Plabon Kumar Das, Farhadul Islam, Alfred K. Lam
Cancer stem cells (CSCs) are the main culprits involved in therapy resistance and disease recurrence in colorectal carcinoma (CRC). Results using cell culture, animal models and tissues from patients with CRC suggest the indispensable roles of colorectal CSCs in therapeutic failure. Conventional the...
Karishma Sajnani, Farhadul Islam, Robert A. Smith, Vinod Gopalan et al.
Cancer cells exhibit alterations in many cellular processes, including oxygen sensing and energy metabolism. Glycolysis in non-oxygen condition is the main energy production process in cancer rather than mitochondrial respiration as in benign cells. Genetic and epigenetic alterations of Krebs cycle ...
Md. Shafiqul Islam, Shamima Nasrin, Muhammad Ali Khan, A.B.M. Sharif Hossain et al.
Abstract Background The use of plants and their derived substances increases day by day for the discovery of therapeutic agents owing to their versatile applications. Current research is directed towards finding naturally-occurring antioxidants having anticancer properties from plant origin since ox...
Plabon Kumar Das, Suja Pillai, Md. Abdur Rakib, Jahan Ara Khanam et al.
In embryonic development and throughout life, there are some cells can exhibit phenotypic plasticity. Phenotypic plasticity is the ability of cells to differentiate into multiple lineages. In normal development, plasticity is highly regulated whereas cancer cells re-activate this dynamic ability for...
Farhadul Islam, Vinod Gopalan, Alfred K. Lam
FAM134B (family with sequence similarity 134, member B)/RETREG1 and its functional roles are relatively new in human diseases. This review aimed to summarize various functions of FAM134B since our first discovery of the gene in 2001. The protein encoded by FAM134B is a reticulophagy receptor that re...
Farhadul Islam, Vinod Gopalan, Jelena Vider, Riajul Wahab et al.
Objectives: The role and underlying mechanism of miR‐186‐5p in colorectal cancer remain unknown. The present study aims to examine the various cellular effects of miR‐186‐5p in the carcinogenesis of colorectal cancer. Also, the interacting targets and association of clinicopathological factors with ...
Md Sohel, Suraiya Aktar, Partha Biswas, Md. Al Amin et al.
BACKGROUND: The most common and deadly cancer in female is breast cancer (BC) and new incidence and deaths related to this cancer are rising. AIMS: Several issues, that is, high cost, toxicity, allergic reactions, less efficacy, multidrug resistance, and the economic cost of conventional anti-cancer...
Plabon Kumar Das, Joti Saha, Suja Pillai, Alfred K. Lam et al.
Estrogens have been implicated in the pathogenesis of various cancer types, including colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular signaling cascades followed by binding to estrogen, resulting in important changes in cellular behaviors. The nuclear estrog...
Farhadul Islam, Hasimah Abdul Rahman, Md. Hasan Ali
Farhadul Islam, Vinod Gopalan, Jelena Vider, Cu‐Tai Lu et al.
OBJECTIVES: miR-142-5p was noted aberrantly expressed and plays important roles in different pathophysiological conditions in human. The present study aims to examine the expression of miR-142-5p and its association with clinicopathological factors in a large cohort of patients with colorectal cance...
Syed Rashel Kabir, Farhadul Islam, A.K.M. Asaduzzaman
Abstract Silver/silver chloride nanoparticles (Ag/AgCl-NPs) were synthesized for the first time from the herbal Geodorum densiflorum rhizome extracts and characterized by different techniques. The surface plasmon resonance peak at 455 nm was observed in the UV–Visible spectrum, the average particle ...
Md Mahbubur Rahman, Ashikul Islam, Farhadul Islam, Mashruba Zaman et al.
Nowadays, Polycystic Ovary Syndrome (PCOS) affects many women, making it a prevalent concern. It is a hormonal disorder that causes irregular, delayed, or absent menstrual cycles in the female body. This condition can lead to the development of type 2 diabetes, gestational diabetes, weight gain, unw...
Polly H. M. Leung, Subramanya Rao, Qianqian Mou, Katherine Ting‐Wei Lee et al.
Colonic microbiota play important roles in the development of colorectal cancer. We aim to characterize the mucosa-associated microbiota in the tumour as well as the matched non-neoplastic mucosa from patients with colorectal cancer. Microbiota profiling in these samples was done using high-throughp...
Syed Rashel Kabir, Md. Amir Hossen, Md. Abu Zubair, Md. Jahangir Alom et al.
A lectin (designated as KRL) was purified from the extracts of Kaempferia rotunda Linn. tuberous rhizome by glucose-sepharose affinity chromatography. KRL was determined to be a 29.0± 1.0 kDa polypeptide by SDS-PAGE under both reducing and non-reducing conditions. KRL was a divalent ion dependent gl...
Hamidreza Maroof, Farhadul Islam, Lan‐Feng Dong, Prabha Ajjikuttira et al.
This study aims to determine the functional roles of microRNA-34b-5p (miR-34b) in the suppression of anaplastic thyroid carcinoma. We used hydration-of-freeze-dried-matrix (HFDM) formulated liposomes (liposome-loaded miR-34b) for effective delivery of miR-34b to anaplastic thyroid carcinoma in vitro...