R.C. Hughes, J. G. Polgar, Andrew Weightman, J. N. Walton
A double-blind cross-over trial over 24 weeks (10 weeks on the active remedy, 4 weeks off treatment, and 10 weeks on placebo) of the effect of L-dopa on idiopathic Parkinsonism (paralysis agitans) has shown no difference in the response obtained in patients who had undergone previous stereotaxic ven...
Paolo Peterlongo, Jenny Chang-Claude, Kirsten B. Moysich, Anja Rudolph et al.
BACKGROUND: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In thi...
Andrew Brady
With Innovation and Scaling for Impact: How Effective Social Enterprises Do It, Christian Seelos and Johanna Mair offer an insightful and theory-rich contribution to the academic literature on this topic, based on their work with social enterprises over a decade or more. In particular, they explore ...
Daniel W. Wheeler, Tze Vun Liew, Andrew Bailey
A 47-year-old woman presented for mastectomy and immediate latissimus dorsi flap reconstruction having been diagnosed with carcinoma of the breast 6 months previously. In the preceding months she had received neo-adjuvant chemotherapy with epirubicin, paclitaxel (Taxol) and cyclophosphamide. This ha...
J. McAleese, K. Drinkwater, A. Bedair, Anthony Williams et al.
AIMS The Royal College of Radiologists (RCR) audit of radical radiotherapy (RR) for patients with non-small cell lung cancer (NSCLC) in 2013 concluded that there was under-treatment compared to international comparators and marked variability between cancer networks. Elderly patients were less likel...
Kathryn Foti, Andrew E. Moran, Kunihiro Matsushita, Lawrence J. Appel et al.
The current guideline-recommended clinic blood pressure (BP) measurement procedure takes nearly 10 minutes to complete and may not be feasible to implement in busy clinical practice settings. Additionally, evidence supporting the steps in the current guideline-recommended procedure is of uneven qual...
Paul McLoughlin, Noel McCaffrey, R. G. O’Regan, M. K. Hammad et al.
Bunmi Ogungbe, Xiao Hu, Tasfia Hussain, Binh Nguyen et al.
Background: To massively scale up efforts to diagnose and treat hypertension, different screening strategies have been proposed (population-wide screening campaigns and healthcare facility-based “opportunistic” screening). However, no studies have compared their impact on cardiovascular disease (CVD...
Junayd Hussain, Kalina Georgieva, Cal Robinson, Nivethika Jeyakumar et al.
Bunmi Ogungbe, Xiao Hu, Tasfia Hussain, Binh Huy Nguyen et al.
Background: Hypertension (HTN) is a major risk factor for cardiovascular diseases (CVD). The World Health Organization recommends opportunistic screening, defined as measuring blood pressure (BP) during routine healthcare visits even for unrelated reasons. However, implementation of this approach re...
Andrew Brady
With Innovation and Scaling for Impact: How Effective Social Enterprises Do It, Christian Seelos and Johanna Mair offer an insightful and theory-rich contribution to the academic literature on this topic, based on their work with social enterprises over a decade or more. In particular, they explore ...
Andrew Brady Spalding
Recent reports of egregious labor practices in China and Bangladesh have called public attention to the potential harms of foreign direct investment (FDI) in developing countries. The best, or at least most obvious, tool for reducing destructive overseas business practices would seem to be the extra...