Monika Böhm, Ben Collen, Jonathan Baillie, Philip Bowles et al.
Effective and targeted conservation action requires detailed information about species, their distribution, systematics and ecology as well as the distribution of threat processes which affect them. Knowledge of reptilian diversity remains surprisingly disparate, and innovative means of gaining rapi...
Tianjie Lei, Jie Feng, Juan Lv, Jiabao Wang et al.
Drought is one of the most prominent natural threats to grassland productivity, although the magnitude of this threat is uncertain due to the different drought-levels. However, drought-productivity dynamics has not yet received much attention. It is necessary to establish the method to evaluate quan...
María Carmen Mulero, Dolors Ferrés-Marcó, Abul Bashar Mir Md. Khademul Islam, Pol Margalef et al.
IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of HOX and IRX genes. Chromatin-bound IκBα modulates Polycomb recruitment and imp...
Juan Shi, Qunhui Wang, Xiang Wei, Bo Huo et al.
BACKGROUND: E1A-associated 300-kDa protein (P300), an endogenous histone acetyltransferase, contributes to modifications of the chromatin landscape of genes involved in multiple cardiovascular diseases. Ferroptosis of vascular smooth muscle cells (VSMCs) is a novel pathological mechanism of aortic d...
Rui Yang, Qiusha Tang, Fengqin Miao, Yanli An et al.
PURPOSE: To explore the thermoresistance and expression of heat-shock protein 90 (HSP90) in magnetic hyperthermia-treated human liver cancer stem-like cells (LCSCs) and the effects of a heat-shock protein HSP90 inhibitor 17-allylamino-17-demethoxgeldanamycin (17-AAG) on hepatocellular carcinoma-burd...
Xu Guan, Zheng Liu, Amjad Parvaiz, Antonio Longo et al.
At present, natural orifice specimen extraction surgery (NOSES) has attracted more and more attention worldwide, because of its great advantages including minimal cutaneous trauma and post-operative pain, fast post-operative recovery, short hospital stay, and positive psychological impact. However, ...
Yi‐Juan Chen, Fanyue Meng, Qunying Mao, Jingxin Li et al.
The demonstration of batch-to-batch consistency to confirm the reliability of the manufacturing process has become a mandatory step in vaccine development. This is a post-hoc analysis aimed to provide more solid evidence on the immunogenicity and consistency of 3 consecutive batches of a novel inact...
Lijuan Li, Li Dong, Jinbo Xie, Yanli Tang et al.
Abstract The Grid‐point Atmospheric Model of the IAP LASG version 3 (GAMIL3) has been developed by upgrading the horizontal resolution, methods of parallel computation, boundary layer scheme, aerosol parameterization, convective parameterization, stratocumulus cloud fraction scheme, land component, ...
Lei Li, Ya-juan Cui, Yu Liu, Huixin Li et al.
Moderate autophagy can remove damaged proteins and organelles. In some inflammatory diseases, autophagy plays a protective role by inhibiting the NOD-like receptor family pyrin domain containing 3(NLRP3). (Pro)renin receptor (PRR, or ATP6AP2) is a critical component of the V-ATPase required for auto...
Lulu Han, Yutong Miao, Yang Zhao, Xingzhong Zhang et al.
Hyperhomocysteinemia (HHcy) is associated with an exaggerated platelet thrombotic response at sites of vascular injury. In this study, human medical examination showed that elevated human plasma Hcy levels correlated positively with enhanced blood coagulation and platelet activity, suggesting that h...
Juan Feng, Jianlei Zhu, Yan Li
Abstract The influence of El Niño on aerosol concentrations is investigated for eastern China over period 1986–2006. Result suggests that the influence of El Niño on aerosol concentration differs between events. The 1987/1988 El Niño event decreased the aerosol concentrations during the mature and d...
Yan Li, Baisheng Ma, Juan Feng, Yao Lü
The impact of the strongest central Pacific (CP) El Niño event 2009/2010 and CP La Niña event 1998/1999 from 1979 to 2010 on the precipitation in eastern China has been analysed. During the 2009/2010 CP El Niño event, it is rainy in northern China during maturing winter and decaying spring, but dry ...
Fei Zhuang, Xin Shi, Sen Qiao, Bin Liu et al.
Allicin exhibits various pharmacological activities and has been suggested to be beneficial in the treatment of stroke. However, the underlying mechanisms are largely unknown. Here, we confirmed that allicin protected the brain from cerebral injury, which could be ascribed to its anti‑apoptotic and ...
Feng Shi, Hugues Goosse, Jianping Li, Qiuzhen Yin et al.
Abstract The East Asian summer monsoon (EASM) plays a crucial role for ecosystems and societies in East Asia past, present, and future. However, substantial uncertainties remain regarding EASM variability on interdecadal to multidecadal timescales because of the short length of instrumental data in ...
Shiyi Tan, Yan Ding, Wei Wang, Jianhua Rao et al.
AI image processing techniques hold promise for clinical applications by enabling analysis of complex status information from cells. Importantly, real-time brightfield imaging has advantages of informativeness, non-destructive nature, and low cost over fluorescence imaging. Currently, human liver or...
Feng Jiang, Xucai Pu, Bernhard Schmid, Peter B. Reich et al.
Unraveling the mechanisms underlying the maintenance of species diversity is a central pursuit in ecology. It has been hypothesized that ectomycorrhizal (EcM) in contrast to arbuscular mycorrhizal fungi can reduce tree species diversity in local communities, which remains to be tested at the global ...
Shuning Yu, Shaoling Li, Zhixin Xie, Wei Liu et al.
Abstract Three new pyrrolo[3,2‐b]pyrrole derivatives containing methoxyphenyl, pyrene or tetraphenylethylene (TPE) units (compounds 1 – 3) have been designed, synthesized and fully characterized. The aggregation‐induced emission (AIE) properties of compounds 1 – 3 were tested in different water frac...
Siyue Jia, Yuanbao Liu, Qian He, Hongxing Pan et al.
We conducted a multicenter, partially randomized, platform trial to assess the effectiveness of a booster dose of an aerosolized or intramuscular adenovirus type 5 vectored COVID-19 vaccine (Ad5-nCoV) in Chinese adults (NCT05855408). Between May 23, 2023, and August 28, 2023, 4089 eligible participa...
Yi bo Jiang, Li Juan Chen, Yaoliang Tang, Gen Shan Ma et al.
OBJECTIVE: To observe the effect of intracoronary transfer of autologous HO-1 overexpressed MSCs in porcine model of myocardial ischemia (1 h)/reperfusion. METHODS: Apoptosis was assayed and cytokine concentrations in supernatant were measured in cells exposed to hypoxia-reoxygen in vitro. In vivo, ...
Yu Yan, Xingyu Feng, Zhiyong Liu, Zizhao Wang et al.
Forest management influences key ecosystem services essential for societal well-being. However, how these human management activities affect forest resilience under different environmental conditions remains poorly understood. This study investigates how different forest management practices interac...