Mahmud Tareq Hassan Khan, Arjumand Ather, Kenneth D. Thompson, Roberto Gambari
Herpes simplex viruses (HSV-1 and -2) are important pathogens for humans, especially in the case of highly susceptible adults. Moreover, HSV-2 has been reported to be a high risk factor for HIV infection. Therefore, the discovery of novel anti-HSV drugs deserves great efforts. In this paper, we revi...
Letícia V. Costa‐Lotufo, Mahmud Tareq Hassan Khan, Arjumand Ather, Diego Veras Wilke et al.
The present study evaluated the anticancer potential of 11 plants used in Bangladeshi folk medicine. The extracts were tested for cytotoxicity using the brine shrimp lethality assay, sea urchin eggs assay, hemolysis assay and MTT assay using tumor cell lines. The extract of Oroxylum indicum showed t...
Mahmud Tareq Hassan Khan, M. Iqbal Choudhary, Khalid Mohammed Khan, Mubeen Rani et al.
Here the tyrosinase inhibition studies of library of 2,5-disubstituted-1,3,4-oxadiazoles have been reported and their structure-activity relationship (SAR) also have been discussed. The library of the oxadiazoles was synthesized under the microwave irradiation and was structures of these were charac...
Mahmud Tareq Hassan Khan
Abstract The enzyme tyrosinase is known to be a multifunctional copper-containing enzyme from the oxidase superfamily, which is the key protein involved in the biosynthesis of the large biological pigment, melanin. The enzyme catalyzes two distinct reactions of melanin biosynthesis, the hydroxylatio...
Elisabetta Lambertini, Roberta Piva, Mahmud Tareq Hassan Khan, Ilaria Lampronti et al.
In this study we determined the activity of extracts from Bangladeshi medicinal plants (Emblica officinalis, Aegle marmelos, Vernonia anthelmintica, Oroxylum indicum, Argemone mexicana) on human breast tumor cell lines. Extracts from E. officinalis and O. indicum displayed anti-proliferative activit...
Gerardo M. Casañola‐Martín, Yovani Marrero‐Ponce, Mahmud Tareq Hassan Khan, Arjumand Ather et al.
A new set of bond-level molecular descriptors (bond-based linear indices) are used here in QSAR (quantitative structure-activity relationship) studies of tyrosinase inhibitors, for finding functions that discriminate between the tyrosinase inhibitor compounds and inactive ones. A database of 246 com...
Mahmud Tareq Hassan Khan, Sher Bahadar Khan, Arjumand Ather
New tyrosinase inhibitory cycloartane triterpenoids have been discovered from the methanol extract of the whole plant of Amberboa ramosa (Roxb.) Jafri, which is a member from the Compositae family. Utilizing the conventional spectroscopic techniques, including 1D and 2D NMR analysis, and also by com...
Gerardo M. Casañola‐Martín, Mahmud Tareq Hassan Khan, Yovani Marrero‐Ponce, Arjumand Ather et al.
In the present report, the use of the atom-based linear indices for finding functions that discriminate between the tyrosinase inhibitor compounds and inactive ones is presented. In this sense, discriminant models were applied and globally good classifications of 93.51% and 92.46% were observed for ...
Gerardo M. Casañola‐Martín, Yovani Marrero‐Ponce, Mahmud Tareq Hassan Khan, Arjumand Ather et al.
QSAR (quantitative structure-activity relationship) studies of tyrosinase inhibitors employing Dragon descriptors and linear discriminant analysis (LDA) are presented here. A data set of 653 compounds, 245 with tyrosinase inhibitory activity and 408 having other clinical uses were used. The active d...
Yovani Marrero‐Ponce, Mahmud Tareq Hassan Khan, Gerardo M. Casañola‐Martín, Arjumand Ather et al.
A set of novel atom-based molecular fingerprints is proposed based on a bilinear map similar to that defined in linear algebra. These molecular descriptors (MDs) are proposed as a new means of molecular parametrization easily calculated from 2D molecular information. The nonstochastic and stochastic...
Ilaria Lampronti, Mahmud Tareq Hassan Khan, Monica Borgatti, Nicoletta Bianchi et al.
Several transcription factors (TFs) play crucial roles in governing the expression of different genes involved in the immune response, embryo or cell lineage development, cell apoptosis, cell cycle progression, oncogenesis, repair and fibrosis processes and inflammation. As far as inflammation, TFs ...
Elizabeth Lambertini, Ilaria Lampronti, Letizia Penolazzi, Mahmud Tareq Hassan Khan et al.
The aim of the present study was to determine whether the expression of the estrogen receptor alpha (ERalpha) gene may be a possible target for compounds present in plant extracts from Aegle marmelos and Emblica officinalis, used in traditional Asian medicine in the treatment of tissue inflammation ...
Mahmud Tareq Hassan Khan, M. Iqbal Choudhary, Atta‐ur Rahman, R. P. Mamedova et al.
In the present paper, tyrosinase inhibition studies and structure-activity relationship of eight cycloartane glycosides and one cucurbitane glycoside and its genin, which were isolated from Astragalus (Leguminoseae) and Bryonia (Cucurbitaceae) plants, have been discussed. The activities are compared...
Gerardo M. Casañola‐Martín, Yovani Marrero‐Ponce, Mahmud Tareq Hassan Khan, Francisco Torrens et al.
Two-dimensional atom- and bond-based TOMOCOMD-CARDD descriptors and linear discriminant analysis (LDA) are used in this report to perform a quantitative structure-activity relationship (QSAR) study of tyrosinase-inhibitory activity. A database of inhibitors of the enzyme is collected for this study,...
Mahmud Tareq Hassan Khan, Arjumand Ather
Identification of phenolic compounds and their derivatives interfering the several steps of the viral life cycle of the human immunodeficiency virus type 1 (HIV-1) is focused for the development of novel molecules for the treatment of AIDS. Several phenolic compounds isolated and characterized from ...
Yovani Marrero‐Ponce, Mahmud Tareq Hassan Khan, Gerardo M. Casañola‐Martín, Arjumand Ather et al.
In this paper, we present a new set of bond-level TOMOCOMD-CARDD molecular descriptors (MDs), the bond-based bilinear indices, based on a bilinear map similar to those defined in linear algebra. These novel MDs are used here in Quantitative Structure-Activity Relationship (QSAR) studies of tyrosinas...
Tareq Mahmud, Mohammad Mahmudul Hassan, Mahabub Alam, Md Mamun Khan et al.
Salmonellosis is one of the most common and widely distributed foodborne illnesses in human, and multidrugresistance of Salmonella spp. has increased in developing countries with the indiscriminate use of antibiotics in the poultry production system. A cross-sectional study was conducted on randomly...
Md. Shafi-Ul- Alam, Tareq Mahmud, Shahneaz Ali Khan, Ariful Islam et al.
© 2018 Network for the Veterinarians of Bangladesh. Objective: A significant number of animals enrolled at UVH regularly from surrounding villages for treating their sick animals, de-worming, vaccination purposes. Therefore, a study was done to define the occurrence of common diseases and disease co...
Mahmud Tareq Hassan Khan
Yovani Marrero Ponce, Mahmud Tareq Hassan Khan, Gerardo M. Casañola‐Martín, Arjumand Ather et al.
Abstract Herein we present results of QSAR studies of tyrosinase inhibitors employing one of the atom‐based TOMOCOMD‐CARDD (acronym of TOpological MOlecular COMputer Design‐Computer Aided “Rational” Drug Design) descriptors, molecular quadratic indices , and Linear Discriminant Analysis (LDA) as pat...