Lesley Bailie, Maurice B. Loughrey, Helen G. Coleman
Background & aims Certain subsets of colorectal serrated polyps (SP) have malignant potential. We performed a systematic review and meta-analysis to investigate the association between modifiable lifestyle factors and risk for SPs. Methods We conducted a systematic search of Medline, Embase, and We..
Shania M. Corry, Amy M.B. McCorry, Tamsin R.M. Lannagan, Niamh Leonard et al.
Objective Stroma-rich tumours represent a poor prognostic subtype in stage II/III colon cancer (CC), with high relapse rates and limited response to standard adjuvant chemotherapy. Design To address the lack of efficacious therapeutic options for patients with stroma-rich CC, we stratified our human...
Philip D. Dunne, Helen G. Coleman, Peter Bankhead, Matthew Alderdice et al.
Purpose: BRAF mutation occurs in 8-15% of colon cancers (CC), and is associated with poor prognosis in metastatic disease. Compared to wild-type BRAF (BRAFWT) disease, stage II/III CC patients with BRAF mutant (BRAFMT) tumors have shorter overall survival after relapse; however, time-to-relapse is n...