Md Ashraful Alam, Nusrat Subhan, Mahbubur Rahman, Shaikh Jamal Uddin et al.
Flavonoids are important natural compounds with diverse biologic activities. Citrus flavonoids constitute an important series of flavonoids. Naringin and its aglycone naringenin belong to this series of flavonoids and were found to display strong anti-inflammatory and antioxidant activities. Several...
Md Ashraful Alam, Nusrat Subhan, Hemayet Hossain, Murad Hossain et al.
Hydroxycinnamic acid derivatives are important class of polyphenolic compounds originated from the Mavolanate-Shikimate biosynthesis pathways in plants. Several simple phenolic compounds such as cinnamic acid, p-coumaric acid, ferulic acid, caffeic acid, chlorgenic acid, and rosmarinic acid belong t...
Shoumen Lasker, Md Mizanur Rahman, Faisal Parvez, Mushfera Zamila et al.
The main objective of this experiment was to determine the effects of yogurt supplementation on fat deposition, oxidative stress, inflammation and fibrosis in the liver of rats with high-fat (HF) diet-induced obesity. Male Wistar rats were used in this study and were separated into the following fou...
Md Ashraful Alam, Riaz Uddin, Nusrat Subhan, Mahbubur Rahman et al.
Diabetes, obesity, and metabolic syndrome are becoming epidemic both in developed and developing countries in recent years. Complementary and alternative medicines have been used since ancient era for the treatment of diabetes and cardiovascular diseases. Bitter melon is widely used as vegetables in...
Anayt Ulla, Md Ashraful Alam, Biswajit Sikder, Farzana Akter Sumi et al.
BACKGROUND: Obesity and related complications have now became epidemic both in developed and developing countries. Cafeteria type diet mainly composed of high fat high carbohydrate components which plays a significant role in the development of obesity and metabolic syndrome. This study investigated...
Raquibul Hasan, Shoumen Lasker, Ahasanul Hasan, Farzana Zerin et al.
The antidiabetic drug canagliflozin is reported to possess several cardioprotective effects. However, no studies have investigated protective effects of canagliflozin in isoprenaline (ISO)-induced cardiac oxidative damage-a model mimicking sympathetic nervous system (SNS) overstimulation-evoked card...
Raquibul Hasan, Shoumen Lasker, Ahasanul Hasan, Farzana Zerin et al.
Diabetes is a leading cause of chronic kidney disease, and the high prevalence of sympathetic nervous system (SNS) hyperactivity in diabetic patients makes them further susceptible to SNS-mediated oxidative stress and accelerated kidney damage. Here, we investigated if canagliflozin can reverse isop...
Md Mizanur Rahman, Mohammad Nazmul Alam, Anayt Ulla, Farzana Akther Sumi et al.
BACKGROUND: Cardamom is a well-known spice in Indian subcontinent, used in culinary and traditional medicine practices since ancient times. The current investigation was untaken to evaluate the potential benefit of cardamom powder supplementation in high carbohydrate high fat (HCHF) diet induced obe...
Md Ashraful Alam, Priota Islam, Nusrat Subhan, Md Mizanur Rahman et al.
Mohammad Nazmul Alam, Murad Hossain, Md Mizanur Rahman, Nusrat Subhan et al.
The objective of this study was to investigate the effect of astaxanthin on isoproterenol (ISO)-induced myocardial infarction and cardiac hypertrophy in rats. To evaluate the effect of astaxanthin on ISO-induced cardiac dysfunction, 18 aged Long Evans male rats were evenly divided into three groups....
Riaz Uddin, Moni Rani Saha, Nusrat Subhan, Hemayet Hossain et al.
PURPOSE: Gardenia jasminoides is a traditional medicinal plant rich in anti-inflammatory flavonoids and phenolic compounds and used for the treatment of inflammatory diseases and pain. In this present study, antioxidant potential of Gardenia jasminoides leaves extract was evaluated by using various ...
Nusrat Subhan, Md Ashraful Alam, Firoj Ahmed, Israt Jahan Shahid et al.
The results of neuropharmacological, microbiological and toxicological studies on the ethanol extract of the bark of Excoecaria agallocha are reported. The extract (100 and 200 mg/kg dosages) was found to produce a profound decrease in exploratory activity in a dose-dependent manner. It also showed ...
Md Mizanur Rahman, Awale Yousuf Muse, Mohammad Zubair Khan, Ismaile Hussein Ahmed et al.
Background Liver fibrosis is a leading pathway to cirrhosis and a global clinical issue. Oxidative stress mediated tissue damage is one of the prime causes of hepatic dysfunction and fibrosis. Apocynin is one of many strong antioxidants. Objective To evaluate the effect of apocynin in the CCl 4 admi...
Farzana Akther Sumi, Biswajit Sikder, Md Mizanur Rahman, Shamshad Rahman Lubna et al.
We evaluated the cardioprotective effect of Aloe vera gel isoprenaline (ISO)-administered myocardial infarction in rats. ISO administration increased lipid peroxidation and oxidative stress in rats, which were ameliorated by A. vera gel supplementation. Our study also revealed that creatine kinase-M...
Md Ashraful Alam, Nusrat Subhan, M. A. Awal, M. S. Alam et al.
The ethanol extract of Ruellia tuberosa L. (Acanthaceae) was evaluated for its antinociceptive and anti-inflammatory properties in experimental mice and/or rat models. In the hot-plate test, the group that received a dose of 300 mg/kg showed maximum time needed for the response against thermal stimu...