Christopher G. Jacob, Thuy-Nhien Nguyen, Mayfong Mayxay, Richard J. Maude et al.
Background: National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integ...
Rapeephan R. Maude, Md. Amir Hossain, Mahtab Uddin Hassan, Sophie Osbourne et al.
INTRODUCTION: Measurement of optic nerve sheath diameter (ONSD) by ultrasound is increasingly used as a marker to detect raised intracranial pressure (ICP). ONSD varies with age and there is no clear consensus between studies for an upper limit of normal. Knowledge of normal ONSD in a healthy popula...
Ricardo Ataíde, Elizabeth A. Ashley, Rosanna Powell, Jo-Anne Chan et al.
Significance Slow-clearing artemisinin-resistant malaria parasites are now well established in the Greater Mekong Subregion. This large multinational therapy efficacy study incorporating clinical data, molecular drug-resistance markers, and immune profiling aimed to understand how variations in popu...
Katherine Plewes, Hugh W. F. Kingston, Aniruddha Ghose, Richard J. Maude et al.
Intravascular hemolysis is an intrinsic feature of severe malaria pathophysiology but the pathogenic role of cell-free hemoglobin-mediated oxidative stress in severe malaria associated acute kidney injury (AKI) is unknown. As part of a prospective observational study, enrolment plasma cell-free hemo...
Arjen M. Dondorp, Shivakumar Iyer, Marcus J. Schultz
In many low-and middle-income countries, with improved public health services like sanitation and immunization, the relative contribution of curative care for critically ill patients to overall health and life expectancy has increased considerably.The importance of intensive care facilities as a glo...
Amol C. Shetty, Christopher G. Jacob, Fang Huang, Yao Li et al.
Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms call...
Josh Hanson, Sophia WK Lam, Sanjib Mohanty, Shamshul Alam et al.
OBJECTIVE: To evaluate the efficacy and safety of liberal fluid resuscitation of adults with severe malaria. DESIGN, SETTING, PATIENTS, AND METHODS: Twenty-eight Bangladeshi and Indian adults with severe falciparum malaria received crystalloid resuscitation guided by transpulmonary thermodilution (P...
Josh Hanson, Sue J. Lee, Md Amir Hossain, Nicholas M. Anstey et al.
BACKGROUND: Microvascular obstruction and endothelial dysfunction have both been linked to tissue hypoperfusion in falciparum malaria, but their relative contributions to the disease's pathogenesis and outcome are unknown. METHODS: Microvascular blood flow was quantified in adults with severe falcip...
Rashan Haniffa, Mavuto Mukaka, Sithum Munasinghe, Ambepitiyawaduge Pubudu De Silva et al.
BACKGROUND: Current critical care prognostic models are predominantly developed in high-income countries (HICs) and may not be feasible in intensive care units (ICUs) in lower- and middle-income countries (LMICs). Existing prognostic models cannot be applied without validation in LMICs as the differ...
Richard J. Maude, Nicholas A. V. Beare, Abdullah Abu Sayeed, Christina C. Chang et al.
A specific retinopathy has been described in African children with cerebral malaria, but in adults this has not been extensively studied. Since the structure and function of the retinal vasculature greatly resembles the cerebral vasculature, study of retinal changes can reveal insights into the path...
Lei Zhu, Jaishree Tripathi, Frances Rocamora, Olivo Miotto et al.
The predisposition of parasites acquiring artemisinin resistance still remains unclear beyond the mutations in Pfk13 gene and modulation of the unfolded protein response pathway. To explore the chain of casualty underlying artemisinin resistance, we reanalyze 773 P. falciparum isolates from TRACI-st...
Papa Alioune Ndour, Sébastien Larréché, Oussama Mouri, Nicolas Argy et al.
persists in the circulation of artesunate-treated malaria patients in Bangladesh and in French travelers who became infected with malaria in Africa. HRP2 persisted in whole blood (not plasma) of artesunate-treated patients with malaria at higher levels compared to quinine-treated patients. Using an ...
Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak et al.
The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P....
Weijian Ye, Marvin Chew, Jue Hou, Fritz Lai et al.
Natural killer (NK) cells provide the first line of defense against malaria parasite infection. However, the molecular mechanisms through which NK cells are activated by parasites are largely unknown, so is the molecular basis underlying the variation in NK cell responses to malaria infection in the...
Liesbeth M. Kager, Dana C. Blok, Ivar O Lede, Wahid Rahman et al.
Objectives Human tuberculosis (TB) remains an important cause of death globally. Bangladesh is one of the most affected countries. We aimed to investigate the impact of pulmonary TB on pro- and anticoagulant mechanisms. Methods This prospective study was conducted in Chittagong, Bangladesh. We perfo...