Christine D. Palmer, Amy Rappaport, Matthew J. Davis, Meghan G. Hart et al.
Checkpoint inhibitor (CPI) therapies provide limited benefit to patients with tumors of low immune reactivity. T cell-inducing vaccines hold promise to exert long-lasting disease control in combination with CPI therapy. Safety, tolerability and recommended phase 2 dose (RP2D) of an individualized, h...
Andrew S. Ferguson, Alice C. Layton, Brian J. Mailloux, Patricia J. Culligan et al.
Groundwater is routinely analyzed for fecal indicators but direct comparisons of fecal indicators to the presence of bacterial and viral pathogens are rare. This study was conducted in rural Bangladesh where the human population density is high, sanitation is poor, and groundwater pumped from shallo...
Martin O’Donnell, Andrew Mente, Sumathy Rangarajan, Matthew McQueen et al.
OBJECTIVE: To evaluate the joint association of sodium and potassium urinary excretion (as surrogate measures of intake) with cardiovascular events and mortality, in the context of current World Health Organization recommendations for daily intake (<2.0 g sodium, >3.5 g potassium) in adults. DESIGN:...
Brian J. Mailloux, Elizabeth Trembath‐Reichert, Jennifer Ren-Si Cheung, Marlena Watson et al.
Chronic exposure to arsenic (As) by drinking shallow groundwater causes widespread disease in Bangladesh and neighboring countries. The release of As naturally present in sediment to groundwater has been linked to the reductive dissolution of iron oxides coupled to the microbial respiration of organ...
Alexander van Geen, Kazi Matin Ahmed, Yasuyuki Tsuboi, Md Jahangir Alam et al.
The health risks of As exposure due to the installation of millions of shallow tubewells in the Bengal Basin are known, but fecal contamination of shallow aquifers has not systematically been examined. This could be a source of concern in densely populated areas with poor sanitation because the hydr...
Brian L. Browning, Claudia Hüebner, Ivonne Petermann, Richard B. Gearry et al.
OBJECTIVES: Published association studies of the TLR4 Asp299Gly polymorphism and inflammatory bowel disease (IBD) in caucasian populations have inconsistent results. We tested two TLR4 variants for association with IBD in the New Zealand caucasian population and assessed the cumulative evidence for ...
Jianyong Wu, Alexander van Geen, Kazi Matin Ahmed, Yasuyuki Akita Jahangir Alam et al.
BACKGROUND: Millions of households throughout Bangladesh have been exposed to high levels of arsenic (As) causing various deadly diseases by drinking groundwater from shallow tubewells for the past 30 years. Well testing has been the most effective form of mitigation because it has induced massive s...
Peter S.K. Knappett, Larry D. McKay, Alice C. Layton, Daniel E. Williams et al.
Bangladesh is underlain by shallow aquifers in which millions of drinking water wells are emplaced without annular seals. Fecal contamination has been widely detected in private tubewells. To evaluate the impact of well construction on microbial water quality 35 private tubewells (11 with intact cem...
Andrew S. Ferguson, Brian J. Mailloux, Kazi Matin Ahmed, Alexander van Geen et al.
The retention and release of total coliforms and Escherichia coli was investigated in hand-pumps removed from tubewells tapping a faecally contaminated aquifer in Matlab, Bangladesh, and from a new hand-pump deliberately spiked with E. coli. All hand-pumps were connected to reservoirs of sterile wat...
Jianyong Wu, Alexander van Geen, Kazi Matin Ahmed, Yasuyuki Akita et al.
Background: Millions of households throughout Bangladesh have been exposed to high levels of arsenic (As) causing various deadly diseases by drinking groundwater from shallow tubewells for the past 30 years. Well testing has been the most effective form of mitigation because it has induced massive s...
John Feighery, Brian J. Mailloux, Andrew S. Ferguson, Kazi Matin Ahmed et al.
Fecal bacteria are frequently found at much greater distances than would be predicted by laboratory studies, indicating that improved models that incorporate more complexity might be needed to explain the widespread contamination of many shallow aquifers. In this study, laboratory measurements of br...
Alice C. Layton, Archana Chauhan, Daniel E. Williams, Brian J. Mailloux et al.
The contamination of drinking water from both arsenic and microbial pathogens occurs in Bangladesh. A general metagenomic survey of well water and surface water provided information on the types of pathogens present and may help elucidate arsenic metabolic pathways and potential assay targets for mo...
Marc L. Serre, Yasuyuki Akita Jahangir Alam, Michael Emch, Kazi Matin Ahmed et al.
BackgroundMillions of households throughout Bangladesh have been exposed to high levels of arsenic (As) causing various deadly diseases by drinking groundwater from shallow tubewells for the past 30 years. Well testing has been the most effective form of mitigation because it has induced massive swi...
Xiaoru Li, Shrayesh N. Patel, Stuart J. Rowan, Andrew L. Ferguson et al.
Organic Ionic Plastic Crystals (OIPCs) are a unique class of polycrystalline solid-state electrolytes that combine long-range structural order with localized rotational disorder, enabling both mechanical compressibility and ion transport. Unlike conventional crystalline or amorphous solid electrolyt...
Yongkang Xi, Jianming Mao, Samuel J. Chen, Hossein Moghimianavval et al.
Cytoplasmic abundant heat-soluble (CAHS) proteins, a stress-responsive intrinsically disordered protein from tardigrades, have been discovered to form gel-like networks providing structural support during dehydration, thus enabling anhydrobiosis. However, the mechanism by which CAHS proteins protect...
Vered Amit, Nelson Ferguson, Andrew Irving, Tord Larsen et al.
Andrew S. Ferguson, Daniel E. Williams, Brian J. Mailloux, Gary S. Sayler et al.
Groundwater is routinely analyzed for fecal indicators but direct comparisons of fecal indicators to the presence of bacterial and viral pathogens are rare. This study was conducted in rural Bangladesh where the human population density is high, sanitation is poor, and groundwater pumped from shallo...
Gary S. Sayler, Peter S.K. Knappett, Kazi Matin Ahmed, Alice C. Layton et al.
Bangladesh is underlain by shallow aquifers in which millions of drinking water wells are emplaced without annular seals. Fecal contamination has been widely detected in private tubewells. To evaluate the impact of well construction on microbial water quality 35 private tubewells (11 with intact cem...
P. Kim Streatfield, Alice C. Layton, Jacob L. Mey, Andrew S. Ferguson et al.
The health risks of As exposure due to the installation of millions of shallow tubewells in the Bengal Basin are known, but fecal contamination of shallow aquifers has not systematically been examined. This could be a source of concern in densely populated areas with poor sanitation because the hydr...
Ann Ferguson, Kristen Van Hooreweghe, John Gulick, Hobart A. Spalding et al.