Shiuchi, Mohammad Shahidul Haque, Shiki Okamoto, Tsuyoshi Inoue et al.
Hypothalamic neurons containing orexin (hypocretin) are activated during motivated behaviors and active waking. We show that injection of orexin-A into the ventromedial hypothalamus (VMH) of mice or rats increased glucose uptake and promoted insulin-induced glucose uptake and glycogen synthesis in s...
Priya Duggal, Xiaoti Guo, Rashidul Haque, Kristine M. Peterson et al.
Malnutrition substantially increases susceptibility to Entamoeba histolytica in children. Leptin is a hormone produced by adipocytes that inhibits food intake, influences the immune system, and is suppressed in malnourished children. Therefore we hypothesized that diminished leptin function may incr...
Hong Zhuang, Xiuting Yao, Hong Li, Qian Li et al.
High-fat diet (HFD) consumption is generally associated with an increased risk of cognitive and emotional dysfunctions that constitute a sizeable worldwide health burden with profound social and economic consequences. Middle age is a critical time period that affects one's health later in life; pert...
B. D. Green, Nigel Irwin, Peter R. Flatt
Obestatin is a recently discovered peptide hormone that appears to be involved in reducing food intake, gut motility and body weight. Obestatin is a product of the preproghrelin gene and appears to oppose several physiological actions of ghrelin. This study investigated the acute effects of obestati...
Bronwen Martin, Rakel López de Maturana, Randall Brenneman, Tom Walent et al.
G protein-coupled receptors (GPCRs) play pivotal roles in regulating the function and plasticity of neuronal circuits in the nervous system. Among the myriad of GPCRs expressed in neural cells, class II GPCRs which couples predominantly to the Gs-adenylate cyclase-cAMP signaling pathway, have recent...
Mahmuda Begum, Mayank Choubey, Munichandra Babu Tirumalasetty, Shahida Arbee et al.
Diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia, presents a formidable global health challenge with its associated complications. Adiponectin, an adipocyte-derived hormone, has emerged as a significant player in glucose metabolism and insulin sensitivity. Beyond its me...
Changqing Zhao, Da Liu, Hai Li, Lei‐Sheng Jiang et al.
STUDY DESIGN: Human herniated disc tissues and rat nucleus pulposus (NP) cells were used following approval by the authors' institutional Human Ethics Review Committee and Animal Care and Use Committee. OBJECTIVE: To determine the expression of leptin and its functional receptor in herniated disc ti...
Joanne Harrison, David W. Miller, Patricia A. Findlay, Clare L. Adam
Ghrelin is a circulating peptide, primarily secreted by the gut, that has reported actions within the hypothalamo-pituitary axis to stimulate food intake, inhibit GnRH/LH secretion and stimulate GH secretion in monogastric species. Here, we examine responses to centrally administered ghrelin in a se...
Md. Nazmul Haque, Md. Abdul Hannan, Raju Dash, Sung Min Choi et al.
BACKGROUND Neuronal excitotoxicity induces a plethora of downstream signaling pathways, resulting in the calcium overload-induced excitotoxic cell death, a well-known phenomenon in cerebrovascular and neurodegenerative disorders. The naturally occurring phytosterol, stigmasterol (ST) is known for it...
Parul Christian, Jee Hyun Rah, Abu Ahmed Shamim, Ummeh T. Arju et al.
Menarche is an important milestone in the development of female adolescents. The study assessed the age at menarche using recall, its seasonality, and association with marital and nutritional status (using midupper arm circumference [MUAC]) among 3,923 female adolescents aged 12–19 years in a rural ...
Shams Kursan, Timothy S. McMillen, Pavani Beesetty, Eduardo Dias-Junior et al.
Abstract Intracellular chloride concentration ([Cl − ] i ) in pancreatic β-cells is kept above electrochemical equilibrium due to the predominant functional presence of Cl − loaders such as the Na + K + 2Cl − co-transporter 1 ( Slc12a2 ) over Cl − extruders of unidentified nature. Using molecular cl...
Weijie Wu, Wenhai Sui, Sizhe Chen, Ziheng Guo et al.
mice exacerbated atherosclerosis. Whole-genome expression profiling discovered that CX3CL1 chemokine was the most upregulated gene in the insulin-stimulated arterial endothelial cells. Specific deletion of a CX3CL1 receptor, Cx3cr1 gene, in monocytes/macrophages completely abrogated the APM-exacerba...
Md Azharul Hoque, Kazuo Katoh, Keiichi Suzuki
Genetic relationships of measures of residual feed intake and daily feed intake with serum IGF-I concentrations at 8 wk of age and at 105 kg of BW, serum leptin concentration at 105 kg of BW, meat quality, and different fat accumulation traits on 834 Duroc pigs in 7 generations were estimated. Two m...
Chayon Goswami, Katsuya Dezaki, Lei Wang, Akio Inui et al.
Reduced appetite or anorexia substantially deteriorates quality of life in various diseases including cancer, depression and heart failure. Furthermore, reduced appetite may stand upstream of sarcopenia and frailty. All these diseases are heavy burdens in the modern medicine and society. Therefore, ...