Anthony De Soyza, T. F. Saunders, Georgina Wild, Phil Mawson et al.
Background Bronchiectasis is associated with psychological comorbidity and poor quality of life (QoL), yet guidelines lack focus on psychological morbidity. Using data obtained from the BronchUK database (1341 patients), we examined the link between anxiety/depression and physical disease severity, ...
Yuki Kakinuma, Colin E. Goldsmith, A. Watt, J.S. Elborn et al.
"Molecular conservation within LES9F and PS21 Liverpool epidemic strain (LES) markers in wild-type clinical Pseudomonas aeruginosa isolated from the sputum of adult patients with cystic fibrosis." British Journal of Biomedical Science, 67(2), pp. 87–88
R.A. Brown, Small Dm, AA Abladey, LJ Holsinger et al.
Introduction: Elevated levels of the cysteine protease cathepsin S (cat S) are found in Cystic fibrosis (CF) lung secretions, however, the role of cat S in CF lung disease is unclear. Cat S is capable of maintaining its activity at a neutral pH allowing it to remain active outside of the cell. Conse...
Michal Shteinberg, Joseph Rivlin, Michal Gur, Muriel Konopnicki et al.
Haptoglobin (Hp), a heme-Iron chelator, has different isoforms which are associated with variable tendency toward infections: Hp 1-1, Hp 2-1, and Hp 2-2. Cystic fibrosis (CF) outcomes are variable and influenced by genetic and environmental factors. The aim of this study was to determine whether Hp ...
David Comer, J.S. Elborn, Vanessa Brown, Colleen M. McDowell et al.
Although cigarette smoke extract (CSE) is widely used in respiratory research, the methods used in its preparation are diverse and there is no consensus as to whether cigarette smoke extract (CSE) induces a pro-inflammatory or an immunosuppressive response in epithelial cells.1 Although the adverse ...
Henil Upadhyay, Anthony De Soyza, Rosie Watson, Phil Mawson et al.
<h3>Introduction</h3> BRONCHUK is a multicentre, prospective, observational cohort study enrolling adults with radiologically confirmed bronchiectasis across secondary centres in the UK. The objectives of the study are to develop a multicentre bronchiectasis registry incorporating baseline data coll...
Anthony De Soyza, Rebecca Watson, Phil Mawson, Tom Shield et al.
<bold>Introduction:</bold> Multimorbidity(MM) is associated with poor outcomes in the general population.The BACI index in bronchiectasis confirms certain comorbidities are adversely prognostic.We aimed to assess the prevalence,and association of MM with outcomes of death and hospitalisation. <bold>...
Zina Alfahl, G.G. Einarsson, J.S. Elborn, D.F. Gilpin et al.
Judy Bradley, Rohan Anand, Brenda O’Neill, Kathryn M. Ferguson et al.
Abstract Background: Current guidelines for the management of bronchiectasis (BE) highlight the lack of evidence to recommend mucoactive agents, such as hypertonic saline (HTS) and carbocisteine, to aid sputum-removal as part of standard care. We hypothesise that mucoactive agents (HTS or cabocistei...
Judy Bradley, Rohan Anand, Brenda O’Neill, Kathryn M. Ferguson et al.
Abstract Background Current guidelines for the management of bronchiectasis (BE) highlight the lack of evidence to recommend mucoactive agents, such as hypertonic saline (HTS) and carbocisteine, to aid sputum-removal as part of standard care. We hypothesise that mucoactive agents (HTS or cabocistein...
Ryan Brown, Donna M. Small, Anthony Abladey, Leslie J. Holsinger et al.
Elevated levels of the cysteine protease cathepsin S (cat S) are found in cystic fibrosis (CF) lung secretions, however, the role of cat S in CF lung disease is unclear. Cat S is capable of maintaining its activity at a neutral pH allowing it to remain active outside of the cell. Consequently, cat S...
N. Magee, Robert D. Gray, M. Imrie, Ray W. Shepherd et al.
Kathy McClean, Chris R. Cardwell, Frank Kee, Ian Young et al.