Shamima Akter, Depro Das, Rakib Ul Haque, Mahafujul Islam Quadery Tonmoy et al.
Alzheimer's disease (AD) is the leading cause of dementia globally, with a growing morbidity burden that may exceed diagnosis and management capabilities. The situation worsens when AD patient fatalities are exposed to COVID-19. Because of differences in clinical features and patient condition, a pa...
Atqiya Fariha, Ithmam Hami, Mahafujul Islam Quadery Tonmoy, Shahana Akter et al.
Lung cancer is the primary cause of cancer related deaths worldwide. Limited therapeutic options and resistance to existing drugs are the major hindrances to the clinical success of this cancer. In the past decade, several studies showed the role of microRNA (miRNA) driven cell cycle regulation in l...
Shamima Akter, Arpita Singha Roy, Mahafujul Islam Quadery Tonmoy, Md. Sajedul Islam
gene can help to recognize severe illness due to COVID 19 and consequently assist to develop an effective drug against the infection.Communicated by Ramaswamy H. Sarma.
Md. Shahadat Hossain, A. Q. M. Sala Uddin Pathan, Md Nur Islam, Mahafujul Islam Quadery Tonmoy et al.
Genomic data analysis is a fundamental system for monitoring pathogen evolution and the outbreak of infectious diseases. Based on bioinformatics and deep learning, this study was designed to identify the genomic variability of SARS-CoV-2 worldwide and predict the impending mutation rate. Analysis of...
Md. Shahadat Hossain, Mahafujul Islam Quadery Tonmoy, Atqiya Fariha, Md. Sajedul Islam et al.
A new strain of the beta coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is solely responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic. Although several studies suggest that the spike protein of this virus interacts with the cell surface receptor, angi...
Dilara Akhter Supti, Farzana Akter, Md. Imranur Rahman, Md. Adnan Munim et al.
Obesity is a chronic condition which is identified by the buildup of excess body fat caused by a combination of various factors, including genetic predisposition and lifestyle choices. rs1137101 (A > G) polymorphism in the CHR1 domain of LEPR protein linked to different diseases including obesity. N...
Kumkum Kar, Md. Adnan Munim, Atqiya Fariha, Arpita Singha Roy et al.
Mahafujul Islam Quadery Tonmoy, Sk. Faisal Ahmed, Ithmam Hami, Shahriar Kabir Shakil et al.
Mucormycosis is a life-threatening fungal infection, particularly in immunocompromised patients. Mucormycosis has been reported to show resistance to available antifungal drugs and was recently found in COVID-19 as a co-morbidity that demands new classes of drugs. In an attempt to find novel inhibit...
Mahafujul Islam Quadery Tonmoy, Atqiya Fariha, Ithmam Hami, Kumkum Kar et al.
Aberrant expression of long non-coding RNAs (lncRNAs), caused by alterations in DNA methylation, is a driving factor in several cancers. Interplay between lncRNAs' aberrant methylation and expression in prostate cancer (PC) progression still remains largely elusive. Therefore, this study characteriz...
Md. Shahadat Hossain, Mahafujul Islam Quadery Tonmoy, Md. Nur Islam, Md. Sajedul Islam et al.
in CRC and CC. Retinoic acid and Estradiol were identified as putative therapeutic drugs for CRC and CC patients. This study will thus help in understanding the underlying molecular events in CRC and CC that may improve the detection of malignant lesions in primary screening and will broaden the cli...
Kumkum Kar, Atqiya Fariha, Md. Shahadat Hossain, Mahafujul Islam Quadery Tonmoy et al.
miRNAs are endogenous, non-coding and evolutionarily conserved RNA molecules. They have been found to be involved in the progression and proliferation of various cancers due to their contribution in post-transcriptional regulation. Stomach Adenocarcinoma (STAD) and Liver Hepatocellular Carcinoma (LI...
Md. Anayet Ullah, Priyanka Paul, Sadia Afrin Runa, Fatema Tuz Johura et al.
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is often associated with a poor prognosis, contributing significantly to cancer-related mortalities. It has been established that RAB10, a member of the RAS family, is overexpressed in HCC and plays an oncogenic role ...
Md. Shahadat Hossain, A. Q. M. Sala Uddin Pathan, Md. Nur Islam, Mahafujul Islam Quadery Tonmoy et al.
Abstract Genomic data analysis is a fundamental system for monitoring pathogen evolution and the outbreak of infectious diseases. Based on bioinformatics and deep learning, this study was designed to identify the genomic variability of SARS-CoV-2 worldwide and predict the impending mutation rate. An...
Arpita Singha Roy, Mahafujul Islam Quadery Tonmoy, Atqiya Fariha, Ithmam Hami et al.
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the novel coronavirus responsible for the ongoing pandemic of coronavirus disease (COVID-19). No sustainable treatment option is available so far to tackle such a public health threat. Therefore, designing a suitable vaccine to...
Arpita Singha Roy, Mahafujul Islam Quadery Tonmoy, Atqiya Fariha, Ithmam Hami et al.
Introduction: The ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has jeopardized our health system and leaving everyone in disarray. Despite the diligent cumulative effort of academia, there is hardly any light in...
Farzana Akter, I. K. M. Reaz Rahman, Dilara Akhter Supti, Md Abdul Kader et al.
Type 2 Diabetes Mellitus (T2DM) occurs due to a complex relationship of genetic, environmental, and physiological factors, encompassing insufficient pancreatic insulin synthesis, peripheral insulin resistance, and diverse molecular pathways. The transmembrane glycoprotein ectonucleotide pyrophosphat...
Syed Muktadir Al Sium, Mahafujul Islam Quadery Tonmoy, Sanjana Fatema Chowdhury, Fatema Tuz Zohra et al.
Abstract Background Long non-coding RNAs (lncRNAs) are crucial regulators in cancer, yet their epigenetic control in Lung Adenocarcinoma (LUAD) remains underexplored. Aim This study aimed to integrate multi-omics data to identify novel prognostic biomarkers and elucidate their potential mechanism. M...
Syed Muktadir Al Sium, Mahafujul Islam Quadery Tonmoy, Sanjana Fatema Chowdhury, Fatema Tuz Zohra et al.
Abstract Background Long non-coding RNAs (lncRNAs) are crucial regulators in cancer, yet their epigenetic control in Lung Adenocarcinoma (LUAD) remains underexplored. Aim This study aimed to integrate multi-omics data to identify novel prognostic biomarkers and elucidate their potential mechanism. M...
Sadia Afrin Runa, Mahafujul Islam Quadery Tonmoy, Md. Ashiqul Islam, Md. Aminul Islam
Cancer remains a leading cause of mortality worldwide, with genetic alterations such as single nucleotide polymorphisms (SNPs) playing a critical role in tumor progression and therapy resistance. Non-synonymous SNPs (nsSNPs) in AKT2, a key kinase in the PI3K/AKT signaling pathway, can impact protein...