Daniel T. Leung, Taufiqur Rahman Bhuiyan, Naoshin Sharmin Nishat, Mohammad Rubel Hoq et al.
BACKGROUND: Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in abundance in the intestinal mucosa, and are thought to play a role in bridging the innate-adaptive interface. METHODS: We measured MAIT cell frequencies and antibody responses in blood from patients presenting w...
Russell A. Johnson, Taher Uddin, Amena Aktar, M. Mohasin et al.
Immunity against Vibrio cholerae O1 is serogroup specific, and serogrouping is defined by the O-specific polysaccharide (OSP) part of lipopolysaccharide (LPS). Despite this, human immune responses to V. cholerae OSP have not previously been characterized. We assessed immune responses against V. chol...
Sweta Patel, Mohammad Arif Rahman, M. Mohasin, M. Asrafuzzaman Riyadh et al.
Vibrio cholerae O1 causes cholera, a dehydrating diarrheal disease. We have previously shown that V. cholerae-specific memory B cell responses develop after cholera infection, and we hypothesize that these mediate long-term protective immunity against cholera. We prospectively followed household con...
Daniel T. Leung, Mohammad Arif Rahman, M. Mohasin, Sweta Patel et al.
Current oral cholera vaccines induce lower protective efficacy and shorter duration of protection against cholera than wild-type infection provides, and this difference is most pronounced in young children. Despite this, there are limited data comparing immune responses in children following wild-ty...
Amena Aktar, M. Arifur Rahman, Sadia Afrin, Aklima Akter et al.
BACKGROUND: The mediators of protection against cholera, a severe dehydrating illness of humans caused by Vibrio cholerae, are unknown. We have previously shown that plasma IgA as well as memory B IgG cells targeting lipopolysaccharide (LPS) of Vibrio cholerae O1 correlate with protection against V....
Daniel T. Leung, Taher Uddin, Peng Xu, Amena Aktar et al.
Current oral cholera vaccines induce lower levels of protective efficacy and shorter durations of protection in young children than in adults. Immunity against cholera is serogroup specific, and immune responses to Vibrio cholerae lipopolysaccharide (LPS), the antigen that mediates serogroup-specifi...
Daniel T. Leung, Mohammad Arif Rahman, M. Mohasin, M. Asrafuzzaman Riyadh et al.
Children bear a large component of the global burden of cholera. Despite this, little is known about immune responses to cholera in children, especially those under 5 years of age. Cholera vaccine studies have demonstrated lower long-term protective efficacy in young children than in older children ...
Taher Uddin, Amena Aktar, Peng Xu, Russell A. Johnson et al.
Protective immunity to cholera is serogroup specific, and serogrouping is defined by the O-specific polysaccharide (OSP) of lipopolysaccharide (LPS). We characterized OSP-specific immune responses in adult recipients of an oral killed cholera vaccine (OCV WC-rBS) and compared these with responses in...
Arifa Sultana, Saimon Shahriar, Md. Rafat Tahsin, Sabiha Rahman Mim et al.
BACKGROUND: The Oxford-AstraZeneca vaccine (Covishield) was the first to be introduced in Bangladesh to fight the ongoing global COVID-19 pandemic. As this vaccine had shown some side-effects in its clinical trial, we aimed to conduct a study assessing short-term adverse events following immunizatio...
Amena Aktar, M. Arifur Rahman, Sadia Afrin, Md. Omar Faruk et al.
Cholera caused by Vibrio cholerae O1 confers at least 3 to 10 years of protection against subsequent disease regardless of age, despite a relatively rapid fall in antibody levels in peripheral blood, suggesting that memory B cell responses may play an important role in protection. The V. cholerae O1...
Mohammad Murshid Alam, Amena Aktar, Sadia Afrin, Mohammad Arif Rahman et al.
BACKGROUND: Multiple infections with diverse enterotoxigenic E. coli (ETEC) strains lead to broad spectrum protection against ETEC diarrhea. However, the precise mechanism of protection against ETEC infection is still unknown. Therefore, memory B cell responses and affinity maturation of antibodies ...
Ruhul Kayesh, Md Zakir Sultan, A. F. M. Mustafizur Rahman, Md. Gias Uddin et al.
A rapid and highly sensitive reversed phase high performance liquid chromatographic method has been developed for quantitative estimation of omeprazole in pharmaceutical preparations. The method has been validated according to FDA and USP guidelines with respect to accuracy, precision, specificity a...
Mohiuddin Ahmed Bhuiyan, Md. Shamim Reza, Avijit Ghosh, Hmoud Al-Dmour et al.
Fatema Nasrin, Israt Jahan Bulbul, Fahima Aktar, Mohammad A Rashid
This study was carried out to evaluate the anti-inflammatory and antioxidant activities of Cucumis sativus Linn. (Family: Cucurbitaceae) leaves. The methanolic extract of C. sativus leaves (MCS) was investigated for antiinflammatory activities in Long Evans rat model at two different doses of 150 an...
Md. Rafat Tahsin, Tanzia Islam Tithi, Sabiha Rahman Mim, Ehfazul Haque et al.
Background. Diabetes mellitus is one of the most notable health dilemmas. Analyzing plants for new antidiabetic remedies has become an impressive territory for life science researchers. Gynura procumbens has long been used to treat diabetes. Thus, we strived to ascertain the hypoglycemic potentialit...
Md. Rafat Tahsin, Arifa Sultana, Muhammad Shah Mohtasim Khan, Ishrat Jahan et al.
play an important role in its usefulness. This study, therefore, scientifically confirmed the traditional use of this medicinal plant in the management of several diseased conditions.
Tanzia Islam Tithi, Md. Rafat Tahsin, Juhaer Anjum, Tasnuva Sharmin Zaman et al.
INTRODUCTION: The liver, the most important metabolic organ of the body, performs a wide variety of vital functions. Hepatic cell injury occurs by the activation of reactive oxygen species (ROS) that are generated by carbon tetrachloride (CCl4), xenobiotics, and other toxic substances through cytoch...
Noushin Anjum, Md. Jamal Hossain, Fahima Aktar, Mohammad Rashedul Haque et al.
People in Bangladeshi village area have long practice to take plant-based products for their basic health care. Schleichera oleosa (Lour.) Oken (Family: Sapindaceae) is an important folk medicine in Bangladesh, India that has been used to cure a wide variety of human ailments. Here, the crude methan...
Aklima Akter, Pinki Dash, Amena Aktar, Sultana Rownok Jahan et al.
BACKGROUND: Oral cholera vaccine (OCV) containing killed Vibrio cholerae O1 and O139 organisms (Bivalent-OCV; Biv-OCV) are playing a central role in global cholera control strategies. OCV is currently administered in a 2-dose regimen (day 0 and 14). There is a growing body of evidence that immune re...
Fahima Aktar, Md Abul Kaisar, ANM Hamidul Kabir, Choudhury Mahmood Hasan et al.
A total of four compounds namely betulin (1), erythrodiol (2), lupeol (3), and stigmasterol were isolated from the leaf extract of Ixora arborea for the first time. The structures of the isolated compounds were established by extensive spectroscopic studies. In our preliminary screening, the petrole...