Md. Abdullah‐Al‐Kamran Khan, Md. Rabi Us Sany, Md. Shafiqul Islam, Abul Bashar Mir Md. Khademul Islam
Detailed molecular mechanism of SARS-CoV-2 pathogenesis is still elusive to address its deadlier nature and to design effective theraputics. Here, we present our study elucidating the interplay between the SARS-CoV and SARS-CoV-2 viruses’; and host’s miRNAs, an epigenetic regulator, as a mode of pat...
Abul Bashar Mir Md. Khademul Islam, Md. Abdullah‐Al‐Kamran Khan
An incomplete understanding of the molecular mechanisms behind impairment of lung pathobiology by COVID-19 complicates its clinical management. In this study, we analyzed the gene expression pattern of cells obtained from biopsies of COVID-19-affected patient and compared to the effects observed in ...
Abul Bashar Mir Md. Khademul Islam, Md. Abdullah‐Al‐Kamran Khan, Rasel Ahmed, Md. Sabbir Hossain et al.
Abstract Background Although it is becoming evident that individual’s immune system has a decisive influence on SARS-CoV-2 disease progression, pathogenesis is largely unknown. In this study, we aimed to profile the host transcriptome of COVID-19 patients from nasopharyngeal samples along with virus...
Rafeed Rahman Turjya, Md. Abdullah‐Al‐Kamran Khan, Abul Bashar Mir Md. Khademul Islam
BACKGROUND: Regulatory roles of long noncoding RNAs (lncRNAs) during viral infection has become more evident in last decade, but are yet to be explored for SARS-CoV-2. MATERIALS & METHODS: We analyzed RNA-seq dataset of SARS-CoV-2 infected lung epithelial cells to identify differentially expressed g...
Md. Abdullah‐Al‐Kamran Khan, Abul Bashar Mir Md. Khademul Islam
The constant rise of the death toll and cases of COVID-19 has made this pandemic a serious threat to human civilization. Understanding of host-SARS-CoV-2 interaction in viral pathogenesis is still in its infancy. In this study, we utilized a blend of computational and knowledgebase approaches to mod...
Shawon Ahmmed, Md. Abdullah‐Al‐Kamran Khan, Md. Mostavi Enan Eshik, Nusrat Jahan Punom et al.
BACKGROUND: Due to its rapid lethal effect in the early development stage of shrimp, acute hepatopancreatic necrosis disease (AHPND) has been causing great economic losses, since its first outbreak in southeast China in 2009. Vibrio parahaemolyticus, carrying the pirA and pirB toxin genes is known t...
Md. Abdullah‐Al‐Kamran Khan, Md. Rabi Us Sany, Md. Shafiqul Islam, Md. Saheb Mehebub et al.
Abstract Detailed molecular mechanism of SARS-CoV-2 pathogenesis is still elusive to address its deadlier nature and to design effective theraputics. Here, we present our study elucidating the interplay between the SARS-CoV and SARS-CoV-2 viruses’; and host’s miRNAs, an epigenetic regulator, as a mo...
Md. Sajedul Islam, Md. Abdullah‐Al‐Kamran Khan, Md. Wahid Murad, Marwah Karim et al.
BACKGROUND: The concurrent Zika Virus (ZIKV) outbreaks in the United States and Northeast Brazil have evoked global surveillance. Zika infection has been correlated with severe clinical symptoms, such as microcephaly, Guillain-Barré syndrome, and other congenital brain abnormalities. Recent data sug...
Shahana Sharmin, Bristy Sabikunnahar, Arpita Aditya, Md. Abdullah‐Al‐Kamran Khan et al.
Objective: Human papillomavirus (HPV) comprises around 120 genotypically related viruses, classified into low- and high-risk HPVs, which are capable of replicating inside the keratinocytes of skin or mucous membranes. Studies suggest that infections with HPV-16 or HPV-18 have a higher rate of develo...
Abul Bashar Mir Md. Khademul Islam, Eusra Mohammad, Md. Abdullah‐Al‐Kamran Khan
BACKGROUND: MicroRNAs are ~ 22-nucleotide-long biological modifiers that act as the post-transcriptional modulator of gene expression. Some of them are identified to be embedded within the introns of protein-coding genes, these miRNAs are called the intronic miRNAs. Previous findings state that thes...
Riyad Hossen, Myles Courtney, ATR Sim, Md. Abdullah‐Al‐Kamran Khan et al.
Premise: Seaweeds are gaining substantial research interest, particularly for genomic applications, where high-quality DNA is a prerequisite. Extracting DNA from these organisms presents challenges due to high levels of biomacromolecules resulting from their diverse cell structures. Existing protoco...
Md. Abdullah‐Al‐Kamran Khan, Abul Bashar Mir Md. Khademul Islam
Abstract The constant rise of the death toll and cases of COVID-19 has made this pandemic a serious threat to human civilization. Understanding of host-SARS-CoV-2 interaction in viral pathogenesis is still in its infancy. In this study we aimed to correlate how SARS-CoV-2 utilizes its proteins for t...
Md. Sajedul Islam, Md. Abdullah‐Al‐Kamran Khan
Chikungunya virus (CHIKV) that causes chikungunya fever, is an alphavirus that belongs to the Togaviridae family containing a single-stranded RNA genome. Mosquitoes of the Aedes species act as the vectors for this virus and can be found in the blood, which can be passed from an infected person to a ...
Shahana Sharmin, Fatima Tuj Zohura, Md. Sajedul Islam, Anika Shimonty et al.
BACKGROUND: Cervical cancer is a gynecologic cancer type that develops in the cervix, accounting for 8% mortality of all female cancer patients. Infection with specific human papillomavirus (HPV) types is considered the most severe risk factor for cervical cancer. In the context of our socioeconomic...
Md. Abdullah‐Al‐Kamran Khan, Rafeed Rahman Turjya, Abul Bashar Mir Md. Khademul Islam
Amongst the anti-TNF-α therapy for rheumatoid arthritis and other autoimmune diseases, Adalimumab mAb is one of the best candidates. However, several risk factors are found to be associated with higher doses. Improvement of the binding properties will therefore significantly increase its therapeutic...