Journal ArticleOpen Access
Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation
Authors
Author Affiliations
Chinese Academy of Medical Sciences & Peking Union Medical College, Shandong Academy of Chinese Medicine, Sichuan University, West China Hospital of Sichuan University, ...
Published InCell Metabolism
Year2025
Citations46
Abstract
mice exacerbated atherosclerosis. Whole-genome expression profiling discovered that CX3CL1 chemokine was the most upregulated gene in the insulin-stimulated arterial endothelial cells. Specific deletion of a CX3CL1 receptor, Cx3cr1 gene, in monocytes/macrophages completely abrogated the APM-exacerbated atherosclerosis. Our findings uncover a novel mechanism of APM-associated atherosclerosis and therapeutic targeting of the endothelial CX3CL1-macrophage CX3CR1 signaling axis provides an approach for treating atherosclerotic CVD.
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