Marjorie J Haskell, Kazi M. Jamil, Ferdaus Hassan, Janet M Peerson et al.
Background Recent evidence suggests that the vitamin A equivalency of beta-carotene from plant sources is lower than previously estimated. Objective We assessed the effect of 60 d of daily supplementation with 750 microg retinol equivalents (RE) of either cooked, puréed sweet potatoes; cooked, purée...
Shaikh Meshbahuddin Ahmad, Marjorie J Haskell, Rubhana Raqib, Charles B. Stephensen
Recommendations for vitamin A intake and liver stores are based on maintaining normal vision. We propose that higher levels may be required to maintain normal innate immune function. To test this hypothesis, we conducted an 8-wk residential study among 36 healthy Bangladeshi men with low vitamin A s...
Kazi Jamil, Kenneth H. Brown, Maleka Jamil, Janet M Peerson et al.
We assessed the effect of daily consumption of orange-fleshed sweet potatoes (OFSP), with or without added fat, on the vitamin A (VA) status of Bangladeshi women with low initial VA status. Women (n = 30/group) received one of the following for 6 d/wk over 10 wk: 1) 0 μg retinol activity equivalents...
Jennifer Lynn Ford, Joanne Balmer Green, Marjorie J Haskell, Shaikh Meshbahuddin Ahmad et al.
BACKGROUND: Model-based compartmental analysis has been used to describe and quantify whole-body vitamin A metabolism and estimate total body stores (TBS) in animals and humans. OBJECTIVES: We applied compartmental modeling and a super-child design to estimate retinol kinetic parameters and TBS for ...
Marjorie J Haskell, Ramendra Nath Mazumder, Janet M Peerson, A. Daniel Jones et al.
Background The deuterated-retinol-dilution (DRD) technique provides a quantitative estimate of total body stores of vitamin A. However, it is not known whether the technique can detect changes in vitamin A pool size in response to different intakes of vitamin A. Objective Our objective was to determ...
Marjorie J Haskell, Kazi Jamil, Janet M Peerson, Mohammed A Wahed et al.
The estimated average requirement (EAR) for vitamin A (VA) of adult males is based on the amount of dietary VA required to maintain adequate function and provide a modest liver VA reserve (0.07 μmol/g). In the present study, the paired-deuterated retinol dilution technique was used to estimate chang...
Shaikh Meshbahuddin Ahmad, Marjorie J Haskell, Rubhana Raqib, Charles B. Stephensen
Recommendations for vitamin A intake are based on maintaining liver stores of > or = 0.070 micromol/g, which is sufficient to maintain normal vision. We propose that higher levels may be required to maintain normal immune function. To test this hypothesis, we conducted an 8-week residential study am...
Francisco J. Rosales, Kitty K. Chau, Marjorie H. Haskell, Anuraj H. Shankar
The purpose of this study was to determine a cut-off value of the molar ratio of retinol-binding protein to transthyretin (RBP:TTR) to indicate marginal vitamin A (VA) deficiency. Plasma RBP and TTR were measured by radial immunodiffusion in two groups of patients, i.e., surgical patients with known...
Shaikh Meshbahuddin Ahmad, Marjorie J Haskell, Rubhana Raqib, Charles B. Stephensen
Current recommendations for vitamin A intake and liver stores (0.07 micromol/g) are based on maintaining normal vision. Higher levels may be required for maintaining normal immune function. The objective of this study was to assess the relationship between total body vitamin A stores in adult men an...
Tami Turner, Betty J. Burri, Marjorie J Haskell, Kazi Jamil et al.
Vitamin A (VA) is necessary for normal growth, development, immune function, and vision. Carotenoids such as β‐carotene (BC) and β‐cryptoxanthin (CX) can be converted to VA and are often the major source of VA in the diets of people from developing countries. Our clinical trial is assessing the impa...
Betty J. Burri, Marjorie J Haskell, Kazi M. Jamil, Maleka Jamil et al.
We are evaluating the effects of orange fleshed sweet potatoes and mandarin oranges on carotenoids and vitamin A (VA) of lactating Bangladeshi women with low VA status. The study is a randomized blind comparison of the interventions to positive and negative controls (retinyl palmitate and white‐fles...
Ana Beatriz Pérez-Expósito, Leslie R. Woodhouse, Marjorie J Haskell, Kazi M. Jamil et al.
Background Zinc and iron deficiencies have been associated with altered intestinal mucosal function. Objectives To examine the relationship between intestinal permeability and zinc and iron absorption in non‐pregnant, vitamin A‐depleted Bangladeshi women (plasma retinol < 1.05 umol/L). Methods Zi...
Marjorie J Haskell, Kazi M. Jamil, Narayan Kumar Das, Janet M Peerson et al.
The deuterated retinol dilution (DRD) technique provides a quantitative estimate of total body vitamin A (TBVA) pool size. The paired‐DRD technique permits calculation of the change (+ or −) in TBVA pool size that occurs in response to consumption of different amounts of vitamin A (mean change in po...
Ana Beatriz Pérez-Expósito, Bakhtiar Hossain, Leslie R. Woodhouse, Marjorie J Haskell et al.
The effect of vitamin A on zinc absorption in humans is unknown. We examined the independent effects of vitamin A or beta‐carotene intake and vitamin A status on zinc absorption in vitamin A‐depleted women (plasma retinol <1.05 mmol/L). Zinc absorption from meals with and without vitamin A added ...
Marjorie J Haskell, Kazi M. Jamil, Maleka Jamil, Janet M Peerson et al.
We assessed the effect of daily consumption of orange‐fleshed sweet potato (OFSP), with or without added fat, on the total body vitamin A (VA) pool size of Bangladeshi women with low initial VA status. Women (n=120) received for 60d either 1) 0 μg RAE/d as boiled white‐fleshed sweet potatoes (WFSP) ...