Michael Hoffmann, Craig Hilton‐Taylor, Ariadne Angulo, Monika Böhm et al.
Assessing Biodiversity Declines Understanding human impact on biodiversity depends on sound quantitative projection. Pereira et al. (p. 1496 , published online 26 October) review quantitative scenarios that have been developed for four main areas of concern: species extinctions, species abundances a...
CARDIoGRAMplusC4D, Joanna M. M. Howson, EPIC-CVD, Wei Zhao et al.
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may...
Rebecca Milton, David Gillespie, Calie Dyer, Khadijeh Taiyari et al.
BACKGROUND: Neonatal sepsis is a primary cause of neonatal mortality and is an urgent global health concern, especially within low-income and middle-income countries (LMICs), where 99% of global neonatal mortality occurs. The aims of this study were to determine the incidence and associations with n...
Cornelius F. Boerkoel, Sinéad M. O’Neill, Jean Luc André, P.J. Benke et al.
Unlabelled Schimke immuno-osseous dysplasia (SIOD) is a rare autosomal recessive spondylo-epiphyseal dysplasia. The characteristic features of SIOD include 1) short stature with hyperpigmented macules and an unusual facies, 2) proteinuria with progressive renal failure, 3) lymphopenia with recurrent...
Petter Brodin, Giorgio Casari, Liam Townsend, Cliona O’Farrelly et al.
Se Eun Park, Duy Pham Thanh, Christine J. Boinett, Vanessa Wong et al.
There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 s...
Kathryn Thomson, Calie Dyer, Feiyan Liu, Kirsty Sands et al.
BACKGROUND: Sepsis is a major contributor to neonatal mortality, particularly in low-income and middle-income countries (LMICs). WHO advocates ampicillin-gentamicin as first-line therapy for the management of neonatal sepsis. In the BARNARDS observational cohort study of neonatal sepsis and antimicr...
Axel Bruns, Anja Bechmann, Jean Burgess, Andrew Chadwick et al.
In reaction to the Cambridge Analytica controversy, Facebook has recently announced a substantial tightening of access restrictions to the APIs of Facebook, Instagram, and other platforms it owns. Researchers at leading international research organisations are deeply concerned about collateral impac...
Mieke Soens, Jintanat Ananworanich, Bryony Hicks, Kathryn Jean Lucas et al.
Messenger RNA (mRNA)-based influenza vaccines have the potential to improve upon limitations of current vaccine approaches to seasonal influenza. Here we report findings on the primary and secondary objectives of the safety, reactogenicity, and humoral immunogenicity of the quadrivalent mRNA vaccine...
Habib Md Reazaul Karim, Karen E. A. Burns, Laura Ciobanu, Mohamad F. El‐Khatib et al.
Noninvasive ventilation (NIV) is an increasingly used method of respiratory support. The use of NIV is expanding over the time and if properly applied, it can save patients' lives and improve long-term prognosis. However, both knowledge and skills of its proper use as life support are paramount. Thi...
Maria Nieto, Kirsty Sands, Edward Portal, Kathryn Thomson et al.
Abstract Hospital surfaces can harbour bacterial pathogens, which may disseminate and cause nosocomial infections, contributing towards mortality in low- and middle-income countries (LMICs). During the BARNARDS study, hospital surfaces from neonatal wards were sampled to assess the degree of environ...
Kirsty Sands, Maria J. Carvalho, O. Brad Spiller, Edward Portal et al.
BACKGROUND: In low- and middle-income countries (LMIC) Staphylococcus aureus is regarded as one of the leading bacterial causes of neonatal sepsis, however there is limited knowledge on the species diversity and antimicrobial resistance caused by Gram-positive bacteria (GPB). METHODS: We characteris...
Jorge Martínez-Vázquez, François Vaillancourt
Contents: 1. An Overview of the Main Obstacles to Decentralization Jorge Martinez-Vazquez and Francois Vaillancourt 2. Conceptual Problems in the Assignment of Functions in SEE: The Case of Albania Bernard Dafflon 3. Decentralization in the Post-Conflict African Environment: Sierra Leone and Souther...
Samuel Arends, Judith Drenthen, Peter Van den Bergh, Hessel Franssen et al.
OBJECTIVE: To describe the heterogeneity of electrodiagnostic (EDx) studies in Guillain-Barré syndrome (GBS) patients collected as part of the International GBS Outcome Study (IGOS). METHODS: Prospectively collected clinical and EDx data were available in 957 IGOS patients from 115 centers. Only the...
Leopoldo Cavaleri Gerhardinger, Tanya Brodie Rudolph, Françoise Gaill, P. Graham Mortyn et al.
The efficacy of global environmental assessments in informing and shaping ocean and coastal management is hampered by recognized gaps in global science endeavours. In order to bridge these gaps, and secure inclusive and equitable knowledge co-construction by ocean stakeholders, the International Pan...