Hao-Wei Chang, Evan M. Lee, William Yi Wang, Cyrus Zhou et al.
Preclinical and clinical studies are providing evidence that the healthy growth of infants and children reflects, in part, healthy development of their gut microbiomes 1–5 . This process of microbial community assembly and functional maturation is perturbed in children with acute malnutrition. Gnoto...
Aleksandr A. Arzamasov, Dmitry A. Rodionov, Matthew Charles Hibberd, Janaki L. Guruge et al.
Bifidobacteria are among the earliest colonizers of the human gut and are widely used as probiotics for their health-promoting properties. However, individual responses to probiotic supplementation may vary with strain type(s), microbiota composition, diet, or lifestyle conditions, highlighting the ...
Steven J. Hartman, Matthew C. Hibberd, Ishita Mostafa, Naila Nurun Nahar et al.
Severe acute malnutrition (SAM), defined anthropometrically as a weight-for-length z-score more than 3 standard deviations below the mean (WLZ<-3), affects 19 million children under 5-years-old worldwide. Complete anthropometric recovery after standard inventions is rare with children often left wit...
Matthew C. Hibberd, Daniel M. Webber, Dmitry A. Rodionov, Suzanne Henrissat et al.
Evidence is accumulating that perturbed postnatal development of the gut microbiome contributes to childhood malnutrition 1–4 . Designing effective microbiome-directed therapeutic foods to repair these perturbations requires knowledge about how food components interact with the microbiome to alter i...
Jeffrey I. Gordon, Michael J. Barratt, Matthew C. Hibberd, Mustafizur Rahman et al.
Studies of the human microbiome are progressing rapidly but have largely focused on populations living in high-income countries. With increasing evidence that the microbiome contributes to the pathogenesis of diseases that affect infants, children, and adults in low- and middle-income countries (LMI...
Kali M. Pruss, C.-Y. Kao, Alexandra Byrne, Robert Y. Chen et al.
Environmental enteric dysfunction (EED), a small intestinal disorder prevalent in undernourished children with stunted growth and their undernourished mothers, is associated with gut mucosal barrier disruption and decreased absorptive capacity. Here we provide preclinical evidence that intergenerati...
Hibberd, Matthew
Evidence is emerging that perturbed postnatal gut microbiota development is causally related to childhood undernutrition. Clinical trials in undernourished Bangladeshi children found that a polysaccharide-rich, microbiota-directed complementary food (MDCF-2) designed to repair this perturbation prod...
Hibberd, Matthew
Evidence is emerging that perturbed postnatal gut microbiota development is causally related to childhood undernutrition. Clinical trials in undernourished Bangladeshi children found that a polysaccharide-rich, microbiota-directed complementary food (MDCF-2) designed to repair this perturbation prod...
William Yi Wang, Hao-Wei Chang, Jiye Cheng, Daniel M. Webber et al.
Studies have implicated perturbations in the postnatal development of the gut microbiome as a contributing factor to childhood undernutrition. Compared to a standard ready-to-use supplementary food, a microbiome-directed complementary food (MDCF-2) designed to repair these perturbations produced sup...
Yi Wang, Hao-Wei Chang, Jiye Cheng, Daniel M. Webber et al.
ABSTRACT Studies have implicated perturbations in the postnatal development of the gut microbiome as a contributing factor to childhood undernutrition. Compared to a standard ready-to-use supplementary food, a microbiome-directed complementary food (MDCF-2) designed to repair these perturbations pro...
Ishita Mostafa, Tahmeed Ahmed, Per Ashorn, Michael J. Barratt et al.
outcome.We designed a defined bacterial consortium that represents the human infant gut microbiome and screened the effects of specific dietary variables in KD on microbial community structure and function in order to identify the dietary components that elicit the most striking alterations in the m...