Mihai Pop, Alan W. Walker, Joseph N. Paulson, Brianna Lindsay et al.
BACKGROUND: Diarrheal diseases continue to contribute significantly to morbidity and mortality in infants and young children in developing countries. There is an urgent need to better understand the contributions of novel, potentially uncultured, diarrheal pathogens to severe diarrheal disease, as ..
Roberto Pecoits‐Filho, Ikechi G. Okpechi, Jo‐Ann Donner, David C.H. Harris et al.
A large gap between the number of people with end-stage kidney disease (ESKD) who received kidney replacement therapy (KRT) and those who needed it has been recently identified, and it is estimated that approximately one-half to three-quarters of all people with ESKD in the world may have died prema...
Firdausi Qadri, Marjahan Akhtar, Taufiqur Rahman Bhuiyan, Mohiul Islam Chowdhury et al.
BACKGROUND: Enterotoxigenic Escherichia coli causes diarrhoea, leading to substantial mortality and morbidity in children, but no specific vaccine exists. This trial tested an oral, inactivated, enterotoxigenic E coli vaccine (ETVAX), which has been previously shown to be safe and highly immuongenic...
Marjahan Akhtar, Mohiul Islam Chowdhury, Taufiqur Rahman Bhuiyan, Joanna Kaim et al.
The safety and immunogenicity of the second generation oral enterotoxigenic Escherichia coli (ETEC) vaccine ETVAX, consisting of inactivated recombinant E. coli strains over-expressing the colonization factors (CFs) CFA/I, CS3, CS5 and CS6 and the heat labile toxoid LCTBA, were evaluated in Banglade...
Rubhana Raqib, Protim Sarker, Khalequ Zaman, Nur Alam et al.
Shigella sonnei live vaccine candidate, WRSS1, which was previously evaluated in US, Israeli and Thai volunteers, was administered orally to Bangladeshi adults and children to assess its safety, clinical tolerability and immunogenicity. In a randomized, placebo-controlled, dose-escalation, age-desce...
Brianna Lindsay, Joe Oundo, M. Anowar Hossain, Martín Antonio et al.
Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 ...
Brianna Lindsay, Mihai Pop, Martín Antonio, Alan W. Walker et al.
Cultivation-based assays combined with PCR or enzyme-linked immunosorbent assay (ELISA)-based methods for finding virulence factors are standard methods for detecting bacterial pathogens in stools; however, with emerging molecular technologies, new methods have become available. The aim of this stud...
Paolo Peterlongo, Jenny Chang-Claude, Kirsten B. Moysich, Anja Rudolph et al.
BACKGROUND: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In thi...
Alan G. Fantel, Jean C. Greenaway, Evan Harris Walker, Mont R. Juchau
The antischistosomal drug niridazole (NDZ) was found to be teratogenic in a concentration-dependent manner from 10 to 50 micrograms/ml (47-233 microM) in rat embryos cultured from day 10 to day 11. A striking malformation consisting of axial asymmetry in which the right side of the embryo showed sev...
Arlie McCarthy, Daniel Steadman, Hannah Richardson, Jack Murphy et al.
Abstract Numerous policy and international frameworks consider that “destructive fishing” hampers efforts to reach sustainability goals. Though ubiquitous, “destructive fishing” is undefined and therefore currently immeasurable. Here we propose a definition developed through expert consultation: “De...
Janet Johnston, Malene Jensen, Lars Lannfelt, Brian Walker et al.
Abeta peptides are major components of the amyloid plaques that characterize Alzheimer's disease. The enzyme activities (beta- and gamma-secretases) involved in generating Abeta from amyloid precursor protein (APP) are unidentified. It has been suggested that prolylendopeptidase (PEP), an oligopepti...
Cynthia J. Burrows, Shu Wang, Hyun Jae Kim, Gerald J. Meyer et al.
The research community faces unprecedented disruption from the global COVID-19 pandemic. Some researchers are beginning to return to lab work after a hiatus, but others continue to work as best as they can from home, including ourselves. The global editorial, support, and production staff of ACS jou...
Alan D. Phillips
Queen Elizabeth Hospital for Children, (“Queens”) where this story begins, was situated in the East End of London, in an area of overcrowding and social deprivation, and a place for the first settlement of immigrants into the country. The hospital itself was founded in response to a cholera epidemic...
Robyn Smith
Heading into the August 2024 general election, the Fyles ALP Government is facing growing community unrest about the levels of youth crime, property damage, injury and death. Protests spread from Alice Springs to Darwin where six northern suburbs electorates traditionally determine electoral fortune...
Alan D. Phillips
Queen Elizabeth Hospital for Children, (“Queens”) where this story begins, was situated in the East End of London, in an area of overcrowding and social deprivation, and a place for the first settlement of immigrants into the country. The hospital itself was founded in response to a cholera epidemic...