Justina X. Caushi, Jiajia Zhang, Zhicheng Ji, Ajay Vaghasia et al.
Abstract PD-1 blockade unleashes CD8 T cells 1 , including those specific for mutation-associated neoantigens (MANA), but factors in the tumour microenvironment can inhibit these T cell responses. Single-cell transcriptomics have revealed global T cell dysfunction programs in tumour-infiltrating lym...
Lili Zhang, Daniel A. Zlotoff, Magid Awadalla, Syed Mahmood et al.
Introduction: myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI). While corticosteroids are the cornerstones of the treatment, there are no data to guide the dose and timing.\n\nMethods: from an international registry of patients with ICI myocarditis diagnosed betw...
Charles Sheppard, Mebrahtu Ateweberhan, Brian W. Bowen, Peter Carr et al.
shallow limestone platform and reefs. This has doubled the global cover of such MPAs.It contains 25-50% of the Indian Ocean reef area remaining in excellent condition, as well as the world's largest contiguous undamaged reef area. It has suffered from warming episodes, but after the most severe mort...
Andrew D. Miall, Brian G. Jones
Abstract The Hawkesbury Sandstone has long been assumed to represent the deposits of a large braided river system, comparable in style and magnitude with the modern Brahmaputra River of Bangladesh. Such an interpretation is based mainly on the common occurrence of very large-scale crossbedding, but ...
Philip F. Souter, Graeme D. Cruickshank, Melanie Z. Tankerville, Bruce H. Keswick et al.
Contamination of drinking water by microorganisms and arsenic represents a major human health hazard in many parts of the world. An estimated 3.4 million deaths a year are attributable to waterborne diseases. Arsenic poisoning from contaminated water sources is causing a major health emergency in so...
Sheel Bansal, Irena F. Creed, Brian A. Tangen, Scott D. Bridgham et al.
Abstract Wetlands cover a small portion of the world, but have disproportionate influence on global carbon (C) sequestration, carbon dioxide and methane emissions, and aquatic C fluxes. However, the underlying biogeochemical processes that affect wetland C pools and fluxes are complex and dynamic, m...
Dominic L. Cram, Jessica E. M. van der Wal, Natalie Uomini, Maurício Cantor et al.
Abstract Human‐wildlife cooperation is a type of mutualism in which a human and a wild, free‐living animal actively coordinate their behaviour to achieve a common beneficial outcome. While other cooperative human‐animal interactions involving captive coercion or artificial selection (including domes...
* Contents * Part 1: Overview * 1. Introduction: Genocide, War Crimes and the West - Adam Jones * 2. Shades of Complicity: Towards a Typology of Transnational Crimes against Humanity - Peter Stoett * Part 2: Genocide, War Crimes and the West * 3. Imperial Germany and the Herero of Southern Africa: G...
Jessica E. M. van der Wal, Claire N. Spottiswoode, Natalie Uomini, Maurício Cantor et al.
Human-wildlife cooperation occurs when humans and free-living wild animals actively coordinate their behavior to achieve a mutually beneficial outcome. These interactions provide important benefits to both the human and wildlife communities involved, have wider impacts on the local ecosystem, and re...
Nadia I. Richman, James Gibbons, Samuel T. Turvey, Tomonari Akamatsu et al.
Detection of animals during visual surveys is rarely perfect or constant, and failure to account for imperfect detectability affects the accuracy of abundance estimates. Freshwater cetaceans are among the most threatened group of mammals, and visual surveys are a commonly employed method for estimat...
Zayid K. Almayahi, Hanan Al Kindi, C. Todd Davies, Bader Al-Rawahi et al.
Following the detection of the first human case of avian influenza A subtype H9N2 in 1998, more than 40 cases were diagnosed worldwide. However, the spread of the virus has been more remarkable and significant in global poultry populations, causing notable economic losses despite its low pathogenici...
Rebecca Sims, Sarah Dwyer, Denise Harold, Amy Gerrish et al.
We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from...
Brian J. Lenny, Karthik Shanmuganatham, Stephanie Sonnberg, Mohammed M. Feeroz et al.
Avian influenza A(H9N2) is an agricultural and public health threat. We characterized an H9N2 virus from a pet market in Bangladesh and demonstrated replication in samples from pet birds, swine tissues, human airway and ocular cells, and ferrets. Results implicated pet birds in the potential dissemi...
David W. Eyre, Sheila Lumley, Denise O’Donnell, Mark Campbell et al.
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teach...
Çharles N. Bernstein, Remo Panaccione, Zoann Nugent, Deborah A. Marshall et al.
BACKGROUND: We aimed to establish a cohort of persons with Crohn's disease (CD) enrolled from 14 Canadian centers to describe the contemporary presentation of CD in Canada. METHODS: All enrollees were at least 18 years old and underwent chart review for phenotype documentation by Montreal Classifica...