Mohammad H. Forouzanfar, Ashkan Afshin, Lily Alexander, H Ross Anderson et al.
BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debat...
Elizabeth A. Ashley, Mehul Dhorda, Rick M. Fairhurst, Chanaki Amaratunga et al.
BACKGROUND: Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistance is essential for planning containment and elimination strategies. METHODS: Between May 2011 and Apri...
Sofie Vermeiren, Roberta Vella-Azzopardi, David Beckwée, Ann-Katrin Habbig et al.
Introduction Frailty is one of the most important concerns regarding our aging population. Evidence grows that the syndrome is linked to several important health outcomes. A general overview of frailty concepts and a comprehensive meta-analysis of their relation with negative health outcomes still l...
Monika Böhm, Ben Collen, Jonathan Baillie, Philip Bowles et al.
Effective and targeted conservation action requires detailed information about species, their distribution, systematics and ecology as well as the distribution of threat processes which affect them. Knowledge of reptilian diversity remains surprisingly disparate, and innovative means of gaining rapi...
Christopher J L Murray, Cristiana Abbafati, Kaja Abbas, Mohammad Hossein Abbasi et al.
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first ...
Olivo Miotto, Roberto Amato, Elizabeth A. Ashley, Bronwyn MacInnis et al.
We report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domains, ...
Ibrahim A Khalil, Christopher Troeger, Puja C Rao, Brigette F. Blacker et al.
BACKGROUND: The protozoan Cryptosporidium is a leading cause of diarrhoea morbidity and mortality in children younger than 5 years. However, the true global burden of Cryptosporidium infection in children younger than 5 years might have been underestimated in previous quantifications because it only...
Christine Jost, Florence Birungi Kyazze, Jesse B. Naab, Sharmind Neelormi et al.
In Uganda, Ghana and Bangladesh, participatory tools were used for a socio-economic and gender analysis of three topics: climate-smart agriculture (CSA), climate analogue approaches, and climate and weather forecasting. Policy and programme-relevant results were obtained. Smallholders are changing a...
Robert Dreibelbis, Peter J. Winch, Elli Leontsini, Kristyna R. S. Hulland et al.
BACKGROUND: Promotion and provision of low-cost technologies that enable improved water, sanitation, and hygiene (WASH) practices are seen as viable solutions for reducing high rates of morbidity and mortality due to enteric illnesses in low-income countries. A number of theoretical models, explanat...
James A Platts-Mills, Jie Liu, Elizabeth T. Rogawski McQuade, Furqan Kabir et al.
BACKGROUND: Optimum management of childhood diarrhoea in low-resource settings has been hampered by insufficient data on aetiology, burden, and associated clinical characteristics. We used quantitative diagnostic methods to reassess and refine estimates of diarrhoea aetiology from the Etiology, Risk...
Elizabeth T. Rogawski McQuade, Jie Liu, James A Platts-Mills, Furqan Kabir et al.
BACKGROUND: Enteropathogen infections in early childhood not only cause diarrhoea but contribute to poor growth. We used molecular diagnostics to assess whether particular enteropathogens were associated with linear growth across seven low-resource settings. METHODS: We used quantitative PCR to dete...
Kathryn E. Lafond, Harish Nair, Mohammad Hafiz Rasooly, Fátima Valente et al.
BACKGROUND: The global burden of pediatric severe respiratory illness is substantial, and influenza viruses contribute to this burden. Systematic surveillance and testing for influenza among hospitalized children has expanded globally over the past decade. However, only a fraction of the data has be...
Robert W Aldridge, Dan Lewer, Srinivasa Vittal Katikireddi, Rohini Mathur et al.
<ns4:p> <ns4:bold>Background</ns4:bold> : International and UK data suggest that Black, Asian and Minority Ethnic (BAME) groups are at increased risk of infection and death from COVID-19. We aimed to explore the risk of death in minority ethnic groups in England using data reported by NHS England. <...
Ana Maria B. Menezes, María Montes de, Rogelio Pérez‐Padilla, Gilbert Nadeau et al.
Background Several COPD phenotypes have been described; the COPD-asthma overlap is one of the most recognized. The aim of this study was to evaluate the prevalence of three subgroups (asthma, COPD, and COPD-asthma overlap) in the Latin American Project for the Investigation of Obstructive Lung Disea...
Frederick Koster, Jack Levin, L Walker, Kenneth S. K. Tung et al.
To investigate three possible causes of the acute hemolysis in the hemolytic-uremic syndrome, we studied prospectively 207 children and 34 adults with shigellosis in Bangladesh. Nineteen children showed acute hemolytic anemia, a leukemoid reaction, thrombocytopenia and oliguria; nine other had, in a...
Robert Y. Chen, Ishita Mostafa, Matthew C. Hibberd, Subhasish Das et al.
BACKGROUND: More than 30 million children worldwide have moderate acute malnutrition. Current treatments have limited effectiveness, and much remains unknown about the pathogenesis of this condition. Children with moderate acute malnutrition have perturbed development of their gut microbiota. METHOD...
Jennifer Bryce, César G. Victora, Jean‐Pierre Habicht, Robert E. Black et al.
OBJECTIVE: To summarize the expectations held by World Health Organization programme personnel about how the introduction of the Integrated Management of Childhood Illness (IMCI) strategy would lead to improvements in child health and nutrition, to compare these expectations with what was learned fr...
Rosália Maria Tôrres de Lima, Antonielly Campinho dos Reis, Ag‐Anne Pereira Melo de Menezes, José Victor de Oliveira Santos et al.
Natural dietary agents have attracted considerable attention due to their role in promoting health and reducing the risk of diseases including cancer. Ginger, one of the most ancient known spices, contains bioactive compounds with several health benefits. [6]-Gingerol constitutes the most pharmacolo...
Hakan Erdem, Daniel R. Lucey
•Healthcare workers (HCW) are part of the frontline in the struggle against the pandemic.•Many HCWs have been infected with SARS-CoV-2 and have ldied worldwide during the pandemic.•We performed an international survey and requested the total numbers of HCW deaths and infections.•Data were obtained f...
Jean‐Marc Mac‐Thiong, Ensor E. Transfeldt, Amir A. Mehbod, Joseph H. Perra et al.
STUDY DESIGN: This study prospectively evaluated the health related quality of life (HRQOL) of 73 adults presenting with scoliosis at a single institution, as related to their spinal (C7 plumbline) and global (gravity line) balance. OBJECTIVE: To assess the influence of sagittal and coronal balance ...