Carol A. Gilchrist, Sarah E. Petri, Brittany N. Schneider, Daniel Reichman et al.
BACKGROUND: An estimated 1 million children die each year before their fifth birthday from diarrhea. Previous population-based surveys of pediatric diarrheal diseases have identified the protozoan parasite Entamoeba histolytica, the etiological agent of amebiasis, as one of the causes of moderate-to...
Kôji Watanabe, Carol A. Gilchrist, Md. Jashim Uddin, Stacey L. Burgess et al.
The disease severity of Entamoeba histolytica infection ranges from asymptomatic to life-threatening. Recent human and animal data implicate the gut microbiome as a modifier of E. histolytica virulence. Here we have explored the association of the microbiome with susceptibility to amebiasis in infan...
Ryoko Taniguchi, Toshio Kumai, Naoki Matsumoto, Minoru Watanabe et al.
Paclitaxel is widely used for treatment of malignant tumors. Paclitaxel is metabolized by CYP2C8 and CYP3A4, and these enzymes are known to differ between individuals, although the details have not been clarified. Recent progress in pharmacogenetics has shown that genetic polymorphisms of metabolic ...
Renay Ngobeni, Amidou Samie, Shannon Moonah, Koji Watanabe et al.
Background: Diarrhea is frequent in communities without clean water, which include low-income South African populations in Giyani and Pretoria. In these populations, the amount of diarrhea caused by Entamoeba histolytica, inclusive of all ages, sexes, and human immunodeficiency virus status, is unce...
Stacey L. Burgess, Jhansi L. Leslie, Md. Jashim Uddin, David N Oakland et al.
The microbiome provides resistance to infection. However, the underlying mechanisms are poorly understood. We demonstrate that colonization with the intestinal bacterium Clostridium scindens protects from Entamoeba histolytica colitis via innate immunity. Introduction of C. scindens into the gut mic...
Genevieve L. Wojcik, Chelsea Marie, Mayuresh M. Abhyankar, Nobuya Yoshida et al.
Diarrhea is the second leading cause of death for children globally, causing 760,000 deaths each year in children less than 5 years old. Amebic dysentery contributes significantly to this burden, especially in developing countries. The identification of host factors that control or enable enteric pa...
Stacey L. Burgess, Jhansi L. Leslie, Md. Jashim Uddin, David N Oakland et al.
Abstract The gut microbiome provides resistance to infection. However, the mechanisms for this are poorly understood. Colonization with the intestinal bacterium Clostridium scindens provided protection from the parasite Entamoeba histolytica via innate immunity. Introduction of C. scindens into the ...
Mohammad Musharraf Uddin Bhuiyan, Yo Suzuki, Hiroyuki Watanabe, Eunsong Lee et al.
The objectives of this study were to choose an effective embryo reconstruction method and an effective post-activation agent for in vitro production of sei whale (Balaenoptera borealis) interspecies somatic cell nuclear transfer (iSCNT) embryos. Moreover, trichostatin A (TSA) treatment of whale iSCN...
Masaharu Fujita, Yusuke Yamamoto, Shinichi Watanabe, Tsunetsugu Sugawara et al.
The amino acid derivative reactivity assay (ADRA) is an in chemico alternative method that focuses on protein binding as the molecular initiating event for skin sensitization. It is a simple and versatile method that has successfully solved some of the problems of the direct peptide reactivity assay...
正子 石井, 尚美 細田, 昌樹 松尾, 功二 堀拔
Acknowledgements Notes on Editors Introduction: Socioeconomic Spaces and Migrants' Lives in the Arab Gulf States Masaki Matsuo, Naomi Hosoda, Koji Horinuki and Masako Ishii Part 1: Migration Policy and the Relationship between Nationals and Migrant Workers 1 International Labor Migration and the Ara...
Renay Ngobeni, Amidou Samie, Shannon Moonah, Kôji Watanabe et al.
Background: Diarrhea is frequent in communities without clean water which include S. African rural Giyani and low-income Pretoria populations. The proportion of diarrhea caused by the Entamoeba histolytica parasite in these populations inclusive of all ages, sexes and HIV status is uncertain. Infect...
Genevieve L. Wojcik, Chelsea Marie, Mayuresh M. Abhyankar, Nobuya Yoshida et al.
Abstract Diarrhea is the second leading cause of death for children globally, causing 760,000 deaths each year in children under the age of 5. Amoebic dysentery contributes significantly to this burden, especially in developing countries. We hypothesize that genetic variation contributes to suscepti...
Aarti Gupta, Yasuko Watanabe, Chien Van Ha, Mostafa Abdelrahman et al.
Amy Trubek
I will confess to having a sweet tooth. Another confession: I have no idea as to the origin of this phrase. Is it original to the English language? Or is it a translation, given the universal human preference for sweet tastes, a desire so established that babies around the world will smile when fed ...