Pranoy Saha, Md. Rajdoula Rafe
Supramolecular chemistry introduces us to the macrocyclic host cyclodextrin, which has a hydrophobic cavity. The hydrophobic cavity has a higher affinity for hydrophobic guest molecules and forms host-guest complexation with non-covalent interaction. Three significant cyclodextrin kinds are α-cyclod...
Md. Sahab Uddin, Abdullah Al Mamun, Md. Asaduzzaman, Fakhrul Hosn et al.
BACKGROUND: Neurological disorders represent one of the most prominent causes of morbidity and mortality that adversely affect the lifestyle of patients and a major percentage of these diseases exists in developing countries. PURPOSE: The objective of this study was to examine the prevalence and pre...
Md. Rajdoula Rafe
Plants are used traditionally throughout the globe to treat various diseases. Traditionally used medicinal plants are an essential part of the health sector in Bangladesh due to its abundance of a vast source of ethno-medicine. Rural people from developing country like Bangladesh are greatly depende...
Md. Rajdoula Rafe, Pranoy Saha, Stephen Temitayo Bello
Glutamate activates the NMDARs, significantly affecting multiple processes such as learning, memory, synaptic integration, and excitatory transmission in the central nervous system. Uncontrolled activation of NMDARs is a significant contributor to synaptic dysfunction. Having a properly functioning ...
Abdur Rahman, Anamul Haque, Md. Sahab Uddin, Md. Mohsin Mian et al.
Background: Oxidative stress is strongly linked in the development of numerous chronic and degenerative disorders. Medicinal plants with antioxidant and anticholinesterase activities exert a key role for the management of oxidative stress related disorders mainly Alzheimer's disease (AD). Therefore ...
Md. Rajdoula Rafe
Neurodegenerative disorders encompass diseases that involve the degeneration of neurons, particularly those within the central nervous system. These are the most commonly observed disorders among the geriatric population. The treatment or management of this condition presents additional challenges d...
Rasna Jebin, Md. Islam Molla, Surid Mohammad Chowdhury, Md. Rajdoula Rafe
Grewia asiatica (Family-Malvaceae), known as Phalsa in Bangladesh, is also native to India, Nepal, Pakistan, Cambodia and Thailand. The plant has a long history of traditional uses. The present investigation was designed to evaluate acute toxicity test, antidepressant and sedative-hypnotic activitie...
Surid Mohammad Chowdhury, Md. Nuruzzaman Hossain, Md. Rajdoula Rafe
5-fluorouracil (5-FU) has been shown to have suffered from resistance which demands a solution entailing the development of 5-FU analogues. Our study aims to design a number of analogues of 5-FU and evaluate their effectiveness against thymidylate synthase (TS) in silico compared to parent 5-FU with...
Md. Rajdoula Rafe, Monira Ahsan, Choudhury Mahmood Hasan, Mohammad Mehedi Masud
Dendrophthoe falcata (Family Loranthaceae) is used extensively in rural area as a component of ethno-medicine for the treatment of various diseases. In this study, the crude extracts and the fractions obtained from D. falcata were investigated for potential chemical constituents and some biological ...
Md Sarwar Hossain, Mst Shirajum Munira, Md Rajdoula, Md. Monir Hossain et al.
Objective: To examine the analgesic and anti-inflammatory activities of Xanthosoma sagittifolium L. (X. sagittifolium) leaves. Methods: The fresh leaves of X. sagittifolium were extracted with methanol followed by fractionation using ethyl acetate fraction (EAF), n-hexane fraction, chloroform fracti...
Md. Siddiqul Islam, Ferdowsi Akter, Md. Mosiqur Rahman, Md. Rajdoula Rafe et al.
Purpose Cyclophosphamide, Epirubicin/Doxorubicin, 5-fluorouracil (CEF or CAF) chemotherapy has long been a standard first-line treatment for breast cancer. The genetic variations of enzymes that are responsible for the metabolism of these drugs have been linked to altered treatment response and toxi...
Sabarni Sarker, Md. Rajdoula Rafe
BACKGROUND: The therapeutic use of nifedipine, a dihydropyridine calcium channel blocker, is limited due to its poor solubility profile, rapid onset of its action, stability profile and short biological half-life. Many formulation techniques have been applied to improve physicochemical and pharmacol...
Ananta Sutra Dhar, Mahbubur Rahman, Md. Rajdoula Rafe, Md. Islam Molla
Abstract In this study, methanolic crude extracts of Stephania japonica (Thunb.) Miers. (MESJ) whole plants were examined for possible antidepressant and sedative-hypnotic activities. Herein, the forced swimming test and tail suspension test were conducted to explore the antidepressant activity. In ...
Md. Rajdoula Rafe, Syeda Naureen Ahmed, Zebunnesa Ahmed
Abstract Chikungunya virus is an Alphavirus that possesses characteristics similar to that of an arthropod-borne virus. Chikungunya virus has been one of the major concerns for the last few decades due to its nature of explosive spreading throughout the world. This article is intended to give detail...
Nadia Hia Sraboni, Md. Rajdoula Rafe, Mohammad Musarraf Hussain
Natural compounds have long been employed as medicines throughout the course of human history. Traditional medicine has employed and still uses natural materials, especially plant treatments, based on practical observations rather than pharmaceutical research. Ixora chinensis (Lam) plant has several...