Sajal Kumar Halder, Ive Sultana, Md Istiaq Mohhamad Shuvo, Aparna Shil et al.
SARS-CoV-2, a deadly coronavirus sparked COVID-19 pandemic around the globe. With an increased mutation rate, this infectious agent is highly transmissible inducing an escalated rate of infections and death everywhere. Hence, the discovery of a viable antiviral therapy option is urgent. Computationa...
Sajal Kumar Halder, Md. Oliullah Rafi, Esha Binte Shahriar, Sarah Albogami et al.
The cofilin-1 protein, encoded by CFL1, is an actin-binding protein that regulates F-actin depolymerization and nucleation activity through phosphorylation and dephosphorylation. CFL1 has been implicated in the development of neurodegenerative diseases (Alzheimer's disease and Huntington's disease),...
Zulkar Nain, Shital K. Barman, Md. Moinuddin Sheam, Shifath Bin Syed et al.
Despite the association of prevalent health conditions with coronavirus disease 2019 (COVID-19) severity, the disease-modifying biomolecules and their pathogenetic mechanisms remain unclear. This study aimed to understand the influences of COVID-19 on different comorbidities and vice versa through n...
Sajal Kumar Halder, Maria Mulla Mim, Md. Meharab Hassan Alif, Jannatul Fardous Shathi et al.
Determining novel therapeutic targets of Acinetobacter baumannii . Deleterious variants, causing antibiotic resistance, were identified by molecular docking and molecular dynamics simulation suggesting new therapeutic targets Oxa-376 and Oxa-530.
Aparna Shil, Most. Afrin Akter, Arafin Sultana, Sajal Kumar Halder et al.
Acinetobacter baumannii (A. baumannii) is an opportunistic bacterium that has developed multidrug resistance (MDR) to most of today’s antibiotics, posing a significant risk to human health. Considering the fact that developing novel drugs is a time-consuming and expensive procedure, this research fo...
Sajal Kumar Halder, Arafin Sultana, Mahbubul Kabir Himel, Aparna Shil
Monkeypox is a rapidly spreading transmissible disease induced by the monkeypox virus (MPXV), a major public health problem worldwide. The origin of monkeypox might be tracked to the continent of Africa, where it first afflicted primate species prior to spreading to the world. Severe health issues f...
Md Istiaq Mohhamad Shuvo, Sajal Kumar Halder, Nuhu Alam, Mahbubul Kabir Himel et al.
Abstract Staphylococcus aureus, a prevalent component of the human microbiota, is associated with skin infections to life-threatening diseases, presenting challenges in treatment options and necessitating the development of effective treatments. This study integrated computational and in vitro appro...
Sajal Kumar Halder, Ashish Ranjan Sharma, Tawsif Al Arian, Samantha Saha et al.
Background: The continuously emerging novel strains of SARS-CoV-2 remain a menace to the global population. The vicious delta variant (originated in India) is considered one of the most infectious/contagious variants of SARS-CoV-2. The transmission frequency of this variant is 225% higher than other...
Sajal Kumar Halder, Arafin Sultana, Iqrar Ahmad, Md. Oliullah Rafi et al.
Mycobacterium tuberculosis is a distinct gram-positive bacterium causing tuberculosis. For novel anti-tuberculosis drug discovery, virtual screening and machine learning was employed targeting dihydrofolate reductase in folate biosynthetic pathway.
Aparna Shil, Md Istiaq Mohhamad Shuvo, Habiba Sultana, Nuhu Alam et al.
This study explores the effects of Neem (Azadirachta indica) and Papaya (Carica papaya) leaf extracts on the pathogenicity of Staphylococcus aureus. Through in vitro assays, we investigated the impact of these medicinal plant extracts on bacterial metabolic activity and pathogenic factors. Results i...
Md. Nazmussakib Shuvo, Tawsif Al Arian, Farhan Fuad, Mahmood Hasan Noman et al.
Staphylococcus aureus, a bacterial pathogen, is increasingly linked to severe healthcare-associated diseases, from mild skin infections to toxic shock syndrome. Due to limitations in conventional methods, we use computational techniques to screen potential phytocompounds for new drug development and...
Md. Nipatul Hasan Nirob, Ive Sultana, Tawsif Al Arian, MD. Sazidul Islam et al.
Staphylococcus aureus, a gram-positive opportunistic pathogen, presents a growing global threat due to the rise of multidrug-resistant (MDR) strains. To counter this, we designed a multi-epitope vaccine (MEV) targeting the ClfA virulence protein using an integrative in silico approach. Sixty-one con...