A. Louis Bourgeois, Thomas F. Wierzba, Richard I. Walker
Enterotoxigenic Escherichia coli (ETEC) is one of the most common bacterial causes of diarrhea-associated morbidity and mortality, particularly among infants and young children in developing countries. Still, the true impact on child and traveler health is likely underestimated. There are currently ...
Anna Lundgren, Louis Bourgeois, Nils Carlin, John D. Clements et al.
BACKGROUND: We have developed a new oral vaccine against enterotoxigenic Escherichia coli (ETEC), which is the most common cause of bacterial diarrhea in children in developing countries and in travelers. METHODS: The vaccine was tested for safety and immunogenicity alone and together with double-mu...
Ibrahim Khalil, Richard I. Walker, Chad K. Porter, Farzana Muhib et al.
Diarrhoeal disease attributable to enterotoxigenic Escherichia coli (ETEC) causes substantial morbidity and mortality predominantly in paediatric populations in low- and middle-income countries. In addition to acute illness, there is an increasing appreciation of the long-term consequences of enteri...
Firdausi Qadri, Marjahan Akhtar, Taufiqur Rahman Bhuiyan, Mohiul Islam Chowdhury et al.
BACKGROUND: Enterotoxigenic Escherichia coli causes diarrhoea, leading to substantial mortality and morbidity in children, but no specific vaccine exists. This trial tested an oral, inactivated, enterotoxigenic E coli vaccine (ETVAX), which has been previously shown to be safe and highly immuongenic...
Ingrid Bölin, Gudrun Wiklund, Firdausi Qadri, Olga Torres et al.
Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea among children in developing countries and in travelers to areas of ETEC endemicity. ETEC strains isolated from humans may produce a heat-labile enterotoxin (LT) and two types of the heat-stable enterotoxin STa, called STh and...
Marjahan Akhtar, Mohiul Islam Chowdhury, Taufiqur Rahman Bhuiyan, Joanna Kaim et al.
The safety and immunogenicity of the second generation oral enterotoxigenic Escherichia coli (ETEC) vaccine ETVAX, consisting of inactivated recombinant E. coli strains over-expressing the colonization factors (CFs) CFA/I, CS3, CS5 and CS6 and the heat labile toxoid LCTBA, were evaluated in Banglade...
Ann‐Mari Svennerholm, Firdausi Qadri, Anna Lundgren, Joanna Kaim et al.
We tested an oral enterotoxigenic Escherichia coli (ETEC) vaccine, ETVAX, consisting of inactivated E. coli overexpressing the most prevalent ETEC colonization factors (CFs) and a toxoid (LCTBA), in Bangladeshi children for capacity to induce mucosal and plasma immune responses against O78 lipopolys...
James Hutchenreuther, John Nguyen, Katherine Quesnel, Krista M. Vincent et al.
Melanoma is the leading cause of skin cancer-related death. As prognosis of patients with melanoma remains problematic, identification of new therapeutic targets remains essential. Matricellular proteins are nonstructural extracellular matrix proteins. They are secreted into the tumor microenvironme...
Taufiqur Rahman Bhuiyan, Farhana Khanam, Salima Raiyan Basher, Pinki Dash et al.
Introduction: (ETEC) is a common cause of acute watery diarrhea in areas lacking access to clean water, sanitation, and hygiene. This Phase 1 trial measured the safety and immunogenicity of double-mutant heat-labile enterotoxin (dmLT) of ETEC in healthy adults in Bangladesh, where ETEC is endemic. M...
Soumalya Banerjee, Eileen M. Barry, Shahida Baqar, A. Louis Bourgeois et al.
The global nonprofit organization PATH hosted the third Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference in Washington, DC, on November 29 to December 1, 2022. With a combination of plenary sessions and posters, keynote presentations, and breakout workshops, the 2022 ...
Allen G. Ross, Farhana Khanam, Md Taufiqul Islam, Fahima Chowdhury et al.
•Acute enteropathogens are a common cause of gastrointestinal illness in travelers•Initial clinical assessment is critical in determining the severity of disease•Diagnosis typically comprises culture, enzyme-linked immunosorbent assay, or polymerase chain reaction•Management depends on the severity ...
Md. Mahfuj Hassan Bhuiyan
The book Khowabmana by Akhtaruzzaman Elias reflects the 'hegemony' of the bourgeoisie class: in the beginning of the novel as Jamindars and later on as emerging capitalists.The hegemony puts the planters like Tameez under a 'false consciousness' that leads him to extreme misery.Thus, he becomes the ...
A. Louis Bourgeois, Daniel A. Scott, Shahida Baqar, David R. Tribble et al.
Cholera has re-emerged as a major global public health threat. Orally administered attenuated or inactivated vaccines offer protection against enteric pathogens such as Vibrio cholerae , and several World Health Organization-prequalified oral cholera vaccines are used globally as part of internation...
Taufiqur Rahman Bhuiyan (7225076), Farhana Khanam (192306), Salima Raiyan Basher (7115087), Pinki Dash (5130617) et al.
Introduction Enterotoxigenic Escherichia coli (ETEC) is a common cause of acute watery diarrhea in areas lacking access to clean water, sanitation, and hygiene. This Phase 1 trial measured the safety and immunogenicity of double-mutant heat-labile enterotoxin (dmLT) of ETEC in healthy adults in Bang...
David A. Sack, A. Louis Bourgeois, Subhra Chakraborty
The paper by Chowdhury describing the epidemiological and clinical features of Enterotoxigenic E. coli (ETEC) in Dhaka, Bangladesh used the clinical and microbiological data from a large cholera vaccine trial in which cases of watery diarrhea sought clinical care at a facility [ref].Some of these pa...