Journal ArticleOpen Access
Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent
Authors
Author Affiliations
Instituto de Salud Carlos III, International Centre for Diarrhoeal Disease Research, Drugs for Neglected Diseases Initiative, University of California, San Francisco
Published InClinical Infectious Diseases
Year2017
Citations71
Abstract
We compared xenodiagnosis with quantitative polymerase chain reaction in skin biopsies from 3 patients with maculopapular or nodular post-kala-azar dermal leishmaniasis (PKDL). All patients infected sand flies. Parasite loads in skin varied from 1428 to 63 058 parasites per microgram. PKDL detection and treatment are important missing components of the kala-azar elimination program.
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