Annette Pflugfelder, Corinna Kochs, Andreas Blum, Marcus Capellaro et al.
This first German evidence-based guideline for cutaneous melanoma was developed under the auspices of the German Dermatological Society (DDG) and the Dermatologic Cooperative Oncology Group (DeCOG) and funded by the German Guideline Program in Oncology. The recommendations are based on a systematic ...
Joachim Heinrich, Ulrike Gehring, Jeroen Douwes, Andrea Koch et al.
BACKGROUND: Previous studies have shown that the risk for allergic sensitization is lower in children who grew up on farms and in young adults who were exposed to dogs in early childhood. A higher microbial exposure in general and in particular to endotoxin in early childhood might contribute to thi...
Pietro Nenoff, Shyam B. Verma, Andreas Ebert, Anke Süß et al.
Chronic recalcitrant dermatophytoses, due to Trichophyton (T.) mentagrophytes Type VIII are on the rise in India and are noteworthy for their predominance. It would not be wrong to assume that travel and migration would be responsible for the spread of T. mentagrophytes Type VIII from India, with ma...
Annette Pflugfelder, Corinna Kochs, Andreas Blum, Marcus Capellaro et al.
Moritz Jesinghaus, Johanna Strehl, Melanie Boxberg, Frido Brühl et al.
A novel histopathological grading system based on tumour budding and cell nest size has recently been shown to outperform conventional (WHO-based) grading algorithms in several tumour entities such as lung, oral, and oesophageal squamous cell carcinoma (SCC) in terms of prognostic patient stratifica...
Maren Freigang, Claudia D. Wurster, Tim Hagenacker, Benjamin Stolte et al.
OBJECTIVE: To determine whether serum creatine kinase activity (CK) and serum creatinine concentration (Crn) are prognostic and predictive biomarkers for disease severity, disease progression, and nusinersen treatment effects in adult patients with 5q-associated spinal muscular atrophy (SMA). METHOD...
Léon Beyer, René Günther, Jan Christoph Koch, Stephan Klebe et al.
Pathologic alterations of Transactivation response DNA-binding protein 43 kilo Dalton (TDP-43) are a major hallmark of amyotrophic lateral sclerosis (ALS). In this pilot study, we analyzed the secondary structure distribution of TDP-43 in cerebrospinal fluid of ALS patients (n = 36) compared to Park...
Johanna S Canenguez Benitez, Tabata E Hernandez, Ramaswamy Sundararajan, Sarosh Sarwar et al.
BACKGROUND AND OBJECTIVES: St. John's wort (SJW) extracts are currently being used to treat depression of various degrees of severity. While many studies have shown it to be superior to placebo, data regarding the effectiveness of using SJW as a stand-alone treatment compared with standard antidepre...
Franziska Langhammer, Reza Maroofian, Rueda Badar, Anne Gregor et al.
Purpose: Missense variants clustering in the BTB domain region of RHOBTB2 cause a developmental and epileptic encephalopathy with early-onset seizures and severe intellectual disability. Methods: By international collaboration, we assembled individuals with pathogenic RHOBTB2 variants and a variable...
Maren Freigang, Petra Steinacker, Claudia D. Wurster, Olivia Schreiber‐Katz et al.
OBJECTIVE: Activated astroglia is involved in the pathophysiology of neurodegenerative diseases and has also been described in animal models of spinal muscular atrophy (SMA). Given the urgent need of biomarkers for treatment monitoring of new RNA-modifying and gene replacement therapies in SMA, we e...
Vukašin Gligorić, John T. Jost, Iva Mićanović, Odeta Tase et al.
The assumption that people favor ingroups and disfavor outgroups is based largely on theory and research from Western countries. However, groups subjected to economic exploitation and inequality might come to favor more advantaged outgroups. The present large-scale study ( N = 12,339) involving 45 n...
Shenghui Li, Charles Izuma Addey, Raphaël Roman, Hakase Hayashida et al.
This paper highlights the urgent need to accelerate research and action on ocean carbon sinks through human intervention, known as the Global Ocean Negative Carbon Emissions (Global-ONCE) Programme, as a vital strategy in global efforts to mitigate climate change. Achieving "net zero" by 2050 cannot...
Kajus Merkevičius, Dmitrii Smirnov, Lea D. Schlieben, Rebecca Ganetzky et al.
This retrospective study on X-linked PDHA1-related pyruvate dehydrogenase complex (PDHc) deficiency combined a systematic literature review with a multicenter survey exploring genotypes, phenotypes, and survival. Data from 891 individuals (45% unpublished) were included. Of note, 53% of cases were f...
Mohammad Shahidul Islam, Naito Kanon, Samin Huq, Mohammad Shameem Hassan et al.
Background: Respiratory syncytial virus (RSV) is a major cause of acute respiratory infection (ARI) in young children, but evidence on burden from low- and middle-income countries has largely been derived from hospital-based studies. This prospective, community-based study estimated the burden of RS...
Mike Bennett
Health & History ● 19/2 ● 2017 169 Inquiry’s findings is included in an appendix. The book’s photographs and diagrams (some of which explain CIS progression) provide additional context. As the first comprehensive account of the Cartwright Inquiry written by a ‘whistle-blower’ NWH doctor, Doctors in ...