Serge M. Garcia, Jeppe Kolding, J. Rice, M.-J. Rochet et al.
Balanced fishing across a range of species, stocks, and sizes could mitigate adverse effects and address food security better than increased selectivity.
A. Mesut Erzurumluoglu, Mengzhen Liu, Victoria E. Jackson, Daniel R. Barnes et al.
Abstract Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide varia...
Daniel C. Dunn, Cindy Lee Van Dover, Ron J. Etter, Craig R. Smith et al.
Mineral exploitation has spread from land to shallow coastal waters and is now planned for the offshore, deep seabed. Large seafloor areas are being approved for exploration for seafloor mineral deposits, creating an urgent need for regional environmental management plans. Networks of areas where mi...
Daniel C. Dunn, Caroline Jablonicky, Guillermo Ortuño Crespo, Douglas J. McCauley et al.
Abstract Between 1950 and 1989, marine fisheries catch in the open‐ocean and deep‐sea beyond 200 nautical miles from shore increased by a factor of more than 10. While high seas catches have since plateaued, fishing effort continues to increase linearly. The combination of increasing effort and ille...
Ignacio Blanco, Karoline Kuchenbaecker, Daniel Cuadras, Xianshu Wang et al.
While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. Following on these observations, we further assessed the link between the...
Jeff Ardron, Sophie Arnaud‐Haond, Yannick Beaudoin, Juan Bezaury et al.
Technical Report of the International Seabed Authority.
David E. Johnson, Christopher R. S. Barrio Froján, Nicholas J. Bax, Piers K. Dunstan et al.
Abstract Addressing the challenge of protecting biodiversity in the global ocean requires a sound knowledge and understanding of the complex marine environment. Since 2008 the Global Ocean Biodiversity Initiative (GOBI) has been established as a voluntary dedicated group of marine institutions and s...
Shania M. Corry, Amy M.B. McCorry, Tamsin R.M. Lannagan, Niamh Leonard et al.
Objective Stroma-rich tumours represent a poor prognostic subtype in stage II/III colon cancer (CC), with high relapse rates and limited response to standard adjuvant chemotherapy. Design To address the lack of efficacious therapeutic options for patients with stroma-rich CC, we stratified our human...
Philip D. Dunne, Helen G. Coleman, Peter Bankhead, Matthew Alderdice et al.
Purpose: BRAF mutation occurs in 8-15% of colon cancers (CC), and is associated with poor prognosis in metastatic disease. Compared to wild-type BRAF (BRAFWT) disease, stage II/III CC patients with BRAF mutant (BRAFMT) tumors have shorter overall survival after relapse; however, time-to-relapse is n...
Kate M. Dunn, Daniel C. Cherkin
Keele University, Keele, Staffordshire, UK (Dunn) Center for Health Studies, Group Health Cooperative, Seattle, NA (Cherkin) The manuscript submitted does not contain information about medical device(s)/drug(s). Foundation funds were received in support of this work. No benefits in any form have bee...
C Rutherford, S Winward, S Towell, I Lawrie et al.
Transbronchial lung cryobiopsy (TBLC) is a promising new technique that is rapidly developing as a standard diagnostic procedure in the diagnosis of interstitial lung disease. However there continues to be a variety of non-standardised approaches taken to its implementation . We performed a retrospe...
Sarah Laing, Isabel Dye, R L Byrne, Eva Freckmann et al.
Although 30-40% of human Non-Small Cell lung cancers show low level amplification of c-MYC and genetic evidence supports c-Myc as a key downstream effector of KRas-driven tumourigenesis in mouse models, the functional contribution of MYC to human lung cancer remains unclear. We applied a phenotype-b...
A. Mesut Erzurumluoglu, Mengzhen Liu, Victoria E. Jackson, Daniel R. Barnes et al.
Abstract Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide varia...
Darragh G. McArt, Philip D. Dunne, Elaine W. Kay, Anthony O’Grady et al.
3573 Background: Despite the use of 5-FU-based adjuvant therapies, a large proportion of stage III (locally advanced) colorectal cancer (CRC) patients will relapse and die of metastatic disease. Recent data from phase III trials using the anti-VEGF or the anti-EGFR mAbs have shown that, in contrast ...
Mosiur Rahman, Golam Mostof
Although Bangladesh is on track to achieve Millennium Development Goal 4 (MDG4: reduce child mortality, approximately less than 50 per 1000 live births by 2015) (International Center for Diarrheal Disease Research, Bangladesh [ICDDR, B], 2007), child mortality rate still remains very high in this co...