Saifon Chawanpaiboon, Joshua P. Vogel, Ann‐Beth Moller, Pisake Lumbiganon et al.
BACKGROUND: Preterm birth is the leading cause of death in children younger than 5 years worldwide. Although preterm survival rates have increased in high-income countries, preterm newborns still die because of a lack of adequate newborn care in many low-income and middle-income countries. We estima...
Anne CC Lee, Joanne Katz, Hannah Blencowe, Simon Cousens et al.
BACKGROUND: National estimates for the numbers of babies born small for gestational age and the comorbidity with preterm birth are unavailable. We aimed to estimate the prevalence of term and preterm babies born small for gestational age (term-SGA and preterm-SGA), and the relation to low birthweigh...
Justina X. Caushi, Jiajia Zhang, Zhicheng Ji, Ajay Vaghasia et al.
Abstract PD-1 blockade unleashes CD8 T cells 1 , including those specific for mutation-associated neoantigens (MANA), but factors in the tumour microenvironment can inhibit these T cell responses. Single-cell transcriptomics have revealed global T cell dysfunction programs in tumour-infiltrating lym...
Sarah G. Moxon, Harriet Ruysen, Kate Kerber, Agbessi Amouzou et al.
BACKGROUND: The Every Newborn Action Plan (ENAP), launched in 2014, aims to end preventable newborn deaths and stillbirths, with national targets of ≤12 neonatal deaths per 1000 live births and ≤12 stillbirths per 1000 total births by 2030. This requires ambitious improvement of the data on care at ...
Christine L. Roberts, Tanya Nippita
Historically, the introduction of caesarean section surgery was associated with an improvement in maternal and perinatal health outcomes. WHO has stated that no empirical evidence exists for an ideal caesarean rate, but “what matters most is that all women who need caesarean sections actually receiv...
Caroline Homer, Sabera Turkmani, Alyce N. Wilson, Joshua P. Vogel et al.
INTRODUCTION: Women and children bear a substantial burden of the impact of conflict and instability. The number of people living in humanitarian and fragile settings (HFS) has increased significantly over the last decade. The provision of essential maternal and newborn healthcare by midwives is cru...
Samia Aziz, Abdul Basit, Saima Sultana, Caroline Homer et al.
Postnatal care (PNC) is an essential component of maternity care. Appropriate and timely care immediately after childbirth can save lives and help to prevent or treat comorbidities resulting from pregnancy and childbirth. Despite its importance, PNC coverage is still low in Bangladesh. The aim of th...
Katherine E. Eddy, Joshua P. Vogel, Nick Scott, Dagnachew Fetene et al.
BACKGROUND: After considerable debate, there is now unequivocal evidence that use of antenatal corticosteroids improves outcomes in preterm neonates when used in women at risk of early preterm birth in reasonably equipped hospitals in low-resource countries. We aimed to evaluate the cost-effectivene...
Olufemi T. Oladapo, Joshua P. Vogel, Gilda Piaggio, My Huong Nguyen et al.
Background: The WHO ACTION-I trial demonstrated that dexamethasone significantly reduced neonatal mortality when administered to women at risk of early preterm birth in low-resource countries. We conducted a secondary analysis to determine how these benefits can be optimised, by evaluating the effec...
WHO ACTION Trials Collaborators, Temitope Adesiji Adegboyega, Ebunoluwa A. Adejuyigbe, Olubukola Adesina et al.
BACKGROUND: Preterm birth complications are the leading cause of newborn and under-5 mortality. Over 85% of all preterm births occur in the late preterm period, i.e. between 34 and < 37 weeks of gestation. Antenatal corticosteroids (ACS) prevent mortality and respiratory morbidity when administered ...
Saima Sultana, Joshua P. Vogel, Olufemi T. Oladapo
Preterm birth is defined by the World Health Organization (WHO) as a birth before 37 completed weeks of gestation or fewer than 259 days since the first day of a woman's last menstrual period.1 Globally, preterm birth is estimated to affect 10.6% (95% CI 9.0–12.0) of all pregnant women, equating to ...
Temitope Adesiji Adegboyega, Ebunoluwa A. Adejuyigbe, Olubukola Adesina, Babalola Adeyemi et al.
Background: Preterm birth complications are the leading cause of newborn and under-5 mortality. Over 85% of all preterm births occur in the late preterm period i.e., between 34 and Methods: WHO ACTION III trial is a parallel-group, three-arm, individually randomized, double-blind, placebo-controlled...
Saima Sultana, Iffat Ara Jaben, Tamsasul Farha, Roy Sk et al.
Background The WHO ACTION-I trial in 2020 demonstrated the short-term efficacy and safety of antenatal dexamethasone for women at risk of early preterm birth in low-resource settings. However, the long-term effects of antenatal corticosteroids remain unclear, and no long-term follow-up studies have ...