Mohammad Sayed Alam, Jung‐Hyun Choi, Dong‐Ung Lee
4-Aminoantipyrine (4-amino-1,5-dimethyl-2-phenylpyrazole-3-one) and its analogues have been found to be compounds of interest for their anti-inflammatory, analgesic, antiviral, antipyretic, antirheumatic and antimicrobial activities. In the present study, Schiff base analogues of 4-aminoantipyrine w...
Mohammad Sayed Alam, Dong‐Ung Lee
A detail of the theoretical study on the molecular geometry and the infrared vibrational frequency assignments of (E)-4-(2-methoxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (MBA-dMPP), a bioactive azomethine analog of antipyrine, have been reported and compared with the experimenta...
Mohammad Sayed Alam, Young-Joo Nam, Dong‐Ung Lee
In the present study, a series of (Z)-2,3-diphenylacrylonitrile analogs were synthesized and then evaluated in terms of their cytotoxic activities against four human cancer cell lines, e.g. lung cancer (A549), ovarian cancer (SK-OV-3), skin cancer (SK-MEL-2), and colon cancer (HCT15), as well as ant...
Mohammad Sayed Alam, Dong‐Ung Lee
Two hydrazone Schiff base analogues, namely, (E)-N'-(4-hydroxy-3-methoxybenzylidene)benzohydrazide (3a) and (E)-N'-(4-methoxybenzylidene)benzohydrazide (3b), were synthesized using a mild, efficient method and characterized by (1)H NMR, mass spectrometry, elemental analysis, and single-crystal X-ray...
Mohammad Sayed Alam, Sang‐Un Choi, Dong‐Ung Lee
A series of novel salicyl-hydrazone analogues were synthesized and evaluated for their in vitro cytotoxic activities in five human cancer cell lines, namely, lung cancer (A549), ovarian cancer (SK-OV-3), skin cancer (SK-MEL-2), colon cancer (HCT15) and pancreatic cancer (MIA-PaCa-2) cells, and for t...
Mohammad Sayed Alam, Shafiur Rahman, Dong‐Ung Lee
Mohammad Sayed Alam, Dong‐Ung Lee, Md. Latiful Bari
Mohammad Sayed Alam, Dong‐Ung Lee
Mohammad Sayed Alam, Dong‐Ung Lee
A series of fifteen benzylidene-hydrazone analogues (3a-o), including eight new compounds, were synthesized and evaluated for their cytotoxic activities in four human cancer cell lines and for their antioxidant activities using DPPH. Of the tested compounds 3e, which possesses two methoxy substituen...
Mohammad Sayed Alam, Dong‐Ung Lee
Mohammad Sayed Alam, Junaid U. Ahmed, Dong‐Ung Lee
Thiazoles are an important class of heterocyclic compounds that possess a sulfur and nitrogen containing five-membered ring, which acts as a pharmacophore, and show a wide range of complex biological activities. A series of sixteen 2-arylidenehydrazinyl-4-arylthiazole analogues (3a–p) were evaluated...
Mohammad Sayed Alam, Dong‐Ung Lee
Mohammad Sayed Alam, Dong‐Ung Lee
Two novel Schiff base analogs derived from 4‐aminoantipyrine, namely, ( E )‐4‐(2‐nitrobenzylideneamino)‐1,5‐dimethyl‐2‐phenyl‐1 H ‐pyrazol‐3(2 H )‐one ( 3a ) and ( E )‐4‐(4‐nitrobenzylideneamino)‐1,5‐dimethyl‐2‐phenyl‐1 H ‐pyrazol‐3(2 H )‐one ( 3b ), were synthesized using a mild and efficient metho...
Mohammad Sayed Alam, Sanjit Saha, Dong‐Ung Lee
Mohammad Sayed Alam, Dong‐Ung Lee
AIM: The aim of the study was to search for new anticancer agents as TRKA inhibitors. BACKGROUND: A series of new salicylic acid hydrazide hydrazones were synthesized and evaluated for their in vitro anticancer activities against lung (A549), ovarian (SK-OV-3), skin (SK-MEL-2), and colon (HCT15) can...