Shiv Kumar Sarin, Manoj Kumar, George Lau, Zaigham Abbas et al.
Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available ...
John L. Wilkinson, Alistair B.A. Boxall, Dana W. Kolpin, Kmy Leung et al.
Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the ...
Shiv Kumar Sarin, Ashok Choudhury, Manoj K. Sharma, Rakhi Maiwall et al.
The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set up in 2004 on acute-on-chronic liver failure (ACLF) was published in 2009. With international groups volunteering to join, the “APASL ACLF Research Consortium (AARC)” was formed in...
Taotao Li, Wei Guo, Liang Ma, Weisheng Li et al.
Two-dimensional (2D) semiconductors, in particular transition metal dichalcogenides (TMDCs), have attracted great interest in extending Moore's law beyond silicon 1-3 . However, despite extensive efforts 4-25 , the growth of wafer-scale TMDC single crystals on scalable and industry-compatible substr...
Shuaihua Lu, Qionghua Zhou, Yixin Ouyang, Yilv Guo et al.
Rapidly discovering functional materials remains an open challenge because the traditional trial-and-error methods are usually inefficient especially when thousands of candidates are treated. Here, we develop a target-driven method to predict undiscovered hybrid organic-inorganic perovskites (HOIPs)...
Derek Klarin, The VA Million Veteran Program, Scott M. Damrauer, Kelly Cho et al.
The Million Veteran Program (MVP) was established in 2011 as a national research initiative to determine how genetic variation influences the health of US military veterans. Here we genotyped 312,571 MVP participants using a custom biobank array and linked the genetic data to laboratory and clinical...
Eddy van Doorslaer, Owen O’Donnell, Ravindra P. Rannan‐Eliya, Aparnaa Somanathan et al.
Out-of-pocket (OOP) payments are the principal means of financing health care throughout much of Asia. We estimate the magnitude and distribution of OOP payments for health care in fourteen countries and territories accounting for 81% of the Asian population. We focus on payments that are catastroph...
Zhaoyan Luo, Yixin Ouyang, Hao Zhang, Meiling Xiao et al.
Abstract Lacking strategies to simultaneously address the intrinsic activity, site density, electrical transport, and stability problems of chalcogels is restricting their application in catalytic hydrogen production. Herein, we resolve these challenges concurrently through chemically activating the...
Weisheng Li, Xiaoshu Gong, Zhihao Yu, Liang Ma et al.
The development of next-generation electronics requires scaling of channel material thickness down to the two-dimensional limit while maintaining ultralow contact resistance 1,2 . Transition-metal dichalcogenides can sustain transistor scaling to the end of roadmap, but despite a myriad of efforts, ...
Paolo Zanoni, Sumeet A. Khetarpal, Daniel B. Larach, William Hancock‐Cerutti et al.
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL-C l...
Justina X. Caushi, Jiajia Zhang, Zhicheng Ji, Ajay Vaghasia et al.
Abstract PD-1 blockade unleashes CD8 T cells 1 , including those specific for mutation-associated neoantigens (MANA), but factors in the tumour microenvironment can inhibit these T cell responses. Single-cell transcriptomics have revealed global T cell dysfunction programs in tumour-infiltrating lym...
Jing Meng, Zhifu Mi, Dabo Guan, Jiashuo Li et al.
Abstract Economic globalization and concomitant growth in international trade since the late 1990s have profoundly reorganized global production activities and related CO 2 emissions. Here we show trade among developing nations (i.e., South–South trade) has more than doubled between 2004 and 2011, w...
Lei Liu, Taotao Li, Liang Ma, Weisheng Li et al.
Two-dimensional transition-metal dichalcogenides (TMDs) are of interest for beyond-silicon electronics 1,2 . It has been suggested that bilayer TMDs, which combine good electrostatic control, smaller bandgap and higher mobility than monolayers, could potentially provide improvements in the energy-de...
Georg Ehret, Teresa Ferreira, Daniel I. Chasman, Anne Jackson et al.
To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 ...
Jianquan Lu, Daniel W. C. Ho, Jinde Cao, Jürgen Kurths
This brief investigates globally exponential synchronization for linearly coupled neural networks (NNs) with time-varying delay and impulsive disturbances. Since the impulsive effects discussed in this brief are regarded as disturbances, the impulses should not happen too frequently. The concept of ...
Qing Li, Yong Ni, Liren Zhang, Runqiu Jiang et al.
N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy activation is one of the ways by which cancer cells survive hypoxia. However, the possible involvement of m6A modification of mRNA in hypox...
Norihiro Kato, CARDIo GRAMplusCD, LifeLines Cohort Study, Marie Loh et al.
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to 5.0 × 10−21). ...
Xuping Song, Shigong Wang, Yuling Hu, Man Yue et al.
The objectives were (i) to conduct an overview of systematic reviews to summarize evidence from and evaluate the methodological quality of systematic reviews assessing the impact of ambient temperature on morbidity and mortality; and (ii) to reanalyse meta-analyses of cold-induced cardiovascular mor...
Shengjie Peng, Guorui Jin, Linlin Li, Kai Li et al.
Tissue regeneration, energy conversion & storage, and water treatment are some of the most critical challenges facing humanity in the 21st century. In order to address such challenges, one-dimensional (1D) materials are projected to play a key role in developing emerging solutions for the increasing...
Quan Zhang, Tao Jin, Jianguo Cai, Liang Xu et al.
Gait and waist motions always contain massive personnel information and it is feasible to extract these data via wearable electronics for identification and healthcare based on the Internet of Things (IoT). There also remains a demand to develop a cost-effective human-machine interface to enhance th...