Kristen N. LeGault, Stephanie G. Hays, Angus Angermeyer, Amelia C. McKitterick et al.
Back to the future phage The interrelationships that prevail between bacteria and their phage parasites are subtle and evolutionarily dynamic. In Bangladesh, cholera remains endemic, and natural, clinically relevant infections have been monitored for decades. LeGault et al . investigated the relatio...
Luisa F. Angeles, Shamim Islam, Jared Aldstadt, Kazi Nazmus Saqeeb et al.
Densely populated countries in Asia, such as Bangladesh, are considered to be major contributors to the increased occurrence of global antimicrobial resistance (AMR). Several factors make low-and middle-income countries vulnerable to increased emergence and spread of AMR in the environment including...
Shirajum Monira, Syeda Antara Shabnam, Sk. Imran Ali, Abdus Sadique et al.
The gut of human harbors diverse commensal microbiota performing an array of beneficial role for the hosts. In the present study, the major commensal gut bacteria isolated by culturing methods from 15 children of moderate income families, aged between 10 and 24 months, were studied for their respons...
Fatema-Tuz Johura, Jarin Tasnim, Indrajeet Barman, Sahitya Ranjan Biswas et al.
Abstract Background One of the most significant public health concerns in today’s world is the persistent upsurge of infections caused by multidrug resistant bacteria. As a result, clinicians are being forced to intervene with either less effective backup drugs or ones with substantial side-effects....
Fatema-Tuz Johura, Rozina Parveen, Atiqul Islam, Abdus Sadique et al.
Shiga-toxin producing Escherichia coli (STEC) and enterotoxigenic E. coli (ETEC) are important causes of diarrhea in humans and animals worldwide. Although ruminant animals are the main source of STEC, diarrhea due to this pathotype is very low in Bangladesh where ETEC remains the predominant group ...
Sameer Dixit, Fatema‐Tuz Johura, Sulochana Manandhar, Abdus Sadique et al.
BACKGROUND: Although endemic cholera causes significant morbidity and mortality each year in Nepal, lack of information about the causal bacterium often hinders cholera intervention and prevention. In 2012, diarrheal outbreaks affected three districts of Nepal with confirmed cases of mortality. This...
Amelia C. McKitterick, Stephanie G. Hays, Fatema‐Tuz Johura, Munirul Alam et al.
Phage defense systems are often found on mobile genetic elements (MGEs), where they constitutively defend against invaders or are induced to respond to new assaults. Phage satellites, one type of MGE, are induced during phage infection to promote their own transmission, reducing phage production and...
Angus Angermeyer, Stephanie G. Hays, Maria Nguyen, Fatema‐Tuz Johura et al.
With 1 to 4 million estimated cases annually, cholera is a disease of serious global concern in regions where access to safe drinking water is limited by inadequate infrastructure, inequity, or natural disaster. The Global Task Force on Cholera Control (GTFCC.org) considers outbreak surveillance to ...
Shah M. Rashed, Shahnewaj Bin Mannan, Fatema-Tuz Johura, Mohammad Tarequl Islam et al.
Vibrio cholerae O1 biotype El Tor (ET), causing the seventh cholera pandemic, was recently replaced in Bangladesh by an altered ET possessing ctxB of the Classical (CL) biotype, which caused the first six cholera pandemics. In the present study, V. cholerae O1 strains associated with endemic cholera...
Munirul Alam, Mohammad Tarequl Islam, Shah M. Rashed, Fatema‐Tuz Johura et al.
Vibrio cholerae O1 classical (CL) biotype caused the fifth and sixth pandemics, and probably the earlier cholera pandemics, before the El Tor (ET) biotype initiated the seventh pandemic in Asia in the 1970s by completely displacing the CL biotype. Although the CL biotype was thought to be extinct in...
Raisa Rafique, Mahamud‐ur Rashid, Shirajum Monira, Zillur Rahman et al.
Recurrent cholera causes significant morbidity and mortality among the growing population of Dhaka, the capital city of Bangladesh. Previous studies have demonstrated that household contacts of cholera patients are at >100 times higher risk of cholera during the week after the presentation of the in...
Christine Marie George, Shirajum Monira, Fatema Zohura, Elizabeth Thomas et al.
BACKGROUND: The Cholera Hospital-Based Intervention for 7 Days (CHoBI7) mobile health (mHealth) program was a cluster-randomized controlled trial of diarrhea patient households conducted in Dhaka, Bangladesh. METHODS: Patients were block-randomized to 3 arms: standard message on oral rehydration sol...
Atiqul Islam, Maurizio Labbate, Steven P. Djordjevic, Munirul Alam et al.
Of the 200+ serogroups of Vibrio cholerae, only O1 or O139 strains are reported to cause cholera, and mostly in endemic regions. Cholera outbreaks elsewhere are considered to be via importation of pathogenic strains. Using established animal models, we show that diverse V. cholerae strains indigenou...
Abdus Sadique, Sucharit Basu Neogi, Tanvir Bashar, Marzia Sultana et al.
Aeromonads are aquatic bacteria associated with frequent outbreaks of diarrhea in coastal Bangladesh, but their potential risks from environmental sources have remained largely unexplored. This study, over 2 years, examined homestead pond waters in the region for monthly dynamics and diversity of Ae...
Daichi Morita, Masatomo Morita, Munirul Alam, Asish K. Mukhopadhyay et al.
Cholera continues to be a global concern, as large epidemics have occurred recently in Haiti, Yemen, and countries of sub-Saharan Africa. A single lineage of Vibrio cholerae O1 has been considered to be introduced into these regions from South Asia and to cause the spread of cholera. Using genomic e...