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Results for “"Michael W. Konstan"”

16+ results

Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del<i>CFTR</i>

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Claire Wainwright, J.S. Elborn, Bonnie W. Ramsey, Gautham Marigowda et al.

Journal: New England Journal of MedicineYear: 2015Citations: 1618

BACKGROUND: Combination treatment with the cystic fibrosis transmembrane conductance regulator (CFTR) modulators tezacaftor (VX-661) and ivacaftor (VX-770) was designed to target the underlying cause of disease in patients with cystic fibrosis. METHODS: through week 24 (calculated as a percentage) ..

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Health SciencesMedicinePulmonary and Respiratory MedicineOpen Access
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Phase II studies of nebulised Arikace in CF patients with<i>Pseudomonas aeruginosa</i>infection

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John P. Clancy, Lieven Dupont, Michael W. Konstan, Joanne Billings et al.

Journal: ThoraxYear: 2013Citations: 219

RATIONALE: Arikace is a liposomal amikacin preparation for aerosol delivery with potent Pseudomonas aeruginosa killing and prolonged lung deposition. OBJECTIVES: To examine the safety and efficacy of 28 days of once-daily Arikace in cystic fibrosis (CF) patients chronically infected with P aeruginos...

Health SciencesMedicinePulmonary and Respiratory MedicineOpen Access
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Results of the COVID-19 mental health international for the general population (COMET-G) study

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Konstantinos Ν. Fountoulakis, Grigorios N. Karakatsoulis, Seri Abraham, Kristina Adorjan et al.

Journal: European NeuropsychopharmacologyYear: 2021Citations: 138

Introduction There are few published empirical data on the effects of COVID‐19 on mental health, and until now, there is no large international study. Material and methods During the COVID-19 pandemic, an online questionnaire gathered data from 55,589 participants from 40 countries (64.85% females a...

Social SciencesPsychologyClinical PsychologyOpen Access
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The Importance and Benefits of Species

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Claude Gascon, Thomas M. Brooks, Topiltzin Contreras‐MacBeath, Nicolas Heard et al.

Journal: Current BiologyYear: 2015Citations: 117

Humans depend on biodiversity in myriad ways, yet species are being rapidly lost due to human activities. The ecosystem services approach to conservation tries to establish the value that society derives from the natural world such that the true cost of proposed development actions becomes apparent ...

Physical SciencesEnvironmental ScienceEcologyOpen Access
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Conservation resource allocation, small population resiliency, and the fallacy of conservation triage

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David A. Wiedenfeld, Allison C. Alberts, Ariadne Angulo, Elizabeth L. Bennett et al.

Journal: Conservation BiologyYear: 2021Citations: 72

Some conservation prioritization methods are based on the assumption that conservation needs overwhelm current resources and not all species can be conserved; therefore, a conservation triage scheme (i.e., when the system is overwhelmed, species should be divided into three groups based on likelihoo...

Physical SciencesEnvironmental ScienceEcological ModelingOpen Access
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The global case fatality rate of coronavirus disease 2019 by continents and national income: A meta‐analysis

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Ramy Abou Ghayda, Keum Hwa Lee, Young Joo Han, Seohyun Ryu et al.

Journal: Journal of Medical VirologyYear: 2022Citations: 60

The aim of this study is to provide a more accurate representation of COVID-19's case fatality rate (CFR) by performing meta-analyses by continents and income, and by comparing the result with pooled estimates. We used multiple worldwide data sources on COVID-19 for every country reporting COVID-19 ...

Physical SciencesMathematicsModeling and SimulationOpen Access
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The effect of different degrees of lockdown and self-identified gender on anxiety, depression and suicidality during the COVID-19 pandemic: Data from the international COMET-G study.

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Konstantinos Ν. Fountoulakis, Grigorios N. Karakatsoulis, Seri Abraham, Kristina Adorjan et al.

Journal: Psychiatry ResearchYear: 2022Citations: 34

Introduction During the COVID-19 pandemic various degrees of lockdown were applied by countries around the world. It is considered that such measures have an adverse effect on mental health but the relationship of measure intensity with the mental health effect has not been thoroughly studied. Here ...

Social SciencesPsychologyClinical PsychologyOpen Access
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Brown Bear (<i>Ursus arctos</i>; Eurasia)

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Jon E. Swenson, Hüseyin Ambarlı, Jon M. Arnemo, Leonid Baskin et al.

Journal: Cambridge University Press eBooksYear: 2020Citations: 19

This chapter comprises the following sections: names, taxonomy, subspecies and distribution, descriptive notes, habitat, movements and home range, activity patterns, feeding ecology, reproduction and growth, behavior, parasites and diseases, status in the wild, and status in captivity.

Physical SciencesEnvironmental ScienceEcologyOpen Access
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Validation of the Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) questionnaire for adults

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Marco Solmi, Trevor Thompson, Andrés Estradé, Agorastos Agorastos et al.

Journal: Journal of Affective DisordersYear: 2022Citations: 18

Background The Collaborative Outcome study on Health and Functioning during Infection Times (COH-FIT; www.coh-fit.com) is an anonymous and global online survey measuring health and functioning during the COVID-19 pandemic. The aim of this study was to test concurrently the validity of COH-FIT items ...

Social SciencesPsychologyClinical PsychologyOpen Access
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Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study

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Marco Solmi, Trevor Thompson, Andrés Estradé, Agorastos Agorastos et al.

Journal: Psychiatry ResearchYear: 2024Citations: 17

, penalized cubic splines, linear regression, correlation analyses were conducted. Analyzing 121,066/142,364 initiated surveys, WHO-5/P-score worsened intra-pandemic by 11.1±21.1/13.2±17.9 points (effect size d=0.50/0.60) (comparable results in representative/weighted non-probability samples). Perso...

Social SciencesPsychologyClinical PsychologyOpen Access
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Image‐based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno‐oncology Biomarker Working Group on Breast Cancer

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Chowdhury Arif Jahangir, David B. Page, Glenn Broeckx, Claudia Aura Gonzalez et al.

Journal: The Journal of PathologyYear: 2024Citations: 16

Recent advances in the field of immuno-oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and treatment response in various cancers. Multiplex immunohistochemistry and immun...

Health SciencesMedicineOncologyOpen Access
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Somatic multicomorbidity and disability in patients with psychiatric disorders in comparison to the general population: a quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study)

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Konstantinos Ν. Fountoulakis, Grigorios N. Karakatsoulis, Seri Abraham, Kristina Adorjan et al.

Journal: CNS SpectrumsYear: 2024Citations: 12

Abstract Background The prevalence of medical illnesses is high among patients with psychiatric disorders. The current study aimed to investigate multi-comorbidity in patients with psychiatric disorders in comparison to the general population. Secondary aims were to investigate factors associated wi...

Health SciencesMedicineEpidemiologyOpen Access
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Collaborative outcomes study on health and functioning during infection times (COH-FIT): Insights on modifiable and non-modifiable risk and protective factors for wellbeing and mental health during the COVID-19 pandemic from multivariable and network analyses

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Marco Solmi, Trevor Thompson, Samuele Cortese, Andrés Estradé et al.

Journal: European NeuropsychopharmacologyYear: 2024Citations: 11

There is no multi-country/multi-language study testing a-priori multivariable associations between non-modifiable/modifiable factors and validated wellbeing/multidimensional mental health outcomes before/during the COVID-19 pandemic. Moreover, studies during COVID-19 pandemic generally do not report...

Social SciencesPsychologyExperimental and Cognitive PsychologyOpen Access
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Collaborative Outcomes Study on Health and Functioning During Infection Times (COH-FIT): Global and Risk-Group Stratified Course of Well-Being and Mental Health During the COVID-19 Pandemic in Adolescents

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Marco Solmi, Trevor Thompson, Samuele Cortese, Andrés Estradé et al.

Journal: Journal of the American Academy of Child & Adolescent PsychiatryYear: 2024Citations: 8

OBJECTIVE: To identify the COVID-19 pandemic impact on well-being/mental health, coping strategies, and risk factors in adolescents worldwide. METHOD: , penalized cubic splines, linear regression, and correlation analyses were conducted. RESULTS: Analyzing 8,115 of 8,762 initiated surveys (represent...

Social SciencesPsychologyClinical PsychologyOpen Access
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A systematic review and meta-analysis of bovine tuberculosis occurrence and burden in Bangladesh, 1970–2023

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Sk Shaheenur Islam, Konstantinos Pateras, S. M. Lutful Kabir, Polychronis Kostoulas et al.

Journal: Epidemiology and InfectionYear: 2024Citations: 4

We aimed to estimate the overall apparent prevalence, true prevalence, and the spatial, temporal, and test-specific burden of bovine tuberculosis in Bangladesh. PubMed, Web of Science, Scopus, Google Scholar, and BanglaJOL were searched for bovine tuberculosis publications in Bangladesh from 1 Janua...

Health SciencesMedicineInfectious DiseasesOpen Access
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