Samarasimha Reddy N, Nayana P. Nair, Jacqueline E. Tate, Varunkumar Thiyagarajan et al.
BACKGROUND: A three-dose, oral rotavirus vaccine (Rotavac) was introduced in the universal immunization program in India in 2016. A prelicensure trial involving 6799 infants was not large enough to detect a small increased risk of intussusception. Postmarketing surveillance data would be useful in a...
Clint Pecenka, Umesh D. Parashar, Jacqueline E. Tate, Jahangir Khan et al.
INTRODUCTION: Diarrheal disease is a leading cause of child mortality globally, and rotavirus is responsible for more than a third of those deaths. Despite substantial decreases, the number of rotavirus deaths in children under five was 215,000 per year in 2013. Of these deaths, approximately 41% oc...
Eleanor Burnett, Furqan Kabir, Nguyễn Vân Trang, Ajit Rayamajhi et al.
BACKGROUND: The etiology of intussusception, the leading cause of bowel obstruction in infants, is unknown in most cases. Adenovirus has been associated with intussusception and slightly increased risk of intussusception with rotavirus vaccination has been found. We conducted a case-control study am...
Sayem Ahmed, Farzana Dorin, Syed M Satter, Abdur Razzaque Sarker et al.
Background: Rotavirus is a common cause of severe acute gastroenteritis among young children. Estimation of the economic burden would provide informed decision about vaccine investment, which has been a potential policy discussion in Bangladesh for several years. Methods: We estimated the societal c...
Daniel A. Salmon, P H Lambert, Hanna Nohynek, Julianne Gee et al.
Vaccine licensure requires a very high safety standard and vaccines routinely used are very safe. Vaccine safety monitoring prelicensure and postlicensure enables continual assessment to ensure the benefits outweigh the risks and, when safety problems arise, they are quickly identified, characterise...
Eleanor Burnett, Nguyễn Vân Trang, Ajit Rayamajhi, Mohammad Tahir Yousafzai et al.
Intussusception is the invagination of one segment of the bowel into a distal segment, characterized by symptoms of bloody stool, vomiting, and abdominal pain. Previous studies have found regional differences in incidence but the etiology of most intussusception cases is unknown. Rotavirus vaccines ...
Jordan Cates, Helen Powell, James A Platts-Mills, Dilruba Nasrin et al.
BACKGROUND: Quantitative molecular assays are increasingly used for detection of enteric viruses. METHODS: We compared the clinical severity using the modified Vesikari score (mVS) of enteric viruses detected by conventional assays (enzyme immunoassays [EIAs] for rotavirus and adenovirus 40/41 and c...
Mary Carol Jennings, Molly Sauer, Chloe Manchester, Heidi M. Soeters et al.
Despite the 2009 World Health Organization recommendation that all countries introduce rotavirus vaccines (RVV) into their national immunization programs, just 81 countries had introduced RVV by the end of 2015, leaving millions of children at risk for rotavirus morbidity and mortality. In response,...
Jordan Cates, Jacqueline E. Tate, Umesh D. Parashar, Sara Mirza et al.
Abstract Background Viruses are a leading cause of pediatric diarrheal illness, resulting in over 200,000 childhood deaths annually worldwide. Rotavirus is the most common viral cause of moderate-to-severe diarrhea in low to middle-income countries, but adenovirus 40/41, norovirus, sapovirus, and as...
M. J. Whelton, Patricia Fitzgerald, Ellen K. Ritchie, D. Jenkins et al.