Jorge Alvar, Iván Darío Vélez, Caryn Bern, Mercè Herrero et al.
As part of a World Health Organization-led effort to update the empirical evidence base for the leishmaniases, national experts provided leishmaniasis case data for the last 5 years and information regarding treatment and control in their respective countries and a comprehensive literature review wa...
Richard J. Whittington, Karsten Donat, M.F. Weber, D.F. Kelton et al.
Paratuberculosis, a chronic disease affecting ruminant livestock, is caused by Mycobacterium avium subsp. paratuberculosis (MAP). It has direct and indirect economic costs, impacts animal welfare and arouses public health concerns. In a survey of 48 countries we found paratuberculosis to be very com...
Francesco María Sabatini, Borja Jiménez‐Alfaro, Ute Jandt, Milan Chytrý et al.
Global patterns of regional (gamma) plant diversity are relatively well known, but whether these patterns hold for local communities, and the dependence on spatial grain, remain controversial. Using data on 170,272 georeferenced local plant assemblages, we created global maps of alpha diversity (loc...
Suman Rijal, Shyam Sundar, Dinesh Mondal, Pradeep Das et al.
\nSuman Rijal and colleagues highlight lessons from a regional collaboration to eliminate visceral leishmaniasis and identify priorities for the post-elimination plan
Dinesh Mondal, Caryn Bern, Debashis Ghosh, Masud Rashid et al.
BACKGROUND: On the Indian subcontinent, visceral leishmaniasis (VL) incidence is on track to reach elimination goals by 2020 in nearly all endemic districts. Although not included in official targets, previous data suggest post-kala-azar dermal leishmaniasis (PKDL) patients can act as an infection r...
Pieter A. Zuidema, Flurin Babst, Peter Groenendijk, Valérie Trouet et al.
Matthew Reynolds, A.J.D. Pask, William Hoppitt, Kai Sonder et al.
Abstract To accelerate genetic gains in breeding, physiological trait (PT) characterization of candidate parents can help make more strategic crosses, increasing the probability of accumulating favorable alleles compared to crossing relatively uncharacterized lines. In this study, crosses were desig...
Greg Matlashewski, Byron Arana, Axel Kroeger, S. Battacharya et al.
The world's burden of infectious diseases can be substantially reduced by more-effective use of existing interventions. Advances in case detection, diagnosis, and treatment strategies have made it possible to consider the elimination of visceral leishmaniasis in the Indian subcontinent. The priority...
Anand Joshi, J P Narain, C Prasittisuk, Rajesh Bhatia et al.
Data on the burden of visceral leishmaniasis (VL) in Indian sub-continent are vital for elimination programme planners for estimating resource requirements, effective implementation and monitoring of elimination programme. In Indian sub-continent, about 200 million population is at risk of VL. Nearl...
Ridwanur Rahman, Vishal Goyal, Rashidul Haque, Kazi M. Jamil et al.
BACKGROUND: AmBisome therapy for VL has an excellent efficacy and safety profile and has been adopted as a first-line regimen in Bangladesh. Second-line treatment options are limited and should preferably be given in short course combinations in order to prevent the development of resistant strains....
Ricardo Molina, Debashis Ghosh, Eugenia Carrillo, Séverine Monnerat et al.
We compared xenodiagnosis with quantitative polymerase chain reaction in skin biopsies from 3 patients with maculopapular or nodular post-kala-azar dermal leishmaniasis (PKDL). All patients infected sand flies. Parasite loads in skin varied from 1428 to 63 058 parasites per microgram. PKDL detection...
Dinesh Mondal, Jorge Alvar, Md Golam Hasnain, Md Shakhawat Hossain et al.
BACKGROUND: To rapidly reduce the burden of visceral leishmaniasis for national elimination programmes, an acceptable, safe, and effective treatment is needed that can be delivered at primary health-care centres. We aimed to assess the tolerability, safety, and cure rate of single-dose liposomal amp...
Rajib Chowdhury, Dinesh Mondal, Vashkar Chowdhury, Shyla Faria et al.
INTRODUCTION: In 2005, Bangladesh, India, and Nepal joined forces to eliminate Visceral Leishmaniasis (or kala-azar) from the region by 2015. In Bangladesh the elimination target is set at less than one new case per 10,000 population per year at upazila (sub-district) level. As the deadline approach...
Tari Haahtela, Leena von Hertzen, Josep M Antó, Chunxue Bai et al.
BACKGROUND: was the overarching theme of the 12th General Meeting of the Global Alliance against Chronic Respiratory Diseases (GARD) in Helsinki, August 2018. New approaches are needed to improve respiratory health and reduce premature mortality of chronic diseases by 30% till 2030 (UN Sustainable D...
Jeppe Thagaard, Glenn Broeckx, David B. Page, Chowdhury Arif Jahangir et al.
The clinical significance of the tumor-immune interaction in breast cancer is now established, and tumor-infiltrating lymphocytes (TILs) have emerged as predictive and prognostic biomarkers for patients with triple-negative (estrogen receptor, progesterone receptor, and HER2-negative) breast cancer ...