Alexandre F. Aissa, Abul Bashar Mir Md. Khademul Islam, Majd Ariss, Cammille C. Go et al.
Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However, the duration of clinical response is often limited, and patients ultimately develop drug resistance. Here, we u...
Lorenzo de la Rica, Javier Rodríguez‐Ubreva, Mireia García, Abul Bashar Mir Md. Khademul Islam et al.
BACKGROUND: DNA methylation is a key epigenetic mechanism for driving and stabilizing cell-fate decisions. Local deposition and removal of DNA methylation are tightly coupled with transcription factor binding, although the relationship varies with the specific differentiation process. Conversion of ...
Mercedes Herrera, Abul Bashar Mir Md. Khademul Islam, Alberto Herrera, Paloma Martín et al.
PURPOSE: Cancer-associated fibroblasts (CAF) actively participate in reciprocal communication with tumor cells and with other cell types in the microenvironment, contributing to a tumor-permissive neighborhood and promoting tumor progression. The aim of this study is the characterization of how CAFs...
Md. Abdullah‐Al‐Kamran Khan, Md. Rabi Us Sany, Md. Shafiqul Islam, Abul Bashar Mir Md. Khademul Islam
Detailed molecular mechanism of SARS-CoV-2 pathogenesis is still elusive to address its deadlier nature and to design effective theraputics. Here, we present our study elucidating the interplay between the SARS-CoV and SARS-CoV-2 viruses’; and host’s miRNAs, an epigenetic regulator, as a mode of pat...
Leonor Gama-Norton, Eva Ferrando, Cristina Ruiz‐Herguido, Zhenyi Liu et al.
Acquisition of the arterial and haemogenic endothelium fates concurrently occur in the aorta-gonad-mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The arterial programme depends on Dll4 and the haemogenic endothelium/HSC on Jag1-mediated Notch1 signalling. How Notch1 dis...
Lorenzo de la Rica, José Urquiza, David Gómez-Cabrero, Abul Bashar Mir Md. Khademul Islam et al.
Autoimmune rheumatic diseases are complex disorders, whose etiopathology is attributed to a crosstalk between genetic predisposition and environmental factors. Both variants of autoimmune susceptibility genes and environment are involved in the generation of aberrant epigenetic profiles in a cell-sp...
Chiara Di Vona, Daniela Bezdan, Abul Bashar Mir Md. Khademul Islam, Eulàlia Salichs et al.
DYRK1A is a dosage-sensitive protein kinase that fulfills key roles during development and in tissue homeostasis, and its dysregulation results in human pathologies. DYRK1A is present in both the nucleus and cytoplasm of mammalian cells, although its nuclear function remains unclear. Genome-wide ana...
Abul Bashar Mir Md. Khademul Islam, Md. Abdullah‐Al‐Kamran Khan
An incomplete understanding of the molecular mechanisms behind impairment of lung pathobiology by COVID-19 complicates its clinical management. In this study, we analyzed the gene expression pattern of cells obtained from biopsies of COVID-19-affected patient and compared to the effects observed in ...
Renáta Váraljai, Abul Bashar Mir Md. Khademul Islam, Michael L. Beshiri, Jalees Rehman et al.
The retinoblastoma tumor suppressor protein pRb restricts cell growth through inhibition of cell cycle progression. Increasing evidence suggests that pRb also promotes differentiation, but the mechanisms are poorly understood, and the key question remains as to how differentiation in tumor cells can...
Pablo Gómez‐del Arco, Eusebio Perdiguero, Paula Sofía Yunes-Leites, Rebeca Acín‐Pérez et al.
Heart muscle maintains blood circulation, while skeletal muscle powers skeletal movement. Despite having similar myofibrilar sarcomeric structures, these striated muscles differentially express specific sarcomere components to meet their distinct contractile requirements. The mechanism responsible i...
Jordi Guiu, Dylan J. M. Bergen, Emma de Pater, Abul Bashar Mir Md. Khademul Islam et al.
Hematopoietic stem cell (HSC) specification occurs in the embryonic aorta and requires Notch activation; however, most of the Notch-regulated elements controlling de novo HSC generation are still unknown. Here, we identify putative direct Notch targets in the aorta-gonad-mesonephros (AGM) embryonic ...
Mary Truscott, Abul Bashar Mir Md. Khademul Islam, Maxim V. Frolov
The importance of microRNAs in gene expression and disease is well recognized. However, what is less appreciated is that almost half of miRNA genes are organized in polycistronic clusters and are therefore coexpressed. The mir-11∼998 cluster consists of two miRNAs, miR-11 and miR-998. Here, we descr...
Bruna Barneda‐Zahonero, Olga Collazo, Alba Azagra, Irene Fernández-Duran et al.
The generation of B cells is a complex process requiring several cellular transitions, including cell commitment and differentiation. Proper transcriptional control to establish the genetic programs characteristic of each cellular stage is essential for the correct development of B lymphocytes. Dere...
Abul Bashar Mir Md. Khademul Islam, Md. Abdullah‐Al‐Kamran Khan, Rasel Ahmed, Md. Sabbir Hossain et al.
Abstract Background Although it is becoming evident that individual’s immune system has a decisive influence on SARS-CoV-2 disease progression, pathogenesis is largely unknown. In this study, we aimed to profile the host transcriptome of COVID-19 patients from nasopharyngeal samples along with virus...
María Carmen Mulero, Dolors Ferrés-Marcó, Abul Bashar Mir Md. Khademul Islam, Pol Margalef et al.
IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of HOX and IRX genes. Chromatin-bound IκBα modulates Polycomb recruitment and imp...