Ana Navas‐Acién, Ellen K. Silbergeld, Robin A. Streeter, Jeanne M. Clark et al.
Chronic arsenic exposure has been suggested to contribute to diabetes development. We performed a systematic review of the experimental and epidemiologic evidence on the association of arsenic and type 2 diabetes. We identified 19 in vitro studies of arsenic and glucose metabolism. Five studies repo...
Katherine Moon, Shilpi Oberoi, Aaron Barchowsky, Yu Chen et al.
Background: Consistent evidence at high levels of water arsenic (≥100 µg/l), and growing evidence at low-moderate levels (<100 µg/l), support a link with cardiovascular disease (CVD). The shape of the dose-response across low-moderate and high levels of arsenic in drinking water is uncertain and cri...
Rick J. Jansen, Maria Argos, Tong Lin, Jiabei Li et al.
BACKGROUND: Exposure to inorganic arsenic (iAs), a class I carcinogen, affects several hundred million people worldwide. Once absorbed, iAs is converted to monomethylated (MMA) and then dimethylated forms (DMA), with methylation facilitating urinary excretion. The abundance of each species in urine ...
Chun Fa Huang, Ya Wen Chen, Ching‐Yao Yang, Keh‐Sung Tsai et al.
Arsenic is a naturally occurring toxic metalloid of global concern. Many studies have indicated a dose-response relationship between accumulative arsenic exposure and the prevalence of diabetes mellitus (DM) in arseniasis-endemic areas in Taiwan and Bangladesh, where arsenic exposure occurs through ...
Christopher D. Heaney, Brittany Kmush, Ana Navas‐Acién, Kevin A. Francesconi et al.
Background Arsenic has immunomodulatory properties and may have the potential to alter susceptibility to infection in humans. Objectives We aimed to assess the relation of arsenic exposure during pregnancy with immune function and hepatitis E virus (HEV) infection, defined as seroconversion during p...
Roheeni Saxena, Mary V. Gamble, Gail A. Wasserman, Xinhua Liu et al.
BACKGROUND: Over 57 million people in Bangladesh have been chronically exposed to arsenic-contaminated drinking water. They also face environmental exposure to elevated levels of cadmium (Cd), manganese (Mn), and lead (Pb), all of which have been previously observed in environmental and biological s...
Ahlam Abuawad, Miranda J. Spratlen, Faruque Parvez, Vesna Slavkovich et al.
BACKGROUND: Water-borne arsenic (As) exposure is a global health problem. Once ingested, inorganic As (iAs) is methylated to mono-methyl (MMA) and dimethyl (DMA) arsenicals via one-carbon metabolism (OCM). People with higher relative percentage of MMA (MMA%) in urine (inefficient As methylation), ha...
Megan M. Niedzwiecki, Xinhua Liu, Huiping Zhu, Megan N. Hall et al.
Background Inorganic arsenic (As) is methylated via one carbon metabolism (OCM) to mono- and dimethylated arsenicals (MMA and DMA), facilitating urinary excretion. Hyperhomocysteinemia (HHcys), a marker of impaired OCM, is a risk factor for As-induced skin lesions, but the influences of single nucle...
Tiffany R. Sanchez, Vesna Slavkovich, Nancy J. LoIacono, Alexander van Geen et al.
INTRODUCTION: Environmental exposure to toxic metals and metalloids is pervasive and occurs from multiple sources. The Health Effects of Arsenic Longitudinal Study (HEALS) is an ongoing prospective study predominantly focused on understanding health effects associated with arsenic exposure from drin...
Anne K. Bozack, Philippe Boileau, Linqing Wei, Alan Hubbard et al.
BACKGROUND: Arsenic (As) exposure through drinking water is a global public health concern. Epigenetic dysregulation including changes in DNA methylation (DNAm), may be involved in arsenic toxicity. Epigenome-wide association studies (EWAS) of arsenic exposure have been restricted to single populati...
Linden Huhmann, Charles F. Harvey, Ana Navas‐Acién, Joseph H. Graziano et al.
BACKGROUND: Concentrations of arsenic (As) are elevated in a large proportion of wells in Bangladesh but are spatially variable even within a village. This heterogeneity can enable exposed households to switch to a nearby well lower in As in response to blanket (area-wide) well As testing. OBJECTIVE...
Ahlam Abuawad, Jeff Goldsmith, Julie B. Herbstman, Faruque Parvez et al.
Urinary As (uAs) is a biomarker of As exposure. Urinary creatinine (uCr) or specific gravity (SG) are used to correct uAs for urine dilution. However, uCr is correlated with As methylation, whereas SG has limitations in individuals with kidney damage. We aimed to evaluate which urine dilution correc...
George Adamson, David A. Polya
It has been increasingly recognised that calculation of the disease burden due to populations, such as in Bangladesh, extensively using hazardous arsenic bearing well waters, must explicitly account for the trade-off between diarrhoeal disease incidence and that of arsenic-related diseases. This is ...
Ahlam Abuawad, Anne K. Bozack, Ana Navas‐Acién, Jeff Goldsmith et al.
Background: Chronic arsenic (As) exposure is a global environmental health issue. Inorganic As (InAs) undergoes methylation to monomethyl (MMAs) and dimethyl-arsenical species (DMAs); full methylation to DMAs facilitates urinary excretion and is associated with reduced risk for As-related health out...
Haotian Wu, Vrinda Kalia, Megan M. Niedzwiecki, Marianthi‐Anna Kioumourtzoglou et al.
Chronic exposure to arsenic (As) remains a global public health concern and our understanding of the biological mechanisms underlying the adverse effects of As exposure remains incomplete. Here, we used a high-resolution metabolomics approach to examine how As affects metabolic pathways in humans. W...