Anne K. Bozack, Megan N. Hall, Xinhua Liu, Vesna Ilievski et al.
Background Arsenic exposure through drinking water persists in many regions. Inorganic As (InAs) is methylated to monomethyl-arsenical species (MMAs) and dimethyl-arsenical species (DMAs), facilitating urinary excretion. Arsenic methylation is dependent on one-carbon metabolism, which is influenced ...
Anne K. Bozack, Andrés Cárdenas, Quazi Quamruzzaman, Mahmuder Rahman et al.
Prenatal arsenic exposure is associated with adverse birth outcomes and disease risk later in life, which could be mediated through epigenetic dysregulation. We evaluated the association between arsenic and gestational age (GA) that was mediated through DNA methylation (DNAm) using data from a Bangl...
Anne K. Bozack, Philippe Boileau, Linqing Wei, Alan Hubbard et al.
BACKGROUND: Arsenic (As) exposure through drinking water is a global public health concern. Epigenetic dysregulation including changes in DNA methylation (DNAm), may be involved in arsenic toxicity. Epigenome-wide association studies (EWAS) of arsenic exposure have been restricted to single populati...
Anne K. Bozack, Andrés Cárdenas, John Geldhof, Quazi Quamruzzaman et al.
Background: Fetal epigenetic programming plays a critical role in development. DNA methyltransferase 3 alpha (DNMT3A), which is involved in de novo DNA methylation (DNAm), is a prime candidate gene as a mediator between prenatal exposures and birth outcomes. We evaluated the relationships between in...
Ahlam Abuawad, Anne K. Bozack, Ana Navas‐Acién, Jeff Goldsmith et al.
Background: Chronic arsenic (As) exposure is a global environmental health issue. Inorganic As (InAs) undergoes methylation to monomethyl (MMAs) and dimethyl-arsenical species (DMAs); full methylation to DMAs facilitates urinary excretion and is associated with reduced risk for As-related health out...
Anne K. Bozack, Caitlin G. Howe, Megan N. Hall, Xinhua Liu et al.
Methylation of ingested inorganic arsenic (InAs) to monomethyl- (MMAs) and dimethyl-arsenical species (DMAs) facilitates urinary arsenic elimination. Folate and creatine supplementation influenced arsenic methylation in a randomized controlled trial. Here, we examine if baseline status of one-carbon...
Arce Domingo‐Relloso, Anne K. Bozack, Samara Kiihl, Zulema Rodriguez-Hernandez et al.
Background: Associations of arsenic (As) with the sum of 5-mC and 5-hmC levels have been reported; however, As exposure-related differences of the separated 5-mC and 5-hmC markers have rarely been studied. Methods: In this study, we evaluated the association of arsenic exposure biomarkers and 5-mC a...
Ahlam Abuawad, Anne K. Bozack, Ana Navas‐Acién, Jeff Goldsmith et al.
Background and Aim. Arsenic exposure is a global issue. Inorganic As (InAs) undergoes methylation to monomethyl (MMAs) and dimethyl-arsenical species (DMAs); full methylation to DMAs facilitates urinary excretion and can reduce risk of adverse health outcomes. Folate and creatine influence one-carbo...
Anne K. Bozack, Megan Hall, Xiang Liu, Vesna Ilievski et al.
TPS 621: Exposure to metals, Johan Friso Foyer, Floor 1, August 26, 2019, 3:00 PM - 4:30 PM Background/Aim: Arsenic exposure through drinking water affects at least 40 million people in Bangladesh and 140 million people worldwide. Inorganic arsenic (InAs) is methylated to mono- (MMAs) and di-methyl ...
James L Li, Niyati Jain, Lizeth I. Tamayo, Lin Tong et al.
BACKGROUND: Inorganic arsenic (As) is a carcinogen and >200 million people worldwide are exposed to As through drinking water. Long-term As exposure increases the risk of chronic diseases including cancer and cardiovascular disease. While prior work has identified several genomic regions where DNA m...
Amy M. Inkster, Anne K. Bozack, Bernardo Lemos, Tabitha Lumour-Mensah et al.
- Maternal DNA methylation is responsive to arsenic, folate, and offspring spina bifida.
Amy M. Inkster, Anne K. Bozack, Bernardo Lemos, Tabitha Lumour-Mensah et al.
Supplementary Material 2
Amy M. Inkster, Anne K. Bozack, Bernardo Lemos, Tabitha Lumour-Mensah et al.
Supplementary Material 1
Amy M. Inkster, Anne K. Bozack, Bernardo Lemos, Tabitha Lumour-Mensah et al.
Supplementary Material 1
Amy M. Inkster, Anne K. Bozack, Bernardo Lemos, Tabitha Lumour-Mensah et al.
Abstract Background In Bangladesh, more than a quarter of drinking water tubewells are contaminated with arsenic above the national standard (50 µg/l), while nearly half exceed the World Health Organization guideline (10 µg/l). Among other negative health consequences, arsenic is a suspected environ...